KR860002049B1 - 플루오로-프로스타사이클린의 제조방법 - Google Patents

플루오로-프로스타사이클린의 제조방법 Download PDF

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Publication number
KR860002049B1
KR860002049B1 KR8201052A KR820001052A KR860002049B1 KR 860002049 B1 KR860002049 B1 KR 860002049B1 KR 8201052 A KR8201052 A KR 8201052A KR 820001052 A KR820001052 A KR 820001052A KR 860002049 B1 KR860002049 B1 KR 860002049B1
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KR
South Korea
Prior art keywords
fluoro
compound
formula
epoxy
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8201052A
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English (en)
Korean (ko)
Other versions
KR830009079A (ko
Inventor
윌리암 홀란드 조지
마아크 한스
로젠 페리
Original Assignee
쿠르트 네셀보쉬, 한스 스튀클린
에프 · 호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쿠르트 네셀보쉬, 한스 스튀클린, 에프 · 호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트 filed Critical 쿠르트 네셀보쉬, 한스 스튀클린
Publication of KR830009079A publication Critical patent/KR830009079A/ko
Application granted granted Critical
Publication of KR860002049B1 publication Critical patent/KR860002049B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
KR8201052A 1981-03-11 1982-03-11 플루오로-프로스타사이클린의 제조방법 Expired KR860002049B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24281881A 1981-03-11 1981-03-11
US242818 1981-03-11
US242,818 1981-03-11

Publications (2)

Publication Number Publication Date
KR830009079A KR830009079A (ko) 1983-12-17
KR860002049B1 true KR860002049B1 (ko) 1986-11-20

Family

ID=22916307

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8201052A Expired KR860002049B1 (ko) 1981-03-11 1982-03-11 플루오로-프로스타사이클린의 제조방법

Country Status (5)

Country Link
JP (1) JPS57171988A (enExample)
KR (1) KR860002049B1 (enExample)
BE (1) BE892434A (enExample)
GR (1) GR76075B (enExample)
ZA (1) ZA821449B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57165382A (en) * 1981-04-06 1982-10-12 Teijin Ltd Fluoro-pgi2 compound and its preparation
EP0054795B1 (en) * 1980-12-09 1987-07-15 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof
JPS57200378A (en) * 1981-06-02 1982-12-08 Teijin Ltd Halogenated pgi2 and its preparation
JPS58150583A (ja) * 1982-03-04 1983-09-07 Teijin Ltd 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物
JPS59227888A (ja) * 1983-06-10 1984-12-21 Asahi Glass Co Ltd ７−フルオロプロスタグランジン類の製造方法
DE69531110T2 (de) * 1994-02-17 2004-05-19 Asahi Glass Co., Ltd. Difluoroprostacycline, Zwischenprodukte zu deren Herstellung und Herstellungsverfahren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU184917B (en) * 1980-10-27 1984-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 7-substituted pgi down 2 derivatives
JPS57165382A (en) * 1981-04-06 1982-10-12 Teijin Ltd Fluoro-pgi2 compound and its preparation

Also Published As

Publication number Publication date
BE892434A (fr) 1982-09-10
GR76075B (enExample) 1984-08-03
JPS57171988A (en) 1982-10-22
ZA821449B (en) 1983-01-26
KR830009079A (ko) 1983-12-17

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