KR860001121A - 신규 프리마이신 염의 제조방법 - Google Patents

신규 프리마이신 염의 제조방법 Download PDF

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Publication number
KR860001121A
KR860001121A KR1019850004769A KR850004769A KR860001121A KR 860001121 A KR860001121 A KR 860001121A KR 1019850004769 A KR1019850004769 A KR 1019850004769A KR 850004769 A KR850004769 A KR 850004769A KR 860001121 A KR860001121 A KR 860001121A
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KR
South Korea
Prior art keywords
barium
salt
acid
primycin
aliphatic
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KR1019850004769A
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English (en)
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KR880001236B1 (ko
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데카니(외 1) 기울라
Original Assignee
기울라 스주크, 타마스 스주츠
치노인 교기스져 에스 베게스제티 테르메케크 기야라르트
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Publication of KR860001121A publication Critical patent/KR860001121A/ko
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Publication of KR880001236B1 publication Critical patent/KR880001236B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/238—Cyclohexane rings substituted by two guanidine radicals, e.g. streptomycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

신규 프리마이신 염의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 프리마이신 설페이트를 탄소수 1-4를 함유하는 지방족 알콜로 처리하여 얻어진 현탁액을 바리움 염과 반응시켜서 신규 프리마이신 염을 제조하는 방법.
  2. 제1항에서, 바리움염으로서 유기산 또는 무기산과 바리움으로 부터 형성된 바림움염을 사용하는 방법.
  3. 제1항 및 2항에서, 유기산으로 C1-16지방족카본산, 할로겐화 지방족카본산, 지방족디카본산, 방향족카본산, 치환방향족 카본산 또는 유기설폰산을 사용하고 무기산으로 할로겐화 수소를 사용하는 방법.
  4. 제1항 내지 3항에서, 반응 공정중에서 바리움염을 제조하는 방법.
  5. 제1항 내지 4항에서, 바리움 카보네이트를 상응하는 유기 또는 무기산에 용해하든가 또는 바리움카보네이트 C1-4지방족 알콜로 처리한 용액을 상응하는 유기 또는 무기산에 용해하고 이렇게 얻어진 용액을 증발시킨 잔류물을 C1-4지방족알콜 또는 에테르에 용해시켜서 바를움염을 제조하는 방법.
  6. 제1-5항에서, 바리움 하이드록사이드의 포화 수용액을 지방족 알콜 및/또는 물과 형성된 상응하는 유기 또는 무기산 용액과 반응시키고 반응혼합물을 여과하여 바림움염을 제조하는 방법.
  7. 제1-6항에서, 프리마이신 설페이트와 바리움염과 반응을 20-80℃의 온도 바람직하게는 용매의 비점 온도에서 행하는 방법.
  8. 제1-7항에서, 생성된 프리마이신염을 분리하는 방법.
  9. 제8항에서, 바리움 설페이트를 여과하고 여액을 진공 증류한 후 잔류물을 용매-바람직하게는 아세톤과 물의 2:1혼합물 및/또는 에테트로 처리하여 프리마이신 염을 분리하는 방법.
  10. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850004769A 1984-07-03 1985-07-03 프리마이신 염의 제조방법 KR880001236B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU842571A HU196822B (en) 1984-07-03 1984-07-03 Process for producing primicin salts
HU2571/84 1984-07-03

Publications (2)

Publication Number Publication Date
KR860001121A true KR860001121A (ko) 1986-02-22
KR880001236B1 KR880001236B1 (ko) 1988-07-12

Family

ID=10960054

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850004769A KR880001236B1 (ko) 1984-07-03 1985-07-03 프리마이신 염의 제조방법

Country Status (11)

Country Link
US (2) US4782141A (ko)
EP (1) EP0167146B1 (ko)
JP (1) JPS6163695A (ko)
KR (1) KR880001236B1 (ko)
AT (1) ATE57705T1 (ko)
CA (1) CA1257254A (ko)
DE (1) DE3580200D1 (ko)
DK (1) DK301485A (ko)
FI (1) FI79544C (ko)
HU (1) HU196822B (ko)
IL (1) IL75643A0 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU202248B (en) * 1988-06-14 1991-02-28 Chinoin Gyogyszer Es Vegyeszet Process for producing pseudo-primicin, it's components and pharmaceutical compositions containing them as active components
US5260426A (en) * 1988-06-14 1993-11-09 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. Process for the preparation of pseudo primycin
US5217707A (en) * 1988-06-16 1993-06-08 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Pharmaceutical composition and process for the preparation thereof
US5244880A (en) * 1988-11-02 1993-09-14 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Stable aqueous solutions of prymicin and pharmaceutical and cosmetic compositions containing these solutions
HU205366B (en) * 1988-11-18 1992-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing water-soluble primycin complexes and pharmaceutical compositions comprising such active ingredient
HUP9600847A3 (en) * 1996-04-02 1999-08-30 Human Oltoanyagtermeloe Es Gyo Nonstochiometric compds. of primycins with ciclodextrin derivatives, pharmaceutical compns. contg. the said compds. and process for preparing them
HU230455B1 (hu) 2011-10-25 2016-07-28 Pannonpharma Gyógyszergyártó Zrt. Primycin vagy primycin komponensek vagy ezek kombinációi mint speciális kórokozócsoportok által okozott fertőzések kezelésére vagy megelőzésére alkalmas gyógyszerhatóanyagok

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2518135A (en) * 1946-11-01 1950-08-08 Univ Ohio State Res Found Uniformly 2-substituted glucopyranose polymers
US2609368A (en) * 1950-10-21 1952-09-02 Univ Ohio State Res Found Carbohydrate processes
US3244590A (en) * 1960-12-23 1966-04-05 Rutgers Res And Educational Fo Polyenic compounds and procedures related thereto
DE1617383C3 (de) * 1965-10-20 1975-05-15 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt, Budapest Verfahren zur Herstellung von Primycin
BE756856A (fr) * 1969-09-30 1971-03-01 Chinoin Gyogyszer Es Vegyeszet Compositions antibiotiques nouvelles possedant un effet therapeutique accru et leur preparation
US4035568A (en) * 1971-06-07 1977-07-12 Rutgers Research And Educational Foundation Derivatives of polyene macrolide antibiotics
PL122884B1 (en) * 1978-07-19 1982-08-31 Politechnika Gdanska Method of manufacture of quaternary trimethylammonium salts of inorganic derivatives of polyene macrolides
US4404189A (en) * 1981-01-21 1983-09-13 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Synergistic antimicrobial compositions

Also Published As

Publication number Publication date
FI852508L (fi) 1986-01-04
JPS6163695A (ja) 1986-04-01
HU196822B (en) 1989-01-30
KR880001236B1 (ko) 1988-07-12
EP0167146A3 (en) 1986-11-05
FI79544C (fi) 1990-01-10
FI852508A0 (fi) 1985-06-25
US4782141A (en) 1988-11-01
DK301485A (da) 1987-01-03
FI79544B (fi) 1989-09-29
HUT40808A (en) 1987-02-27
DK301485D0 (da) 1985-07-02
DE3580200D1 (de) 1990-11-29
EP0167146B1 (de) 1990-10-24
ATE57705T1 (de) 1990-11-15
US5023242A (en) 1991-06-11
IL75643A0 (en) 1985-10-31
EP0167146A2 (de) 1986-01-08
CA1257254A (en) 1989-07-11

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