KR860000241A - 살리싸이클산의 (-)캄포렌산 에스테르의 제조방법 - Google Patents
살리싸이클산의 (-)캄포렌산 에스테르의 제조방법 Download PDFInfo
- Publication number
- KR860000241A KR860000241A KR1019850004510A KR850004510A KR860000241A KR 860000241 A KR860000241 A KR 860000241A KR 1019850004510 A KR1019850004510 A KR 1019850004510A KR 850004510 A KR850004510 A KR 850004510A KR 860000241 A KR860000241 A KR 860000241A
- Authority
- KR
- South Korea
- Prior art keywords
- preparing
- camphoric
- acid
- tetrahydrofuran
- salicylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 상온에서 유기산수용염의 존재하에 유기중성 용매내에서 행해지는 살리싸이클산을 가진(-)캄포렌산 클로라이드의 축합을 특징으로 하는 다음 일반식을 가진 살리싸이클산의(-)캄포렌산 에스테르의 제조공정.
- 제1항에 있어서, 피리딘의 존재하 10-20℃에서 테트라하이드로퓨란내에서 행해지는 축합 반응을 특징으로 하는 공정.
- 제2항에 있어서, 테트라하이드로퓨란 대신에 디옥산이 사용되는 것을 특징으로 하는 공정.
- 제2항에 있어서, 테트라하이드로퓨란 대신에 무수 메틸렌 클로라이드(에탄올로 부터 유리된)가 사용되는 것을 특징으로 하는 공정.※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21608/84A IT1176321B (it) | 1984-06-26 | 1984-06-26 | Estere dell'acido salicilico avente attivita' mucosecretolitica,antinfiammatoria,analgesica,antipiretica adatto a dare sali farmaceuticamente accettabili; procedimento per la preparazione,e composizioni farmaceutiche contenenti l'estere o i suoi sali |
| IT21608A/84 | 1984-06-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR860000241A true KR860000241A (ko) | 1986-01-27 |
| KR920004457B1 KR920004457B1 (ko) | 1992-06-05 |
Family
ID=11184267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850004510A KR920004457B1 (ko) | 1984-06-26 | 1985-06-25 | 살리실산의 (-)캄포렌산 에스테르의 제조방법 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4631293A (ko) |
| EP (1) | EP0166918B1 (ko) |
| JP (1) | JPS6133143A (ko) |
| KR (1) | KR920004457B1 (ko) |
| AT (1) | ATE44463T1 (ko) |
| DE (1) | DE3571394D1 (ko) |
| IT (1) | IT1176321B (ko) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2561193A (en) * | 1949-05-20 | 1951-07-17 | Dow Chemical Co | alpha-methyl benzyl esters of campholic and fencholic acids |
| US2835697A (en) * | 1956-05-10 | 1958-05-20 | Upjohn Co | Salicylic acid beta-cyclopentylopropionate |
| DE1543416A1 (de) * | 1965-04-01 | 1969-09-11 | Parke Davis & Co | Verfahren zur Herstellung von halogenhaltigen 2-Acyloxybenzanilinverbindungen |
| CH495111A (de) * | 1968-03-14 | 1970-08-31 | Ciba Geigy | Schädlingsbekämpfungsmittel |
-
1984
- 1984-06-26 IT IT21608/84A patent/IT1176321B/it active
-
1985
- 1985-05-08 DE DE8585105645T patent/DE3571394D1/de not_active Expired
- 1985-05-08 AT AT85105645T patent/ATE44463T1/de not_active IP Right Cessation
- 1985-05-08 EP EP85105645A patent/EP0166918B1/en not_active Expired
- 1985-05-10 JP JP9814285A patent/JPS6133143A/ja active Granted
- 1985-05-15 US US06/734,067 patent/US4631293A/en not_active Expired - Fee Related
- 1985-06-25 KR KR1019850004510A patent/KR920004457B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP0166918A3 (en) | 1986-06-11 |
| IT1176321B (it) | 1987-08-18 |
| DE3571394D1 (en) | 1989-08-17 |
| JPH0153859B2 (ko) | 1989-11-15 |
| KR920004457B1 (ko) | 1992-06-05 |
| EP0166918B1 (en) | 1989-07-12 |
| JPS6133143A (ja) | 1986-02-17 |
| ATE44463T1 (de) | 1989-07-15 |
| EP0166918A2 (en) | 1986-01-08 |
| US4631293A (en) | 1986-12-23 |
| IT8421608A1 (it) | 1985-12-26 |
| IT8421608A0 (it) | 1984-06-26 |
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| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
| NORF | Unpaid initial registration fee |