KR850004458A - 아제티디논의 제조방법 - Google Patents

아제티디논의 제조방법 Download PDF

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Publication number
KR850004458A
KR850004458A KR1019840008368A KR840008368A KR850004458A KR 850004458 A KR850004458 A KR 850004458A KR 1019840008368 A KR1019840008368 A KR 1019840008368A KR 840008368 A KR840008368 A KR 840008368A KR 850004458 A KR850004458 A KR 850004458A
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KR
South Korea
Prior art keywords
aryl
alkoxy
formula
compound
dimethoxybenzyl
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KR1019840008368A
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English (en)
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KR910005230B1 (ko
Inventor
요시하루 마에다
Original Assignee
구라바야시 이꾸시로
다께다 야꾸힝 고오교 가부시끼가이샤
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Application filed by 구라바야시 이꾸시로, 다께다 야꾸힝 고오교 가부시끼가이샤 filed Critical 구라바야시 이꾸시로
Publication of KR850004458A publication Critical patent/KR850004458A/ko
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Publication of KR910005230B1 publication Critical patent/KR910005230B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

아제티디논의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 하기 일반식(Ⅱ)의 화합물을 하기 일반식(Ⅲ)의 화합물 또는 그의 염과 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 아제티디논의 제조방법.
    상기식중, R·O·CO는 아미노기 보호기이고; R2는 이미노 화합물의 질소원자의 보호기이며; R3는 탄소원자를 통해 결합되는 유리잔기이고; CO·OR1은 에스테르화 카르복실기이다.)
  2. 제1항에 있어서, R이 C6∼10아릴 또는 C7∼11아르알킬인 방법.
  3. 제1항에 있어서, R이 벤질인 방법.
  4. 제1항에 있어서, R1이 C1∼4인 알킬인 방법.
  5. 제1항에 있어서, R2가 트리-(C1∼4알킬)실릴, C7∼11아르알킬, 디-(C6∼10아릴)메틸, 트리-(C6∼10아릴)메틸, 모노-(C1∼4알콕시)-C7∼아11르알킬, 디-(C1∼4알콕시-C7∼11아르알킬, 모노-(C1∼4알콕시)-C6∼10아릴, 디-(C1∼4-알콕시)-C6∼10아릴, 디-[모노-(C1∼4알콕시)-C6∼10아릴]메틸, 디-[디-(C1∼4알콕시)-C6∼10아릴]메틸 또는 C3∼6알켄-2-일인방법.
  6. 제1항에 있어서, R2가 벤질 또는 디메톡시벤질인 방법.
  7. 제1항에 있어서, R2가 2-3-디메톡시벤질인 방법.
  8. 제1항에 있어서, R2가 3,4-디메톡시벤질인 방법.
  9. 제1항에 있어서, R3가 C6∼10아릴, C7∼11아르알킬 또는 산소, 황 및 질소 원자중에서 선택된 1∼4헤테로원자를 함유하는 5- 또는 6-원 헤테로고리기인 방법.
  10. 제1항에 있어서, R3가 (R)-2,2-디메틸-1,3-디옥솔란-4-일인방법.
  11. 제1항에 있어서, R이 벤질, R1이 에틸, R2가 2,4-디메톡시벤질이고 R3가 (R)-2,2-디메틸-1,3-디옥솔란-4-일인방법.
  12. 아미노 보호된 글리신 또는 그의 염을 염기존재하에 알킬 할로게노카르보네이트와 반응시켜서 제조한 반응혼합물을 하기 일반식(Ⅲ)의 화합물과 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 아제티디논의 제조방법.
    (상기 식중, R·O·CO는 아미노기 보호기이고; R2는 이미노 화합물의 질소원자의 보호기이며; R3는 탄소원자를 통해 결합하는 유리잔기이다.
  13. 제12항에 있어서, 아미노 보호된 글리신이 N-카르보벤족시글리신인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840008368A 1983-12-27 1984-12-27 아제티디논의 제조방법 KR910005230B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP251626 1983-12-27
JP58251626A JPS60139667A (ja) 1983-12-27 1983-12-27 アゼチジノンの製造法
JP251626/83 1983-12-27

Publications (2)

Publication Number Publication Date
KR850004458A true KR850004458A (ko) 1985-07-15
KR910005230B1 KR910005230B1 (ko) 1991-07-24

Family

ID=17225619

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840008368A KR910005230B1 (ko) 1983-12-27 1984-12-27 아제티디논의 제조방법

Country Status (11)

Country Link
EP (1) EP0146900A3 (ko)
JP (1) JPS60139667A (ko)
KR (1) KR910005230B1 (ko)
CN (1) CN85101823A (ko)
AU (1) AU571627B2 (ko)
CA (1) CA1259322A (ko)
DK (2) DK605384A (ko)
HU (1) HU193730B (ko)
IL (1) IL73861A (ko)
NZ (1) NZ210718A (ko)
ZA (1) ZA849898B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK411384A (da) * 1983-10-03 1985-04-04 Hoffmann La Roche Fremgangsmaade til fremstilling af azetidinonderivater
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5284864A (en) 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
KR20050044621A (ko) 2001-11-30 2005-05-12 브리스톨-마이어스 스큅 컴퍼니 파클리탁셀 용매화물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52106857A (en) * 1976-01-05 1977-09-07 Fujisawa Pharmaceut Co Ltd Preparation of 1,3-disubstituted-2-azetidinones
CA1262128A (en) * 1981-08-27 1989-10-03 Christian N. Hubschwerlen .beta.-lactams
DK411384A (da) * 1983-10-03 1985-04-04 Hoffmann La Roche Fremgangsmaade til fremstilling af azetidinonderivater
US4751299A (en) * 1983-11-18 1988-06-14 Takeda Chemical Industries, Ltd. Optically active β-lactams and method of their production
EP0146735A1 (de) * 1983-11-23 1985-07-03 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Optisch einheitliche beta-Lactame

Also Published As

Publication number Publication date
EP0146900A2 (en) 1985-07-03
DK605384A (da) 1985-06-28
AU571627B2 (en) 1988-04-21
JPS60139667A (ja) 1985-07-24
AU3720284A (en) 1985-07-04
CA1259322A (en) 1989-09-12
CN85101823A (zh) 1987-01-10
DK605384D0 (da) 1984-12-18
ZA849898B (en) 1986-08-27
EP0146900A3 (en) 1988-03-30
IL73861A0 (en) 1985-03-31
DK175290A (da) 1990-07-23
NZ210718A (en) 1987-11-27
IL73861A (en) 1988-07-31
HUT36452A (en) 1985-09-30
HU193730B (en) 1987-11-30
KR910005230B1 (ko) 1991-07-24
DK175290D0 (da) 1990-07-23

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