KR840009310A - 디벤조디아제핀 유도체의 제조방법 - Google Patents
디벤조디아제핀 유도체의 제조방법 Download PDFInfo
- Publication number
- KR840009310A KR840009310A KR1019840002660A KR840002660A KR840009310A KR 840009310 A KR840009310 A KR 840009310A KR 1019840002660 A KR1019840002660 A KR 1019840002660A KR 840002660 A KR840002660 A KR 840002660A KR 840009310 A KR840009310 A KR 840009310A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- group
- lower alkyl
- defined above
- hydrogen
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
내용없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (13)
- 일반식(XXIII)의 화합물을 루이스산의 존재중에서 R5R6NH,CH2(CH2)nNR|7R8, (여기서, R5,R6,R7,R8,R9,R10및 n은 하기 정의한 바와 같다)로 구성된 그룹중에서 선택한 화합물과 반응시킴을 특징으로 하여 일반식(I)의 화합물 및 그의 약제학적으로 허용되는 산 부가염을 제조하는 방법.상기식에서 X 및 Y는 동일 또는 상이하며, 각각 수소, 할로겐, CF3, 저급 알콕시, 저급알킬티오 또는 저급 알킬설포닐이고 ;R1은 R2와 R3와 결합하여 -(CH2)m-CH2-|그룹(여기서 m은 1 또는 2이다)또는 -CH=CH-그룹을 형성하는 경우에는 수소이며;R3는 R1이 R2와 결합하여 -(CH2)m-CH2-|그룹(여기서 m은 1또는 2이다) 또는- CH=CH-그룹을 형성하는 경우에 수소이고;R4는 NR5R6, (CH2)nNR7R8, |또는이며, 여기서 R5는 수소 또는 저급 알킬이고, R6은 수소 또는 저급 알킬이며, R7및 R8은 저급 알킬이고, n은 2또는 3이며, R9는 저급 알킬이고, R10은 저급알킬, 페닐, 할로겐, CF3, 저급알킬, 저급알콕시 또는 저급 알킬티오로 치환된 페닐, 벤질, 페닐그룹이 할로겐, CF3, 저급알킬, 저급알콕시 또는 저급 알킬티오로 치환된 벤질, 또는 CO2R11(여기서, R11은 저급알킬이다)이다.
- 제1항에 있어서, 일반식('a)의 화합물 및 그의 약제학적으로 허용되는 산부가염을 제조하는 방법.상기식에서 R4,X 및 Y는 상기 정의한 바와 같다.
- 제1항에 있어서, 일반식(I b)의 화합물 및 그의 약제학적으로 허용되는 산부가염을 제조하는 방법.상기식에서 R4,X 및 Y는 상기 정의한 바와 같다.
- 제1항에 있어서, 일반식(I c)의 화합물 및 그의 약제학적으로 허용되는 산부 가염을 제조하는 방법.상기식에서 R44,X 및 Y는 상기 정의한 바와 같다.
- 제1항에 있어서, 일반식(I d)의 화합물 및 그의 약제학적으로 허용되는 산 부가염을 제조하는 방법.상기식에서 R4,X 및 Y는 상기 정의한 바와 같다.
- 제2항 내지 5항중 어느 하나에 있어서, R4가 NR5R6또는 (CH2)nNR|7R8그룹(여기서, R5,R6,R7,R8및 n은 상기 정의한 바와 같다)인 방법.
- 제2항 내지 5항중 어느 하나에 있어서, R4가또는(여기서, R9및 R10은 상기 정의한 바와 같다)인 방법.
- 제7항에 있어서, R4가(여기서, R10은 상기 정의한 바와 같다)인 방법.
- 제1항에 있어서, 루이스산을 사염화티탄, 염화알루미늄, 브롬화아연, 염와 제2천 및 염화 제2주석으로 이루어진 그룹중에서 선택하는 방법.
- 제9항에 있어서, 루이스산이 사염화티탄인 방법.
- 제1항에 있어서, 용매를 사용하는 방법.
- 제11항에 있어서, 벤젠, 톨루엔 및 크실렌으로 이루어진 그룹중에서 선택된 용매를 사용하는 방법.
- 제12항에 있어서, 벤젠을 사용하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US495569 | 1983-05-18 | ||
US06/495,569 US4761411A (en) | 1983-05-18 | 1983-05-18 | Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses |
Publications (1)
Publication Number | Publication Date |
---|---|
KR840009310A true KR840009310A (ko) | 1984-12-26 |
Family
ID=23969143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840002660A KR840009310A (ko) | 1983-05-18 | 1984-05-16 | 디벤조디아제핀 유도체의 제조방법 |
Country Status (16)
Country | Link |
---|---|
US (1) | US4761411A (ko) |
EP (1) | EP0129692A3 (ko) |
JP (1) | JPS59219285A (ko) |
KR (1) | KR840009310A (ko) |
AU (1) | AU575830B2 (ko) |
CA (1) | CA1244414A (ko) |
DK (1) | DK246984A (ko) |
ES (1) | ES532509A0 (ko) |
FI (1) | FI77865C (ko) |
GR (1) | GR82273B (ko) |
HU (1) | HU193010B (ko) |
IL (1) | IL71856A0 (ko) |
NZ (1) | NZ208180A (ko) |
PH (1) | PH21087A (ko) |
PT (1) | PT78599B (ko) |
ZA (1) | ZA843722B (ko) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4840947A (en) * | 1986-10-14 | 1989-06-20 | Hoechst-Roussel Pharmaceuticals, Inc. | Antiinflammatory and analgesic piperidin-4-yl-tetracyclic benzodiazepines and use thereas |
US4751223A (en) * | 1986-10-14 | 1988-06-14 | Hoechst-Roussel Pharmaceuticals, Inc. | Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiazepines |
US5008262A (en) * | 1988-04-19 | 1991-04-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating trichotillomania and onchyphagia |
US4929615A (en) * | 1989-06-12 | 1990-05-29 | Hoechst-Roussel Pharmaceuticals Inc. | 7H-benzo[b]pyrazino[1,2-d]pyrrolo[3,2,1-jk][1,4]benzodiazepines |
US5312819A (en) * | 1990-08-20 | 1994-05-17 | Sandoz Ltd. | Pharmaceutical compositions comprising clozapine and a radical scavenger |
US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
WO1997016430A1 (en) * | 1995-11-01 | 1997-05-09 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
EP1954696B1 (en) | 2005-01-19 | 2011-02-23 | Bristol-Myers Squibb Company | 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders |
WO2007002634A1 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
DE602006017694D1 (de) | 2005-06-27 | 2010-12-02 | Bristol Myers Squibb Co | C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden |
EP1896417B1 (en) | 2005-06-27 | 2011-03-23 | Bristol-Myers Squibb Company | Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
KR20080027890A (ko) | 2005-06-27 | 2008-03-28 | 브리스톨-마이어스 스큅 컴퍼니 | 혈전성 증상의 치료에 유용한 p2y1 수용체의 n-연결헤테로시클릭 길항제 |
US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
US9453021B2 (en) | 2011-05-10 | 2016-09-27 | Kyowa Hakko Kirin Co., Ltd. | Pyrimidodiazepinone compound |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2733371A (en) * | 1970-04-14 | 1972-10-12 | A. H. Robins Company, Incorporated | 5, 7-DISUBSTITUTED-l, 9-ALKYLENE-l, 4-BENZODIAZEPIN-2 ONES |
GB1451389A (en) * | 1974-07-03 | 1976-09-29 | Pierrel Spa | Indolobenzazepines |
US4192874A (en) * | 1978-11-02 | 1980-03-11 | American Hoechst Corporation | Substituted 1,2,6,7-tetrahydroindolo[1,7-ab][1,5]benzodiazepines |
US4186199A (en) * | 1978-11-02 | 1980-01-29 | American Hoechst Corporation | Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines |
IE57646B1 (en) * | 1983-12-16 | 1993-02-10 | Wyeth John & Brother Ltd | Derivatives of imidazoquinolines and analogues thereof |
GB8333581D0 (en) * | 1983-12-16 | 1984-01-25 | Wyeth John & Brother Ltd | Heterocyclic compounds |
-
1983
- 1983-05-18 US US06/495,569 patent/US4761411A/en not_active Expired - Fee Related
-
1984
- 1984-05-14 HU HU841858A patent/HU193010B/hu not_active IP Right Cessation
- 1984-05-15 EP EP84105509A patent/EP0129692A3/en not_active Withdrawn
- 1984-05-16 FI FI841965A patent/FI77865C/fi not_active IP Right Cessation
- 1984-05-16 PH PH30678A patent/PH21087A/en unknown
- 1984-05-16 GR GR74738A patent/GR82273B/el unknown
- 1984-05-16 KR KR1019840002660A patent/KR840009310A/ko not_active Application Discontinuation
- 1984-05-16 ES ES532509A patent/ES532509A0/es active Granted
- 1984-05-16 NZ NZ208180A patent/NZ208180A/en unknown
- 1984-05-17 PT PT78599A patent/PT78599B/pt unknown
- 1984-05-17 IL IL71856A patent/IL71856A0/xx unknown
- 1984-05-17 CA CA000454542A patent/CA1244414A/en not_active Expired
- 1984-05-17 DK DK246984A patent/DK246984A/da not_active Application Discontinuation
- 1984-05-17 AU AU28347/84A patent/AU575830B2/en not_active Ceased
- 1984-05-17 JP JP59097691A patent/JPS59219285A/ja active Pending
- 1984-05-17 ZA ZA843722A patent/ZA843722B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
FI841965A0 (fi) | 1984-05-16 |
US4761411A (en) | 1988-08-02 |
ZA843722B (en) | 1985-01-30 |
AU575830B2 (en) | 1988-08-11 |
DK246984D0 (da) | 1984-05-17 |
EP0129692A3 (en) | 1987-07-29 |
DK246984A (da) | 1984-11-19 |
FI77865C (fi) | 1989-05-10 |
NZ208180A (en) | 1988-01-08 |
HUT37432A (en) | 1985-12-28 |
FI841965A (fi) | 1984-11-19 |
GR82273B (ko) | 1984-12-13 |
HU193010B (en) | 1987-08-28 |
ES8506652A1 (es) | 1985-08-01 |
PT78599A (en) | 1984-06-01 |
PH21087A (en) | 1987-07-16 |
EP0129692A2 (en) | 1985-01-02 |
JPS59219285A (ja) | 1984-12-10 |
FI77865B (fi) | 1989-01-31 |
ES532509A0 (es) | 1985-08-01 |
CA1244414A (en) | 1988-11-08 |
PT78599B (en) | 1986-07-17 |
AU2834784A (en) | 1984-11-22 |
IL71856A0 (en) | 1984-09-30 |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |