KR840004069A - 시클로알카[c] 피롤카복실산 유도체의 제조방법 - Google Patents

시클로알카[c] 피롤카복실산 유도체의 제조방법 Download PDF

Info

Publication number
KR840004069A
KR840004069A KR1019830001244A KR830001244A KR840004069A KR 840004069 A KR840004069 A KR 840004069A KR 1019830001244 A KR1019830001244 A KR 1019830001244A KR 830001244 A KR830001244 A KR 830001244A KR 840004069 A KR840004069 A KR 840004069A
Authority
KR
South Korea
Prior art keywords
formula
compound
hydrogen
radical
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019830001244A
Other languages
English (en)
Korean (ko)
Inventor
헨닝 라이너
Original Assignee
하인리히 벡커, 베른하르트 벡크
훽스트 아크티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 하인리히 벡커, 베른하르트 벡크, 훽스트 아크티엔 게젤샤프트 filed Critical 하인리히 벡커, 베른하르트 벡크
Publication of KR840004069A publication Critical patent/KR840004069A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019830001244A 1982-03-30 1983-03-28 시클로알카[c] 피롤카복실산 유도체의 제조방법 Ceased KR840004069A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823211676 DE3211676A1 (de) 1982-03-30 1982-03-30 Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211676.4 1982-03-30

Publications (1)

Publication Number Publication Date
KR840004069A true KR840004069A (ko) 1984-10-06

Family

ID=6159702

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830001244A Ceased KR840004069A (ko) 1982-03-30 1983-03-28 시클로알카[c] 피롤카복실산 유도체의 제조방법

Country Status (17)

Country Link
EP (1) EP0090362A3 (enExample)
JP (1) JPS58177967A (enExample)
KR (1) KR840004069A (enExample)
AU (1) AU560124B2 (enExample)
CA (1) CA1198118A (enExample)
DE (1) DE3211676A1 (enExample)
DK (1) DK144783A (enExample)
ES (2) ES521041A0 (enExample)
FI (1) FI831049L (enExample)
GR (1) GR78157B (enExample)
HU (1) HU193876B (enExample)
IL (1) IL68267A (enExample)
NO (2) NO831168L (enExample)
NZ (1) NZ203719A (enExample)
PH (1) PH19003A (enExample)
PT (1) PT76472B (enExample)
ZA (1) ZA832229B (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
US5175306A (en) * 1983-01-31 1992-12-29 Hoechst Aktiengesellschaft Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
FR2546886B2 (fr) * 1983-06-06 1986-05-16 Adir Derives d'acides isoindoledicarboxyliques, leur preparation et compositions pharmaceutiques les contenant
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3410732A1 (de) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt Methode zur behandlung des glaukoms
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
WO1986000896A1 (en) * 1984-07-30 1986-02-13 Schering Corporation NOVEL PROCESS FOR THE PREPARATION OF CIS, ENDOOCTAHYDROCYCLOPENTA ADb BDPYRROLE-2-CARBOXYLATE
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) * 1986-11-21 1988-06-01 Hoechst Ag Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
DE3839127A1 (de) * 1988-11-19 1990-05-23 Hoechst Ag Pyrrolidon-2-carbonsaeure-derivate mit psychotroper wirkung
DD284030A5 (de) 1988-11-24 1990-10-31 Hoechst Ag,De Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE59706273D1 (de) 1996-03-20 2002-03-21 Hoechst Ag Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
CZ298749B6 (cs) 1996-10-18 2008-01-16 Vertex Pharmaceuticals Incorporated Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
TW201127828A (en) 2003-09-05 2011-08-16 Vertex Pharma Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
US8399615B2 (en) 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
SG2014013338A (en) * 2005-08-19 2014-06-27 Vertex Pharma Processes and intermediates
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
CA2643688A1 (en) 2006-02-27 2007-08-30 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
US20070225297A1 (en) 2006-03-16 2007-09-27 Perni Robert B Deuterated hepatitis C protease inhibitors
MX2009009182A (es) 2007-02-27 2009-09-04 Vertex Pharma Co-cristales y composiciones farmaceuticas que los comprenden.
EP2134717A2 (en) 2007-02-27 2009-12-23 Vertex Pharmceuticals Incorporated Inhibitors of serine proteases
NZ583699A (en) 2007-08-30 2012-04-27 Vertex Pharma Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same
AU2009271325A1 (en) 2008-06-24 2010-01-21 Merck Sharp & Dohme Corp. Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
JP5829529B2 (ja) * 2011-08-29 2015-12-09 日本曹達株式会社 光学活性４級アンモニウム塩、および光学活性化合物の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE3276311D1 (en) * 1981-02-17 1987-06-19 Warner Lambert Co Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
ZA826022B (en) * 1981-08-21 1983-08-31 Univ Miami Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
EP0081094A1 (en) * 1981-11-12 1983-06-15 Merck & Co. Inc. Substituted omega-amino-carboxymethyldipeptide antihypertensive agents
EP0088350B1 (en) * 1982-03-08 1985-02-20 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
GR78157B (enExample) 1984-09-26
DK144783A (da) 1983-10-01
ES8401937A1 (es) 1984-01-01
NZ203719A (en) 1986-02-21
PH19003A (en) 1985-12-03
EP0090362A3 (de) 1985-09-18
JPS58177967A (ja) 1983-10-18
ZA832229B (en) 1983-12-28
FI831049A0 (fi) 1983-03-28
AU560124B2 (en) 1987-04-02
DE3211676A1 (de) 1983-10-06
ES521741A0 (es) 1984-02-01
NO831168L (no) 1983-10-03
CA1198118A (en) 1985-12-17
AU1297083A (en) 1983-10-06
IL68267A (en) 1987-03-31
FI831049A7 (fi) 1983-10-01
PT76472A (de) 1983-04-01
HU193876B (en) 1987-12-28
FI831049L (fi) 1983-10-01
EP0090362A2 (de) 1983-10-05
ES8402570A1 (es) 1984-02-01
NO834352L (no) 1983-10-03
IL68267A0 (en) 1983-06-15
ES521041A0 (es) 1984-01-01
DK144783D0 (da) 1983-03-29
PT76472B (de) 1986-01-24

Similar Documents

Publication Publication Date Title
KR840004069A (ko) 시클로알카[c] 피롤카복실산 유도체의 제조방법
FR2421874A1 (fr) Carboxyalkylacylamino-acides utiles comme agents hypotenseurs
FR2384753A1 (fr) Nouveaux thiols et leur procede de preparation
GB1422518A (en) 11-deoxyprostaglandin derivatives and process therefor
MY102277A (en) Quinoline compounds
FR2363563A1 (fr) Nouveaux derives de 1-acyloxymethyl-5-fluorouracile utiles notamment comme agents antitumoraux, et leur procede de preparation
AU568301B2 (en) Pharmaceutical preparations containing (+)-cyanidan-3-ol derivatives and processes for producing them
ATE78269T1 (de) Elektrotauchlack.
FR2373546A1 (fr) Derives thio-oxime de cephalosporines et de penicillines, utiles comme inhibiteurs de b-lactamases
FR2356626A1 (fr) Acides ureidoacetohydroxamiques substitues
FR2434140A1 (fr) Nouveaux composes phenoliques utilisables comme stabilisants de matieres organiques et leur preparation
GB1473602A (enExample)
KR870007142A (ko) 이환 화합물의 제조방법
FR2359116A1 (fr) N-alkyldiphenylamines
FR2414497A1 (fr) Analogues de betah-endorphine et procede pour leur preparation
FR2367062A1 (fr) Derives 1-(n-acylcarbamoyl) 2-cyano-aziridines ayant une action cancerostatique et immunostimulatrice et procede pour leur preparation
FR2445838A1 (fr) Nouveaux 1a,3b-dihydroxy-5-steroides
FI851353L (fi) Foerfarande foer syntetisering av estrar.
FR2378788A1 (fr) Derives de cephalosporine et leur procede de fabrication
KR880000377A (ko) 트란스 헥사하이드로 테레프탈산 에스테르 유도체의 제조방법
DE3871316D1 (de) Verfahren zur herstellung von 3-amino-1-benzyl-pyrrolidinen.
KR830001890A (ko) 카바졸 유도체의 제조방법
FR2399402A1 (fr) Nouveaux composes carbonyles aliphatiques et leur preparation
KR850007247A (ko) 바이페닐릴설포닐 우레아의 제조방법
ATE3878T1 (de) Verfahren zur herstellung von 11-betahydroxysteroiden.

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19830328

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19880213

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19830328

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19900428

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19900713

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19900428

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I