KR840002402A - 1-옥사데티아-세펨유도체의 제조법 - Google Patents
1-옥사데티아-세펨유도체의 제조법 Download PDFInfo
- Publication number
- KR840002402A KR840002402A KR1019820005346A KR820005346A KR840002402A KR 840002402 A KR840002402 A KR 840002402A KR 1019820005346 A KR1019820005346 A KR 1019820005346A KR 820005346 A KR820005346 A KR 820005346A KR 840002402 A KR840002402 A KR 840002402A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- formula
- general formula
- derivative
- compound
- Prior art date
Links
- 125000002252 acyl group Chemical group 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 150000008049 diazo compounds Chemical class 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 125000003435 aroyl group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 1
- 239000010977 jade Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- -1 phenoxymethyl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229910052703 rhodium Inorganic materials 0.000 claims 1
- 239000010948 rhodium Substances 0.000 claims 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims 1
- 229910001923 silver oxide Inorganic materials 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cephalosporin Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 다음 일반식(II)의 디아조합물을 카르벤도입축매와 반응시켜 폐환(ring-cloeed)시킴을 특징으로 하는 다음 일반식(III)의 1-옥사 데티아-세펨유도체의 제조법.위 식에서 A는 아실기, R1은 수소 또는 메톡시기, R2는 카르복시보호기이다.
- 다음 일반식(II)의 디아조화합물을 카르벤도입축매와 반응시켜 폐환시킴으로써 다음 일반식(III)의 1-옥사-1-데피아-3-히드록시세팔로스포린유도체를 생성하여 일반식(III)의 유도체의 3위 히드록시기를 알킬화제(alkylation reagent)와 반응시킴을 특징으로 하는 일반식(I)의 1-옥사데티아세펨유도체의 제조법.
- 제1항 또는 제2항에 있어서, 일반식(II)의 화합물에서 아실기 A는 식 R4CO-(R4는 아릴기, 특히 페닐기임)의 아로일기, 또는 R6CO-(R6는 아랄킬기, 특히 벤질기 또는 페녹시메틸기임)의 아실기임을 특징으로 하는 일반식(I)의 1-옥사데티아-세펨유도체의 제조법.
- 제1항 또는 제2항에 있어서, 카르벤도입축매는 일반식(II) 화합물에서 디아조기(N2)가 결합되는 있는 탄소원자를 카르벤으로 전화할 수 있는 물질, 특히 모듐 아세테이프, 로듐옥시드 또는 산화은임을 특징으로 하는 일반식(I)의 1-옥사데리아-세펨유도체의 제조법.
- 다음 일반식(II)로 표시되는 새로운 유용한 디아조화합물을 출발화합물로서 사용함을 특징으로 하는 1-옥사데티아-세펨유도체의 제조법.위 식에서 A는 아실기 R1은 수소원자 또는 메톡시기, R2는 카르복시보호기이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56198466A JPS58103391A (ja) | 1981-12-11 | 1981-12-11 | １−オキサデチア−セフエム誘導体の製造法 |
| JP198466 | 1981-12-11 | ||
| JP56-198466 | 1981-12-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840002402A true KR840002402A (ko) | 1984-07-02 |
| KR880002089B1 KR880002089B1 (ko) | 1988-10-15 |
Family
ID=16391570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR8205346A KR880002089B1 (ko) | 1981-12-11 | 1982-11-27 | 1-옥사데티아-세펨유도체의 제조방법 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0081824B1 (ko) |
| JP (1) | JPS58103391A (ko) |
| KR (1) | KR880002089B1 (ko) |
| DE (1) | DE3267837D1 (ko) |
| PH (1) | PH20594A (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5936684A (ja) * | 1982-08-24 | 1984-02-28 | Shionogi & Co Ltd | １−オキサセフアム化合物の製造方法 |
| EP0133670A3 (de) * | 1983-08-09 | 1985-12-18 | Bayer Ag | Verfahren zur Herstellung von 7-Acylamino-3-hydrocy-cephem-4-carbonsäuren und 7-Acylamino-3-hydroxy-1-de-thia-1-oxacephem-4-carbonsäuren |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1592245A (en) * | 1976-08-09 | 1981-07-01 | Shionogi & Co | Intermediates for cephalosporin analogues |
| US4174316A (en) * | 1978-08-14 | 1979-11-13 | Merck & Co., Inc. | 4-Iodomethylazetidin-2-one |
-
1981
- 1981-12-11 JP JP56198466A patent/JPS58103391A/ja active Granted
-
1982
- 1982-11-27 KR KR8205346A patent/KR880002089B1/ko active
- 1982-12-07 PH PH28241A patent/PH20594A/en unknown
- 1982-12-10 DE DE8282111454T patent/DE3267837D1/de not_active Expired
- 1982-12-10 EP EP82111454A patent/EP0081824B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58103391A (ja) | 1983-06-20 |
| PH20594A (en) | 1987-02-24 |
| EP0081824A1 (en) | 1983-06-22 |
| KR880002089B1 (ko) | 1988-10-15 |
| JPH0222757B2 (ko) | 1990-05-21 |
| DE3267837D1 (en) | 1986-01-16 |
| EP0081824B1 (en) | 1985-12-04 |
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