KR830009051A - 치환된 테트라 히드로피리미디는 유도체의 제조방법 - Google Patents
치환된 테트라 히드로피리미디는 유도체의 제조방법 Download PDFInfo
- Publication number
- KR830009051A KR830009051A KR1019820000751A KR820000751A KR830009051A KR 830009051 A KR830009051 A KR 830009051A KR 1019820000751 A KR1019820000751 A KR 1019820000751A KR 820000751 A KR820000751 A KR 820000751A KR 830009051 A KR830009051 A KR 830009051A
- Authority
- KR
- South Korea
- Prior art keywords
- reaction
- formula
- alkali metal
- carried out
- reacting
- Prior art date
Links
- 238000000034 method Methods 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 239000012948 isocyanate Substances 0.000 claims 2
- 150000002513 isocyanates Chemical class 0.000 claims 2
- -1 α-naphthyl group Chemical group 0.000 claims 2
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 claims 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims 1
- 150000008041 alkali metal carbonates Chemical class 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- HCUYBXPSSCRKRF-UHFFFAOYSA-N diphosgene Chemical compound ClC(=O)OC(Cl)(Cl)Cl HCUYBXPSSCRKRF-UHFFFAOYSA-N 0.000 claims 1
- 230000002140 halogenating effect Effects 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 150000003512 tertiary amines Chemical class 0.000 claims 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical group [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 claims 1
- 150000005326 tetrahydropyrimidines Chemical class 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- a) 일반식(II)의 화합물을 일반식(III)의 이소시아네이트(여기에서 Aγ은 일반식(II)의 Aγ과 같거나 다름)와 반응시켜서 생성된 화합물을 할로겐화제와 반응시킨 후 알카리금속 수산화물과 반응시키거나, b) 일반식(IV)의 화합물을 일반식(III)의 이소시아네이트(여기에서 Aγ은 일반식(IV)의 Aγ과 같거나 다름)와 반응시켜서 생성된 화합물을 알카리금속 수산화물과 반응시키거나, c) 일반식(V)의 화합물을 카보닐클로라이드 또는 트리클로로메틸 클로로포르메이트와 반응시켜 일반식(I)의 치환된 테트라히드로 피리미디는 유도체를 제조하는 방법.상기식에서 Aγ은 같거나 서로 다르며 각각 α-나프틸 그룹 또는(여기에서 X는 할로겐, 저급알킬, 저급알콕시, 니트로, 시아노, 저급알킬카보닐, 저급알콕시카보닐, 트리플루오로메틸 또는 페녹시이고,n은 0,1,2 또는 3이고, n이 2 또는 3인 경우 X는 각각 서로 다르다)이다.Y는 할로겐이다.
- 제1(b)항에 있어서, 반응을 촉매(예를 들면 4급 암모늄염) 존재하에서 진행시키는 방법.
- 제2항에 있어서 촉매가 테트라 부틸 암모늄 브로마이드인 제조방법.
- 제1(c)항에 있어서 반응을 산결합제 존재하에 수행하는 방법.
- 제4항에 있어서, 산결합제가 알칼리금속 수산화물, 알칼리금속탄산염, 알칼리금속 중탄산염, 알칼리금속 알콜레이트 및 3급 아민중에서 선택된 제조방법.
- 제1 내지 5항에 있어서, 반응을 희석제 존재하에 수행하는 방법.
- 제6항에 있어서, 반응을 희석제로서 물 및/또는 하나 이상의 불활성 유기용매 존재하에 수행하는 방법.
- 제1 내지 7항에 있어서, 반응을 -20℃ 내지 반응혼합물의 비점에서 수행하는 방법.
- 제8항에 있어서, 반응을 0˚내지 100℃에서 수행하는 방법.
- 제1 내지 9항에 있어서, 반응물이 상술한 바와 같이 특정한 것인 제조방법.
- 제1항에 있어서, 실시예 1 내지 62에 기술된 방법으로 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56023122A JPS57139069A (en) | 1981-02-20 | 1981-02-20 | Substituted tetrahydropyrimidinone derivative, its preparation and herbicide |
| JP56-23122 | 1981-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830009051A true KR830009051A (ko) | 1983-12-17 |
Family
ID=12101692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019820000751A KR830009051A (ko) | 1981-02-20 | 1982-02-20 | 치환된 테트라 히드로피리미디는 유도체의 제조방법 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4402731A (ko) |
| EP (1) | EP0058868B1 (ko) |
| JP (1) | JPS57139069A (ko) |
| KR (1) | KR830009051A (ko) |
| AR (1) | AR228768A1 (ko) |
| AT (1) | ATE7027T1 (ko) |
| AU (1) | AU548087B2 (ko) |
| BR (1) | BR8200916A (ko) |
| CA (1) | CA1166250A (ko) |
| CS (1) | CS231991B2 (ko) |
| DD (1) | DD202374A5 (ko) |
| DE (1) | DE3260098D1 (ko) |
| DK (1) | DK74182A (ko) |
| ES (1) | ES8307003A1 (ko) |
| GR (1) | GR75868B (ko) |
| HU (1) | HU187447B (ko) |
| IL (1) | IL65039A (ko) |
| PH (1) | PH17047A (ko) |
| PL (1) | PL235150A1 (ko) |
| PT (1) | PT74412B (ko) |
| TR (1) | TR20938A (ko) |
| ZA (1) | ZA821101B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2975456A (en) * | 1956-08-03 | 1961-03-21 | Gen Electric | Vacuum cleaning nozzle attachment for high pile rugs |
| JPS58140078A (ja) * | 1982-02-16 | 1983-08-19 | Nippon Tokushu Noyaku Seizo Kk | メチル置換テトラヒドロ−２−ピリミジノン誘導体、その製法、その中間体及び該中間体の製法、並びに除草剤 |
| DE3709574A1 (de) * | 1987-03-24 | 1988-10-06 | Bayer Ag | Substituierte triazolinone |
| DE19962923A1 (de) * | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Benzoylcyclohexandione |
| AU2003256755A1 (en) * | 2002-07-24 | 2004-02-09 | Ptc Therapeutics, Inc. | Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations |
| US9181261B2 (en) | 2012-05-22 | 2015-11-10 | Merck Sharp & Dohme Corp. | TrkA kinase inhibitors, compositions and methods thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3551425A (en) * | 1967-07-01 | 1970-12-29 | Basf Ag | Production of 2-oxohexahydropyrimidines |
| FR2194369B1 (ko) * | 1972-08-04 | 1980-04-25 | Roussel Uclaf | |
| IT1026907B (it) * | 1974-12-10 | 1978-10-20 | Snam Progetti | Procedimento per la sintesi di uree |
-
1981
- 1981-02-20 JP JP56023122A patent/JPS57139069A/ja active Pending
-
1982
- 1982-01-20 US US06/340,949 patent/US4402731A/en not_active Expired - Fee Related
- 1982-02-03 PH PH26823A patent/PH17047A/en unknown
- 1982-02-04 AU AU80184/82A patent/AU548087B2/en not_active Expired - Fee Related
- 1982-02-09 DE DE8282100905T patent/DE3260098D1/de not_active Expired
- 1982-02-09 AT AT82100905T patent/ATE7027T1/de not_active IP Right Cessation
- 1982-02-09 EP EP82100905A patent/EP0058868B1/de not_active Expired
- 1982-02-10 PT PT74412A patent/PT74412B/pt unknown
- 1982-02-11 DD DD82237349A patent/DD202374A5/de unknown
- 1982-02-17 IL IL65039A patent/IL65039A/xx unknown
- 1982-02-18 TR TR20938A patent/TR20938A/xx unknown
- 1982-02-18 GR GR67347A patent/GR75868B/el unknown
- 1982-02-19 DK DK74182A patent/DK74182A/da unknown
- 1982-02-19 AR AR288482A patent/AR228768A1/es active
- 1982-02-19 CS CS821170A patent/CS231991B2/cs unknown
- 1982-02-19 PL PL23515082A patent/PL235150A1/xx unknown
- 1982-02-19 ES ES509744A patent/ES8307003A1/es not_active Expired
- 1982-02-19 CA CA000396634A patent/CA1166250A/en not_active Expired
- 1982-02-19 BR BR8200916A patent/BR8200916A/pt unknown
- 1982-02-19 HU HU82513A patent/HU187447B/hu unknown
- 1982-02-19 ZA ZA821101A patent/ZA821101B/xx unknown
- 1982-02-20 KR KR1019820000751A patent/KR830009051A/ko unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK74182A (da) | 1982-08-21 |
| EP0058868A1 (de) | 1982-09-01 |
| CA1166250A (en) | 1984-04-24 |
| ES509744A0 (es) | 1983-06-16 |
| HU187447B (en) | 1986-01-28 |
| JPS57139069A (en) | 1982-08-27 |
| DD202374A5 (de) | 1983-09-14 |
| AU8018482A (en) | 1982-08-26 |
| ES8307003A1 (es) | 1983-06-16 |
| PT74412A (en) | 1982-03-01 |
| ZA821101B (en) | 1983-01-26 |
| BR8200916A (pt) | 1982-12-28 |
| GR75868B (ko) | 1984-08-02 |
| AU548087B2 (en) | 1985-11-21 |
| DE3260098D1 (en) | 1984-05-17 |
| CS117082A2 (en) | 1984-01-16 |
| US4402731A (en) | 1983-09-06 |
| AR228768A1 (es) | 1983-04-15 |
| PH17047A (en) | 1984-05-17 |
| TR20938A (tr) | 1983-01-20 |
| PT74412B (en) | 1983-07-08 |
| EP0058868B1 (de) | 1984-04-11 |
| ATE7027T1 (de) | 1984-04-15 |
| CS231991B2 (en) | 1985-01-16 |
| IL65039A (en) | 1984-12-31 |
| IL65039A0 (en) | 1982-04-30 |
| PL235150A1 (en) | 1983-04-11 |
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