KR830002779A - 결정성 에피머 항생물질 - Google Patents

결정성 에피머 항생물질 Download PDF

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Publication number
KR830002779A
KR830002779A KR1019800001756A KR800001756A KR830002779A KR 830002779 A KR830002779 A KR 830002779A KR 1019800001756 A KR1019800001756 A KR 1019800001756A KR 800001756 A KR800001756 A KR 800001756A KR 830002779 A KR830002779 A KR 830002779A
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KR
South Korea
Prior art keywords
epimer
solution
salt
precipitated
little
Prior art date
Application number
KR1019800001756A
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English (en)
Other versions
KR840000078B1 (ko
Inventor
쿠오샹 양
Original Assignee
아더 알. 웨일
일라이 릴리 앤드 캄파니
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Application filed by 아더 알. 웨일, 일라이 릴리 앤드 캄파니 filed Critical 아더 알. 웨일
Publication of KR830002779A publication Critical patent/KR830002779A/ko
Application granted granted Critical
Publication of KR840000078B1 publication Critical patent/KR840000078B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

결정성 에피머 항생물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 다음 구조식(Ⅱ)의 옥사 -β-락탐 이산 수용액에 아세톤을 가하고, 이 수성아세톤 용액에 수산화암모늄을 용액의 pH가 6내지 7.5로 될때까지 15°내지 30℃에서 가하고, 아세톤으로 담점까지 용액을 더 희석하고, L-에피머가 거의 없는 상기 디암모늄염의 D-에피머를 석출시키고 임의로, 고압 액체 크로마토그라피에 의해 석출된 D 디암모늄염의 농도를 높이고, 임의로, D-에피머의 농도를 높인 디암모늄염 수용액을 20℃ 내지 30℃에서 수혼화성 유기용매로 담점까지 희석하고, L-에피머가 거의 없는 D-에피머를 석출시켜 다음 구조식(Ⅰ)의 옥사 -β-락탐 항생물집의 D-디암모늄 염을 L-디암모늄염이 거의 없는 결정형으로 제조하는 방법.
  3. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800001756A 1979-05-01 1980-05-01 옥사-β-락탐 항생물질의 D-디암모늄염의 제조방법 KR840000078B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35037 1979-05-01
US06/035,037 US4252953A (en) 1979-05-01 1979-05-01 Antibiotic crystalline epimer

Publications (2)

Publication Number Publication Date
KR830002779A true KR830002779A (ko) 1983-05-30
KR840000078B1 KR840000078B1 (ko) 1984-02-08

Family

ID=21880235

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800001756A KR840000078B1 (ko) 1979-05-01 1980-05-01 옥사-β-락탐 항생물질의 D-디암모늄염의 제조방법

Country Status (34)

Country Link
US (1) US4252953A (ko)
EP (1) EP0018811B1 (ko)
JP (1) JPS55153788A (ko)
KR (1) KR840000078B1 (ko)
AR (1) AR230450A1 (ko)
AT (1) AT370108B (ko)
AU (1) AU538283B2 (ko)
BE (1) BE882980A (ko)
BG (1) BG34905A3 (ko)
CA (1) CA1138867A (ko)
CH (1) CH646434A5 (ko)
CS (1) CS226013B2 (ko)
DD (1) DD150352A5 (ko)
DE (1) DE3061751D1 (ko)
DK (1) DK177980A (ko)
EG (1) EG14719A (ko)
ES (1) ES8105316A1 (ko)
FI (1) FI801345A (ko)
FR (1) FR2455605A1 (ko)
GB (1) GB2047707B (ko)
GR (1) GR68202B (ko)
HU (1) HU184750B (ko)
IE (1) IE49775B1 (ko)
IL (1) IL59912A (ko)
IT (1) IT1141935B (ko)
LU (1) LU82411A1 (ko)
MY (1) MY8500601A (ko)
NZ (1) NZ193528A (ko)
PH (1) PH15596A (ko)
PL (1) PL125579B1 (ko)
PT (1) PT71140A (ko)
RO (1) RO79684A (ko)
SU (1) SU860705A3 (ko)
ZA (1) ZA802475B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS597193A (ja) * 1982-07-02 1984-01-14 Shionogi & Co Ltd マロニルメチル基の異性化方法
DE102004049396A1 (de) * 2003-10-08 2005-07-28 Behr Gmbh & Co. Kg Bauteil, insbesondere Hybridträger für ein Fahrzeug, und Verfahren zur Herstellung eines derartigen Bauteils sowie Verwendung eines derartigen Bauteils
US20070057535A1 (en) * 2003-10-08 2007-03-15 Behr Gmbh & Co.Kg Method and device for the production of a component, especially a hybrid component for a crossrail of a vehicle, component and use of said component

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR61146B (en) * 1976-03-25 1978-09-27 Shionogi & Co Preparation process of 1-oxadethiacephalosporins analogues
CA1085392A (en) * 1976-03-25 1980-09-09 Masayuki Narisada Arylmalonamido-1-oxadethiacephalosporins
US4148997A (en) * 1977-11-07 1979-04-10 Yeda Research And Development Co., Ltd. 7-[Sulfomethyl)phenyl]acetamidocephalosporin derivatives
US4124762A (en) * 1977-11-07 1978-11-07 Yeda Research And Development Co., Ltd. 7-[(Pyridylthiomethyl)phenyl]acetamido-cephalosporin derivatives
US4125715A (en) * 1977-11-25 1978-11-14 Yeda Research And Development Co. Ltd. 7-[(Substituted-isothioureamethyl)phenyl]-acetamidocephalosporin derivatives

Also Published As

Publication number Publication date
DE3061751D1 (en) 1983-03-03
IL59912A (en) 1984-02-29
GB2047707A (en) 1980-12-03
AR230450A1 (es) 1984-04-30
FR2455605B1 (ko) 1983-05-27
SU860705A3 (ru) 1981-08-30
IT1141935B (it) 1986-10-08
EG14719A (en) 1985-06-30
GR68202B (ko) 1981-11-10
PL223753A1 (ko) 1981-02-13
AU538283B2 (en) 1984-08-09
IE49775B1 (en) 1985-12-11
PL125579B1 (en) 1983-05-31
AT370108B (de) 1983-03-10
PT71140A (en) 1980-05-01
IT8021697A0 (it) 1980-04-29
MY8500601A (en) 1985-12-31
KR840000078B1 (ko) 1984-02-08
LU82411A1 (fr) 1980-07-31
HU184750B (en) 1984-10-29
ES491085A0 (es) 1981-05-16
JPH0118077B2 (ko) 1989-04-03
FR2455605A1 (fr) 1980-11-28
GB2047707B (en) 1983-05-18
CS226013B2 (en) 1984-03-19
ZA802475B (en) 1981-12-30
CH646434A5 (fr) 1984-11-30
DK177980A (da) 1980-11-02
ATA220980A (de) 1982-07-15
PH15596A (en) 1983-02-28
US4252953A (en) 1981-02-24
DD150352A5 (de) 1981-08-26
NZ193528A (en) 1982-03-23
EP0018811A1 (en) 1980-11-12
FI801345A (fi) 1980-11-02
IE800882L (en) 1980-11-01
BE882980A (fr) 1980-10-27
CA1138867A (en) 1983-01-04
BG34905A3 (en) 1983-12-15
AU5791480A (en) 1980-11-06
ES8105316A1 (es) 1981-05-16
EP0018811B1 (en) 1983-01-26
JPS55153788A (en) 1980-11-29
RO79684A (ro) 1982-08-17

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