KR20260019013A - 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터 - Google Patents

마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터

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Publication number
KR20260019013A
KR20260019013A KR1020267001828A KR20267001828A KR20260019013A KR 20260019013 A KR20260019013 A KR 20260019013A KR 1020267001828 A KR1020267001828 A KR 1020267001828A KR 20267001828 A KR20267001828 A KR 20267001828A KR 20260019013 A KR20260019013 A KR 20260019013A
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KR
South Korea
Prior art keywords
myoc
cys
raav
arg
aav
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020267001828A
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English (en)
Korean (ko)
Inventor
피터 퍼찬
에이브러햄 스카리아
제프리 아딘저
Original Assignee
젠자임 코포레이션
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Publication date
Application filed by 젠자임 코포레이션 filed Critical 젠자임 코포레이션
Priority claimed from PCT/US2015/050515 external-priority patent/WO2016044478A1/en
Publication of KR20260019013A publication Critical patent/KR20260019013A/ko
Pending legal-status Critical Current

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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K38/00—Medicinal preparations containing peptides
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KR1020267001828A 2014-09-16 2015-09-16 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터 Pending KR20260019013A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462051299P 2014-09-16 2014-09-16
US62/051,299 2014-09-16
PCT/US2015/050515 WO2016044478A1 (en) 2014-09-16 2015-09-16 Adeno-associated viral vectors for treating myocilin (myoc) glaucoma
KR1020237042363A KR102916865B1 (ko) 2014-09-16 2015-09-16 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020237042363A Division KR102916865B1 (ko) 2014-09-16 2015-09-16 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터

Publications (1)

Publication Number Publication Date
KR20260019013A true KR20260019013A (ko) 2026-02-09

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ID=58640637

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Application Number Title Priority Date Filing Date
KR1020267001828A Pending KR20260019013A (ko) 2014-09-16 2015-09-16 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터
KR1020177010012A Active KR102612871B1 (ko) 2014-09-16 2015-09-16 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터
KR1020237042363A Active KR102916865B1 (ko) 2014-09-16 2015-09-16 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020177010012A Active KR102612871B1 (ko) 2014-09-16 2015-09-16 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터
KR1020237042363A Active KR102916865B1 (ko) 2014-09-16 2015-09-16 마이오실린(myoc) 녹내장을 치료하기 위한 아데노-관련 바이러스 벡터

Country Status (13)

Country Link
US (1) US10821193B2 (cg-RX-API-DMAC7.html)
EP (1) EP3194601B1 (cg-RX-API-DMAC7.html)
JP (2) JP6673923B2 (cg-RX-API-DMAC7.html)
KR (3) KR20260019013A (cg-RX-API-DMAC7.html)
CN (2) CN116585492A (cg-RX-API-DMAC7.html)
AU (2) AU2015317756B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017005235B1 (cg-RX-API-DMAC7.html)
CA (2) CA3280614A1 (cg-RX-API-DMAC7.html)
IL (1) IL251178B (cg-RX-API-DMAC7.html)
MX (2) MX2017003426A (cg-RX-API-DMAC7.html)
RU (2) RU2718047C2 (cg-RX-API-DMAC7.html)
SG (3) SG10201913430VA (cg-RX-API-DMAC7.html)
ZA (1) ZA201701881B (cg-RX-API-DMAC7.html)

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IL251178B (en) 2014-09-16 2022-07-01 Genzyme Corp Adeno-associated viral vector for the treatment of glaucoma myocilin (myoc)
JP7287611B2 (ja) * 2018-02-07 2023-06-06 学校法人日本医科大学 改良型アデノ随伴ウイルスベクター
US20210030719A1 (en) * 2018-02-22 2021-02-04 University Of South Florida Grp94 inhibitors to treat steroid-induced ocular hypertensions and glaucomas
EP3930694A1 (en) 2019-02-28 2022-01-05 Regeneron Pharmaceuticals, Inc. Adeno-associated virus vectors for the delivery of therapeutics
EP4255457A4 (en) * 2020-12-03 2025-05-21 University of Massachusetts DEVELOPMENT OF NEW GENE THERAPEUTIC AGENTS FOR FIBRODYSPLASIA OSSIFICANS PROGRESSIVA
CN113032010B (zh) * 2021-03-12 2022-09-20 歌尔科技有限公司 命令的传输控制方法、终端及计算机可读存储介质
CA3224868A1 (en) * 2021-06-28 2023-01-05 Alnylam Pharmaceuticals, Inc. Compositions and methods for silencing myoc expression
AU2022408167A1 (en) 2021-12-08 2024-06-06 Regeneron Pharmaceuticals, Inc. Mutant myocilin disease model and uses thereof
WO2023114446A2 (en) * 2021-12-16 2023-06-22 Peter Koulen A machine learning-based framework using electroretinography for detecting early-stage glaucoma
CN117343152B (zh) * 2023-04-18 2024-06-04 上海本导基因技术有限公司 一种用于治疗青光眼疾病的慢病毒样颗粒
CN118546217B (zh) * 2024-07-25 2024-10-29 广州译码基因科技有限公司 靶向小梁网、角膜缘及rpe的aav衣壳蛋白及其应用
CN121449764B (zh) * 2026-01-07 2026-05-19 山东伯桢生物科技有限公司 抑制Wnt信号通路的融合蛋白及其应用

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GB0403600D0 (en) * 2004-02-18 2004-03-24 Trinity College Dublin Methods and reagents for treating disease
WO2005117938A2 (en) 2004-04-13 2005-12-15 Regents Of The University Of Minnesota Methods of treating ocular conditions
WO2008075796A1 (ja) 2006-12-21 2008-06-26 Kyowa Hakko Kirin Co., Ltd. 血球回復促進剤
AU2008308784B2 (en) * 2007-10-01 2013-07-18 Arrowhead Research Corporation Self complementary AAV-mediated delivery of interfering RNA molecules to treat or prevent ocular disorders
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DK3693025T3 (da) * 2011-04-22 2022-01-10 Univ California Adenoassocierede virus-virioner med variant capsid og fremgangsmåder til anvendelse heraf
EP2554662A1 (en) * 2011-08-05 2013-02-06 M Maria Pia Cosma Methods of treatment of retinal degeneration diseases
BR112014019741A2 (pt) * 2012-02-11 2020-12-22 Genentech, Inc Usos de um antagonista da via wnt, uso de uma terapia anticâncer, método de identificação de um indivíduo com câncer, métodos para prever, método de inibição da proliferação de uma célula de câncer, uso de um antagonista da translocação de r-spondina e antagonista da translocação de r-spondina isolado
EP3470523A1 (en) * 2012-05-09 2019-04-17 Oregon Health & Science University Adeno associated virus plasmids and vectors
IL251178B (en) 2014-09-16 2022-07-01 Genzyme Corp Adeno-associated viral vector for the treatment of glaucoma myocilin (myoc)

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US20170304465A1 (en) 2017-10-26
BR112017005235A2 (pt) 2017-12-12
SG10201902285SA (en) 2019-04-29
IL251178A0 (en) 2017-05-29
CA3280614A1 (en) 2026-03-02
RU2746991C2 (ru) 2021-04-23
RU2017112972A (ru) 2018-10-17
JP2017529395A (ja) 2017-10-05
RU2020111038A3 (cg-RX-API-DMAC7.html) 2020-10-15
EP3194601A1 (en) 2017-07-26
AU2015317756A1 (en) 2017-04-13
ZA201701881B (en) 2023-09-27
KR20170054493A (ko) 2017-05-17
JP6673923B2 (ja) 2020-03-25
JP7097398B2 (ja) 2022-07-07
CN116585492A (zh) 2023-08-15
SG11201702055PA (en) 2017-04-27
CN107001436A (zh) 2017-08-01
CA2961523C (en) 2026-01-13
AU2022202413A1 (en) 2022-05-05
KR102916865B1 (ko) 2026-01-23
KR20230172610A (ko) 2023-12-22
KR102612871B1 (ko) 2023-12-13
MX2023005998A (es) 2023-06-08
RU2017112972A3 (cg-RX-API-DMAC7.html) 2019-04-16
IL251178B (en) 2022-07-01
BR112017005235B1 (pt) 2023-10-31
RU2718047C2 (ru) 2020-03-30
JP2020105194A (ja) 2020-07-09
EP3194601B1 (en) 2021-10-27
CA2961523A1 (en) 2016-03-24
AU2015317756B2 (en) 2022-01-13
RU2020111038A (ru) 2020-04-29
CN107001436B (zh) 2023-01-06
SG10201913430VA (en) 2020-03-30
MX2017003426A (es) 2017-07-28
US10821193B2 (en) 2020-11-03

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