KR20250105683A - 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법 - Google Patents

덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법 Download PDF

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Publication number
KR20250105683A
KR20250105683A KR1020257021141A KR20257021141A KR20250105683A KR 20250105683 A KR20250105683 A KR 20250105683A KR 1020257021141 A KR1020257021141 A KR 1020257021141A KR 20257021141 A KR20257021141 A KR 20257021141A KR 20250105683 A KR20250105683 A KR 20250105683A
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KR
South Korea
Prior art keywords
subject
dexmedetomidine
delivery device
transdermal delivery
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257021141A
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English (en)
Korean (ko)
Inventor
로즈 마리 곤살베스
주타로 슈도
완-닝 송
스티븐 쉬핑 황
Original Assignee
테이코쿠 팔마 유에스에이, 인코포레이티드
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Publication of KR20250105683A publication Critical patent/KR20250105683A/ko
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020257021141A 2016-10-31 2017-10-31 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법 Pending KR20250105683A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662415248P 2016-10-31 2016-10-31
US62/415,248 2016-10-31
US201762547582P 2017-08-18 2017-08-18
US62/547,582 2017-08-18
PCT/US2017/059357 WO2018081812A2 (en) 2016-10-31 2017-10-31 Methods of managing pain using dexmedetomidine transdermal delivery devices
KR1020237010276A KR20230048156A (ko) 2016-10-31 2017-10-31 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020237010276A Division KR20230048156A (ko) 2016-10-31 2017-10-31 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법

Publications (1)

Publication Number Publication Date
KR20250105683A true KR20250105683A (ko) 2025-07-08

Family

ID=62020311

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020237010276A Ceased KR20230048156A (ko) 2016-10-31 2017-10-31 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법
KR1020217028734A Ceased KR20210113439A (ko) 2016-10-31 2017-10-31 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법
KR1020257021141A Pending KR20250105683A (ko) 2016-10-31 2017-10-31 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법
KR1020197014883A Ceased KR20190060007A (ko) 2016-10-31 2017-10-31 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법

Family Applications Before (2)

Application Number Title Priority Date Filing Date
KR1020237010276A Ceased KR20230048156A (ko) 2016-10-31 2017-10-31 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법
KR1020217028734A Ceased KR20210113439A (ko) 2016-10-31 2017-10-31 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020197014883A Ceased KR20190060007A (ko) 2016-10-31 2017-10-31 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법

Country Status (10)

Country Link
US (1) US20180117012A1 (enExample)
EP (1) EP3532038A4 (enExample)
JP (3) JP2019534288A (enExample)
KR (4) KR20230048156A (enExample)
CN (1) CN110022865A (enExample)
BR (1) BR112019006955A2 (enExample)
CA (1) CA3038354C (enExample)
RU (1) RU2723761C1 (enExample)
TW (1) TWI764951B (enExample)
WO (1) WO2018081812A2 (enExample)

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CA3038354C (en) * 2016-10-31 2021-08-17 Teikoku Pharma Usa, Inc. Methods of managing pain using dexmedetomidine transdermal delivery devices
CN110087640A (zh) 2016-12-20 2019-08-02 罗曼治疗系统股份公司 包含阿塞那平的透皮治疗系统
US11337932B2 (en) 2016-12-20 2022-05-24 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
EP3562486B1 (en) 2016-12-31 2024-03-13 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
US12329862B2 (en) * 2018-06-20 2025-06-17 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
EP3813802B1 (en) 2018-06-27 2024-10-23 Bioxcel Therapeutics, Inc. Film formulations containing dexmedetomidine and methods of producing them
KR20210153667A (ko) * 2019-04-17 2021-12-17 에르테에스 로만 테라피-시스테메 아게 경피 치료 시스템
AU2020316013A1 (en) 2019-07-19 2022-02-17 Arx, Llc Non-sedating dexmedetomidine treatment regimens
WO2021026378A1 (en) * 2019-08-07 2021-02-11 Alkermes, Inc. Indole compounds for the treatment of pain
WO2021026375A1 (en) * 2019-08-07 2021-02-11 Alkermes, Inc. Fused bicyclic compounds for the treatment of pain
WO2021026377A1 (en) * 2019-08-07 2021-02-11 Alkermes, Inc. Lactam-containing compounds for the treatment of pain
WO2021026380A1 (en) * 2019-08-07 2021-02-11 Alkermes, Inc. Phenyltriazole compounds for the treatment of pain
CN111281850A (zh) * 2020-03-14 2020-06-16 周琛 止痛药物组合物及其用途
CN116098876A (zh) * 2021-11-11 2023-05-12 北京泰德制药股份有限公司 一种右美托咪定透皮贴剂及其制备方法和应用
WO2024037545A1 (zh) * 2022-08-17 2024-02-22 宜昌人福药业有限责任公司 右美托咪定经皮组合物、透皮贴剂及其制备方法和应用
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
TW202519210A (zh) * 2023-09-05 2025-05-16 美商帝國製藥美國有限公司 用於治療疼痛之經皮遞送貼片

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KR20180095732A (ko) * 2013-10-07 2018-08-27 테이코쿠 팔마 유에스에이, 인코포레이티드 비진정량의 덱스메데토미딘의 경피 전달을 위한 방법 및 조성물
ES2983565T3 (es) * 2013-10-07 2024-10-23 Teikoku Pharma Usa Inc Métodos y composiciones para tratar los síndromes de abstinencia mediante el uso de composiciones transdérmicas de dexmedetomidina no sedantes
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CA3038354C (en) * 2016-10-31 2021-08-17 Teikoku Pharma Usa, Inc. Methods of managing pain using dexmedetomidine transdermal delivery devices

Also Published As

Publication number Publication date
KR20210113439A (ko) 2021-09-15
WO2018081812A2 (en) 2018-05-03
CA3038354A1 (en) 2018-05-03
CA3038354C (en) 2021-08-17
KR20230048156A (ko) 2023-04-10
TWI764951B (zh) 2022-05-21
EP3532038A2 (en) 2019-09-04
KR20190060007A (ko) 2019-05-31
CN110022865A (zh) 2019-07-16
JP2019534288A (ja) 2019-11-28
RU2723761C1 (ru) 2020-06-17
EP3532038A4 (en) 2020-06-03
TW201817419A (zh) 2018-05-16
BR112019006955A2 (pt) 2019-07-02
JP2023036825A (ja) 2023-03-14
WO2018081812A3 (en) 2019-01-17
JP2025108704A (ja) 2025-07-23
US20180117012A1 (en) 2018-05-03

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