JP2019534288A - デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法 - Google Patents

デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法 Download PDF

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Publication number
JP2019534288A
JP2019534288A JP2019522825A JP2019522825A JP2019534288A JP 2019534288 A JP2019534288 A JP 2019534288A JP 2019522825 A JP2019522825 A JP 2019522825A JP 2019522825 A JP2019522825 A JP 2019522825A JP 2019534288 A JP2019534288 A JP 2019534288A
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JP
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Prior art keywords
subject
dexmedetomidine
hours
delivery device
transdermal delivery
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2019522825A
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English (en)
Japanese (ja)
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JP2019534288A5 (enExample
Inventor
ゴンソルブス，ローズ・マリー
十太郎 首藤
十太郎 首藤
ソン，ワン−ニン
ファン，スティーヴン・シッピング
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Teikoku Pharma USA Inc
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Teikoku Pharma USA Inc
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Filing date
Publication date
Application filed by Teikoku Pharma USA Inc filed Critical Teikoku Pharma USA Inc
Publication of JP2019534288A publication Critical patent/JP2019534288A/ja
Publication of JP2019534288A5 publication Critical patent/JP2019534288A5/ja
Priority to JP2022206760A priority Critical patent/JP2023036825A/ja
Priority to JP2025071090A priority patent/JP2025108704A/ja
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019522825A 2016-10-31 2017-10-31 デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法 Withdrawn JP2019534288A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022206760A JP2023036825A (ja) 2016-10-31 2022-12-23 デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法
JP2025071090A JP2025108704A (ja) 2016-10-31 2025-04-23 デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662415248P 2016-10-31 2016-10-31
US62/415,248 2016-10-31
US201762547582P 2017-08-18 2017-08-18
US62/547,582 2017-08-18
PCT/US2017/059357 WO2018081812A2 (en) 2016-10-31 2017-10-31 Methods of managing pain using dexmedetomidine transdermal delivery devices

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022206760A Division JP2023036825A (ja) 2016-10-31 2022-12-23 デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法

Publications (2)

Publication Number Publication Date
JP2019534288A true JP2019534288A (ja) 2019-11-28
JP2019534288A5 JP2019534288A5 (enExample) 2020-04-23

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JP2019522825A Withdrawn JP2019534288A (ja) 2016-10-31 2017-10-31 デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法
JP2022206760A Withdrawn JP2023036825A (ja) 2016-10-31 2022-12-23 デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法
JP2025071090A Pending JP2025108704A (ja) 2016-10-31 2025-04-23 デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法

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JP2022206760A Withdrawn JP2023036825A (ja) 2016-10-31 2022-12-23 デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法
JP2025071090A Pending JP2025108704A (ja) 2016-10-31 2025-04-23 デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法

Country Status (10)

Country Link
US (1) US20180117012A1 (enExample)
EP (1) EP3532038A4 (enExample)
JP (3) JP2019534288A (enExample)
KR (4) KR20210113439A (enExample)
CN (1) CN110022865A (enExample)
BR (1) BR112019006955A2 (enExample)
CA (1) CA3038354C (enExample)
RU (1) RU2723761C1 (enExample)
TW (1) TWI764951B (enExample)
WO (1) WO2018081812A2 (enExample)

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JP2023036825A (ja) * 2016-10-31 2023-03-14 テイコク ファーマ ユーエスエー インコーポレーテッド デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法

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CN110087641B (zh) 2016-12-20 2024-03-12 罗曼治疗系统股份公司 含有阿塞那平和聚硅氧烷或聚异丁烯的透皮治疗系统
KR102506333B1 (ko) 2016-12-20 2023-03-06 에르테에스 로만 테라피-시스테메 아게 아세나핀을 함유하는 경피흡수 치료 시스템
CA3045043A1 (en) 2016-12-31 2018-07-05 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
CN112533593A (zh) * 2018-06-20 2021-03-19 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
CN115154440A (zh) 2018-06-27 2022-10-11 比奥克斯塞尔医疗股份有限公司 含右美托咪定的膜制剂及其制造方法
JP7453994B2 (ja) * 2019-04-17 2024-03-21 エルテーエス ローマン テラピー－ジステーメ アーゲー 経皮治療システム
WO2021016112A2 (en) 2019-07-19 2021-01-28 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
WO2021026377A1 (en) * 2019-08-07 2021-02-11 Alkermes, Inc. Lactam-containing compounds for the treatment of pain
WO2021026378A1 (en) * 2019-08-07 2021-02-11 Alkermes, Inc. Indole compounds for the treatment of pain
WO2021026375A1 (en) * 2019-08-07 2021-02-11 Alkermes, Inc. Fused bicyclic compounds for the treatment of pain
WO2021026380A1 (en) * 2019-08-07 2021-02-11 Alkermes, Inc. Phenyltriazole compounds for the treatment of pain
CN111281850A (zh) * 2020-03-14 2020-06-16 周琛 止痛药物组合物及其用途
CN116098876A (zh) * 2021-11-11 2023-05-12 北京泰德制药股份有限公司 一种右美托咪定透皮贴剂及其制备方法和应用
WO2024037545A1 (zh) * 2022-08-17 2024-02-22 宜昌人福药业有限责任公司 右美托咪定经皮组合物、透皮贴剂及其制备方法和应用
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
US20250099399A1 (en) * 2023-09-05 2025-03-27 Teikoku Pharma Usa, Inc. Transdermal delivery patch for treating pain

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JPH01294623A (ja) * 1988-02-29 1989-11-28 Farmos Yhtymae Oy ４‐置換イミダゾール誘導体を有効成分とする手術に際して使用する薬剤
JPH05503916A (ja) * 1989-08-18 1993-06-24 シグナス，インコーポレイテッド デキスメデトミジンを経皮的に投与する方法およびデバイス
JP2011524345A (ja) * 2008-06-04 2011-09-01 コーダ セラピューティクス， インコーポレイテッド ギャップジャンクション調節化合物を用いる疼痛の治療
JP2013516482A (ja) * 2010-01-08 2013-05-13 レクロ・ファーマ，インコーポレーテッド 局所経皮用デクスメデトミジン組成物およびそれらの使用方法
JP2014528474A (ja) * 2011-10-14 2014-10-27 ホスピーラ インコーポレイテッド デクスメデトミジンを用いて小児患者を治療する方法
WO2015093503A1 (ja) * 2013-12-18 2015-06-25 丸石製薬株式会社 含水型貼付剤
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JP2013516482A (ja) * 2010-01-08 2013-05-13 レクロ・ファーマ，インコーポレーテッド 局所経皮用デクスメデトミジン組成物およびそれらの使用方法
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023036825A (ja) * 2016-10-31 2023-03-14 テイコク ファーマ ユーエスエー インコーポレーテッド デクスメデトミジン経皮送達デバイスを用いた疼痛管理の方法

Also Published As

Publication number Publication date
KR20250105683A (ko) 2025-07-08
TW201817419A (zh) 2018-05-16
KR20230048156A (ko) 2023-04-10
CN110022865A (zh) 2019-07-16
EP3532038A4 (en) 2020-06-03
WO2018081812A2 (en) 2018-05-03
BR112019006955A2 (pt) 2019-07-02
US20180117012A1 (en) 2018-05-03
CA3038354A1 (en) 2018-05-03
TWI764951B (zh) 2022-05-21
RU2723761C1 (ru) 2020-06-17
JP2025108704A (ja) 2025-07-23
KR20190060007A (ko) 2019-05-31
JP2023036825A (ja) 2023-03-14
KR20210113439A (ko) 2021-09-15
WO2018081812A3 (en) 2019-01-17
CA3038354C (en) 2021-08-17
EP3532038A2 (en) 2019-09-04

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