KR20250078595A - 조절된 난소 자극용 조성물 - Google Patents
조절된 난소 자극용 조성물 Download PDFInfo
- Publication number
- KR20250078595A KR20250078595A KR1020257016376A KR20257016376A KR20250078595A KR 20250078595 A KR20250078595 A KR 20250078595A KR 1020257016376 A KR1020257016376 A KR 1020257016376A KR 20257016376 A KR20257016376 A KR 20257016376A KR 20250078595 A KR20250078595 A KR 20250078595A
- Authority
- KR
- South Korea
- Prior art keywords
- amh
- pmol
- body weight
- patient
- fsh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pregnancy & Childbirth (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17189119 | 2017-09-01 | ||
| EP17189119.5 | 2017-09-01 | ||
| PCT/EP2018/073442 WO2019043143A1 (en) | 2017-09-01 | 2018-08-31 | COMPOSITION FOR CONTROLLED OVARIAN STIMULATION |
| KR1020207009105A KR20200045543A (ko) | 2017-09-01 | 2018-08-31 | 조절된 난소 자극용 조성물 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207009105A Division KR20200045543A (ko) | 2017-09-01 | 2018-08-31 | 조절된 난소 자극용 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20250078595A true KR20250078595A (ko) | 2025-06-02 |
Family
ID=59772482
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257016376A Pending KR20250078595A (ko) | 2017-09-01 | 2018-08-31 | 조절된 난소 자극용 조성물 |
| KR1020207009105A Ceased KR20200045543A (ko) | 2017-09-01 | 2018-08-31 | 조절된 난소 자극용 조성물 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207009105A Ceased KR20200045543A (ko) | 2017-09-01 | 2018-08-31 | 조절된 난소 자극용 조성물 |
Country Status (32)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI846743B (zh) | 2018-10-17 | 2024-07-01 | 荷蘭商菲林公司 | 用於控制性卵巢刺激之組成物及方法 |
| TW202237173A (zh) * | 2020-12-09 | 2022-10-01 | 荷蘭商菲林公司 | 用於受控的卵巢刺激之組成物及方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE267608T1 (de) * | 2000-01-27 | 2004-06-15 | Applied Research Systems | Verwendung von fsh zur behandlung von infertilität |
| US20040248784A1 (en) | 2003-06-03 | 2004-12-09 | Marco Filicori | Unitary combinations of FSH and hCG |
| CA2700335C (en) * | 2007-09-21 | 2015-12-01 | Pharmabrand S.A. | Composition comprising mucilaginous polysaccharides derived from aloe barbadensis combined with liposomes, method for obtaining same and use thereof as a sun protector, an anti-acne agent, an epidermal regenerator and a moisturiser |
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| WO2011089602A2 (en) * | 2010-01-21 | 2011-07-28 | Ramot At Tel-Aviv University Ltd. | Aloe-emodin derivatives and use thereof for the treatment of cancer |
| RS54214B2 (sr) | 2010-09-29 | 2024-02-29 | Ferring Bv | Smeša za upotrebu u lečenju infertiliteta |
| EP2717904A1 (en) | 2011-06-06 | 2014-04-16 | Ferring BV | Pharmaceutical preparation comprising recombinant fsh |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| CA2945883A1 (en) * | 2014-04-18 | 2015-10-22 | Glycotope Gmbh | Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone |
| MD3261661T2 (ro) | 2015-02-26 | 2024-04-30 | Ferring Bv | Menotropină pentru tratarea infertilității |
| HUE048757T2 (hu) * | 2015-04-17 | 2020-08-28 | Ferring Bv | FSH meddõség kezelésére |
| EP3286209B1 (en) | 2015-04-24 | 2020-11-25 | Ferring BV | Method of production of gonadotrophin |
| AU2016282916B2 (en) | 2015-06-26 | 2022-01-20 | Ferring B.V. | Methods of purification and/or viral inactivation |
| PL3787667T3 (pl) | 2018-04-30 | 2025-07-28 | Ferring B.V. | Kompozycja do kontrolowanej stymulacji jajników |
| TWI846743B (zh) | 2018-10-17 | 2024-07-01 | 荷蘭商菲林公司 | 用於控制性卵巢刺激之組成物及方法 |
-
2018
- 2018-08-31 MA MA50034A patent/MA50034B1/fr unknown
- 2018-08-31 KR KR1020257016376A patent/KR20250078595A/ko active Pending
- 2018-08-31 LT LTEP21196378.0T patent/LT3973982T/lt unknown
- 2018-08-31 DK DK18768795.9T patent/DK3675894T3/da active
- 2018-08-31 MX MX2020002235A patent/MX2020002235A/es unknown
- 2018-08-31 CN CN202510833422.5A patent/CN120617484A/zh active Pending
- 2018-08-31 AR ARP180102492 patent/AR112541A1/es unknown
- 2018-08-31 ES ES18768795T patent/ES2904787T3/es active Active
- 2018-08-31 MA MA56224A patent/MA56224B1/fr unknown
- 2018-08-31 TW TW107130683A patent/TWI749255B/zh active
- 2018-08-31 WO PCT/EP2018/073442 patent/WO2019043143A1/en not_active Ceased
- 2018-08-31 JP JP2020512546A patent/JP6856819B2/ja active Active
- 2018-08-31 HR HRP20211802TT patent/HRP20211802T1/hr unknown
- 2018-08-31 EA EA202090480A patent/EA202090480A1/ru unknown
- 2018-08-31 JO JOP/2020/0034A patent/JOP20200034A1/ar unknown
- 2018-08-31 EP EP21196378.0A patent/EP3973982B1/en active Active
- 2018-08-31 KR KR1020207009105A patent/KR20200045543A/ko not_active Ceased
- 2018-08-31 RS RS20220042A patent/RS62810B1/sr unknown
- 2018-08-31 CA CA3073624A patent/CA3073624A1/en active Pending
- 2018-08-31 IL IL272763A patent/IL272763B2/en unknown
- 2018-08-31 EP EP18768795.9A patent/EP3675894B1/en active Active
- 2018-08-31 BR BR112020003379-0A patent/BR112020003379A2/pt unknown
- 2018-08-31 PT PT187687959T patent/PT3675894T/pt unknown
- 2018-08-31 HU HUE21196378A patent/HUE068024T2/hu unknown
- 2018-08-31 HU HUE18768795A patent/HUE056726T2/hu unknown
- 2018-08-31 DK DK21196378.0T patent/DK3973982T3/da active
- 2018-08-31 RS RS20241007A patent/RS65945B1/sr unknown
- 2018-08-31 AU AU2018326556A patent/AU2018326556B2/en active Active
- 2018-08-31 FI FIEP21196378.0T patent/FI3973982T3/fi active
- 2018-08-31 UA UAA202002175A patent/UA126869C2/uk unknown
- 2018-08-31 EP EP24181981.2A patent/EP4427806A3/en active Pending
- 2018-08-31 PT PT211963780T patent/PT3973982T/pt unknown
- 2018-08-31 PL PL21196378.0T patent/PL3973982T3/pl unknown
- 2018-08-31 MY MYPI2020000971A patent/MY200791A/en unknown
- 2018-08-31 MD MDE20220351T patent/MD3973982T2/ro unknown
- 2018-08-31 SI SI201831147T patent/SI3973982T1/sl unknown
- 2018-08-31 ES ES21196378T patent/ES2989511T3/es active Active
- 2018-08-31 CN CN201880055934.1A patent/CN111050787A/zh active Pending
- 2018-08-31 SG SG11202003840QA patent/SG11202003840QA/en unknown
- 2018-08-31 US US16/642,777 patent/US11744879B2/en active Active
- 2018-08-31 HR HRP20241171TT patent/HRP20241171T1/hr unknown
- 2018-08-31 SI SI201830484T patent/SI3675894T1/sl unknown
- 2018-08-31 PL PL18768795T patent/PL3675894T3/pl unknown
- 2018-08-31 MD MDE20200700T patent/MD3675894T2/ro unknown
- 2018-08-31 LT LTEPPCT/EP2018/073442T patent/LT3675894T/lt unknown
-
2020
- 2020-02-27 MX MX2024009224A patent/MX2024009224A/es unknown
- 2020-02-27 CL CL2020000482A patent/CL2020000482A1/es unknown
- 2020-02-28 PH PH12020500404A patent/PH12020500404A1/en unknown
- 2020-10-30 JP JP2020182295A patent/JP7373479B2/ja active Active
-
2023
- 2023-07-25 US US18/226,206 patent/US20240024424A1/en active Pending
Non-Patent Citations (47)
| Title |
|---|
| Andersen CY, Westergaard LG, and van Wely M. (2004). FSH isoform composition of commercial gonadotrophin preparations: a neglected aspect? Reprod Biomed Online. 9(2), 231-236. |
| Arey BJ, Stevis PE, Deecher DC, Shen ES, Frail DE, Negro-Vilar A, and Lopez FJ. (1997) Induction of promiscuous G protein coupling of the follicle-stimulating hormone (FSH) receptor: a novel mechanism for transducing pleiotropic actions of FSH isoforms. Mol Endocrinol. 11(5), 517-526. |
| Baenziger JU and Green ED. (1988). Pituitary glycoprotein hormone oligosaccharides: structure, synthesis and function of the asparagine-linked oligosaccharides on lutropin, follitropin and thyrotropin. Biochim Biophys Acta. 947(2), 287-306. |
| Bassett RM, and Driebergen R. (2005). Continued improvements in the quality and consistency of follitropin alfa, recombinant human FSH. Reprod Biomed Online. 10(2), 169-177. |
| Dalpathado DS, Irungu J, Go EP, Butnev VY, Norton K, Bousfield GR, and Desaire H. (2006). Comparative glycomics of the glycoprotein follicle stimulating hormone: glycopeptide analysis of isolates from two mammalian species. Biochemistry. 45(28), 8665-8673. |
| Damian-Matsumura P, Zaga V, Maldonado A, Sanchez-Hernandez C, Timossi C, and Ulloa-Aguirre A. (1999). Oestrogens regulate pituitary alpha2,3-sialyltransferase messenger ribonucleic acid levels in the female rat. J Mol Endocrinol. 23(2), 153-165. |
| D'Antonio M., Borrelli F. , Datola A., Bucci R. , Mascia M. , Polletta P., Piscitelli D., and Papoian R. (1999) Biological characterization of recombinant human follicle stimulating hormone isoforms. Human Reproduction 14, 1160-1167. |
| de Leeuw, R., Mulders, J., Voortman, G. Rombout, F. Damm, J. and Kloosterboer, L. (1996) Structure-function relationship of recombinant follicle stimulating hormone (Puregon). Mol. Hum. Reprod., 2, 361-369. |
| Dias JA, Van Roey P. (2001). Structural biology of human follitropin and its receptor. Arch Med Res. 32(6), 510-519. |
| Fiddes, J. C. and Goodman, H. M. (1979) Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin. Nature, 281, 351-356. |
| Flack, M.R., Bennet, A.P., Froehlich, J. Anasti, JN and Nisula, B. (1994). Increased biological activity due to basic isoforms in recombinant human follicle-stimulating hormone produced in a human cell line. J. Clin. Endocrinol. Metab., 79, 756-760. |
| Fox KM, Dias JA, and Van Roey P. (2001). Three-dimensional structure of human follicle-stimulating hormone. Mol Endocrinol. 15(3), 378-89. |
| Grabenhorst E, Hoffmann A, Nimtz M, Zettlmeissl G, and Conradt HS. (1995). Construction of stable BHK-21 cells coexpressing human secretory glycoproteins and human Gal(beta 1-4)GlcNAc-R alpha 2,6-sialyltransferase alpha 2,6-linked NeuAc is preferentially attached to the Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)-branch of diantennary oligosaccharides from secreted recombinant beta-trace protein. Eur J Biochem. 232(3), 718-25. |
| Green ED and Baenziger JU. (1988). Asparagine-linked oligosaccharides on lutropin, follitropin, and thyrotropin. II. Distributions of sulfated and sialylated oligosaccharides on bovine, ovine, and human pituitary glycoprotein hormones. J Biol Chem. 263(1), 36-44. |
| Grundmann,U., Nerlich,C., Rein,T. and Zettlmeissl, G. (1990). Complete cDNA sequence encoding human beta-galactoside alpha-2,6-sialyltransferase. G Nucleic Acids Res. 18 (3), 667 |
| Howles, C.M. (1996). Genetic engineering of human FSH (Gonal-F). Hum Reprod. Update, 2,172-191. |
| Kagawa Y, Takasaki S, Utsumi J, Hosoi K, Shimizu H, Kochibe N, and Kobata A. (1988). Comparative study of the asparagine-linked sugar chains of natural human interferon-beta 1 and recombinant human interferon-beta 1 produced by three different mammalian cells. J Biol Chem. 263(33), 17508-17515. |
| Keene, J.L., Matzuk, M.M., Otani, T., Fauser, B,C,J,M., Galway, A.B., Hsueh, A.J.W. and Boime, I. (1989). Expression of Biologically active Human Follitropin in Chinese Hamster Ovary Cells. The Journal of Biological Chemistry, 264(9), 4769-4775. |
| Kitagawa,H. and Paulson,J.C (1994) Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups. J. Biol. Chem. 269(2), 1394-1401. |
| Lee EU, Roth J, and Paulson JC (1989) Alteration of terminal glycosylation sequences on N-linked oligosaccharides of Chinese hamster ovary cells by expression of beta-galactoside alpha 2,6-sialyltransferase. J Biol Chem. 264(23), 13848-13855. |
| Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951) Protein measurement with the Folin phenol reagent. J Biol Chem. 193(1), 265-75. |
| Lowry, PJ, McLean, C, Jones RL and Satgunasingam N. (1976) Purification of anterior pituitary and hypothalamic hormones Clin Pathol Suppl (Assoc Clin Pathol). 7, 16-21. |
| Olivennes F, Howles CM, Borini A, Germond M, Trew G, Wikland M, Zegers-Hochschild F, Saunders H (2009) Individualizing FSH dose for assisted reproduction using a novel algorithm: the CONSORT study. Reprod Biomed Online. 2009 Feb;18(2):195-204. |
| Pierce JG, and Parsons TF (1981) Glycoprotein hormones: structure and function Annu Rev Biochem. 50, 465-495. |
| Pricer WE Jr, and Ashwell G. (1971). The binding of desialylated glycoproteins by plasma membranes of rat liver. J Biol Chem. 246(15), 4825-33. |
| Rathnam P, and Saxena BB. (1975). Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit. J Biol Chem.;250(17):6735-6746. |
| Regoeczi E, Debanne MT, Hatton MC, and Koj A. (1978) Elimination of asialofetuin and asialoorosomucoid by the intact rat. Quantitative aspects of the hepatic clearance mechanism. Biochim Biophys Acta. 541(3), 372-84. |
| Royle L, Radcliffe CM, Dwek RA and Rudd PM (2006) Methods in Molecular Biology, ed I Brockhausen-Schutzbach (Humana Press), 347: Glycobiology protocols, 125-144. |
| Ryan RJ, Keutmann HT, Charlesworth MC, McCormick DJ, Milius RP, Calvo FO and Vutyavanich T. (1987). Structure-function relationships of gonadotropins. Recent Prog Horm Res.;43,:383-429. |
| Saxena BB and Rathnam P. (1976) Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands. J Biol Chem. 251(4), 993-1005. |
| Steelman SL, and Pohley FM. (1953) Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotropin. Endocrinology. 53(6), 604-616. |
| Steer CJ, and Ashwell G. (1980) Studies on a mammalian hepatic binding protein specific for asialoglycoproteins. Evidence for receptor recycling in isolated rat hepatocytes. J Biol Chem. 255(7), 3008-13. |
| Svensson EC, Soreghan B, and Paulson JC. (1990) Organization of the beta-galactoside alpha 2,6-sialyltransferase gene. Evidence for the transcriptional regulation of terminal glycosylation. J Biol Chem. 265(34):20863-20868. |
| Takeuchi M, Takasaki S, Miyazaki H, Kato T, Hoshi S, Kochibe N, and Kobata A (1988). Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells. J Biol Chem. 263(8), 3657-3663. |
| Timossi CM, Barrios de Tomasi J, Zambrano E, Gonzalez R, Ulloa-Aguirre A. (1998). A naturally occurring basically charged human follicle-stimulating hormone (FSH) variant inhibits FSH-induced androgen aromatization and tissue-type plasminogen activator enzyme activity in vitro. Neuroendocrinology. 67(3), 153-163. |
| Timossi CM, Barrios-de-Tomasi J, Gonzalez-Suarez R, Arranz MC, Padmanabhan V, Conn PM, and Ulloa-Aguirre A. (2000). Differential effects of the charge variants of human follicle-stimulating hormone. J Endocrinol. 165(2), 193-205. |
| Ulloa-Aguirre A, Maldonado A, Damian-Matsumura P, and Timossi C (2001). Endocrine regulation of gonadotropin glycosylation. Arch Med Res. 32(6), 520-532. |
| Ulloa-Aguirre A, Midgley AR Jr, Beitins IZ, and Padmanabhan V. (1995). Follicle-stimulating isohormones: characterization and physiological relevance. Endocr Rev.16(6), 765-787. |
| Ulloa-Aguirre A, Timossi C, Barrios-de-Tomasi J, Maldonado A, and Nayudu P. (2003). Impact of carbohydrate heterogeneity in function of follicle-stimulating hormone: studies derived from in vitro and in vivo models. Biol Reprod. 69(2), 379-389. |
| Ulloa-Aguirre, A., Cravioto, A., Damian-Matsumura, P. Jimenez, M, Zambrano, E and Diaz-Sanchez, V. (1992) Biological characterization of the naturally occurring analogues of intrapituitary human follicle stimulating hormone. Hum. Reprod. 7, 23-30. |
| Ulloa-Aguirre, A., Espinoza, R., Damian-Matsumura, P. and Chappel, S.C. (1988) Immunological and biological potencies of the different molecular species of gonadotrophins. Hum. Reprod. 3, 491-501. |
| Van Lenten L, and Ashwell G. (1972) The binding of desialylated glycoproteins by plasma membranes of rat liver. Development of a quantitative inhibition assay. J Biol Chem. 247(14), 4633-40. |
| Wide L, Naessen T, Sundstrom-Poromaa I, Eriksson K. (2007) Sulfonation and sialylation of gonadotropins in women during the menstrual cycle, after menopause, and with polycystic ovarian syndrome and in men. J Clin Endocrinol Metab.;92(11), 4410-4417. |
| Wide, L. and Albertsson-Wikland, K. (1990) Change in electrophoretic mobility of human follicle-stimulating hormone in serum after administration of gonadotropin-releasing hormone. J. Clin. Endocrinol. Metab. 70, 271-276. |
| Wide, L. and Bakos, O. (1993). More basic forms of both human follicle-stimulating hormone and luteinizing hormone in serum at midcycle compared with the follicular or luteal phase. J. Clin. Endocrinol. Metab., 76, 885-889. |
| Zambrano E, Zarinan T, Olivares A, Barrios-de-Tomasi J, and Ulloa-Aguirre A. (1999). Receptor binding activity and in vitro biological activity of the human FSH charge isoforms as disclosed by heterologous and homologous assay systems: implications for the structure-function relationship of the FSH variants. Endocrine. 10(2), 113-121. |
| Zhang X, Lok SH, and Kon OL (1998) Stable expression of human alpha-2,6-sialyltransferase in Chinese hamster ovary cells: functional consequences for human erythropoietin expression and bioactivity. Biochim Biophys Acta. 1425(3), 441-452. |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3787667B1 (en) | Composition for controlled ovarian stimulation | |
| US20240024424A1 (en) | Composition for controlled ovarian stimulation | |
| US20250325637A1 (en) | Compositions and methods for controlled ovarian stimulation | |
| HK40115814A (en) | Composition for controlled ovarian stimulation | |
| HK40066975B (en) | Composition for controlled ovarian stimulation | |
| HK40066975A (en) | Composition for controlled ovarian stimulation | |
| HK40021791B (en) | Composition for controlled ovarian stimulation | |
| EA046202B1 (ru) | Композиция для контролируемой стимуляции яичников | |
| HK40055068A (en) | Compositions comprising a recombinant fsh for the treatment of infertility | |
| HK40055068B (en) | Compositions comprising a recombinant fsh for the treatment of infertility | |
| HK40041223B (en) | Composition for controlled ovarian stimulation | |
| HK40041223A (en) | Composition for controlled ovarian stimulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| PA0104 | Divisional application for international application |
Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20250519 Application number text: 1020207009105 Filing date: 20200330 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20250611 Comment text: Request for Examination of Application |