KR20250052483A - 디옥세탄 화합물 및 미생물의 검출을 위한 이의 용도 - Google Patents

디옥세탄 화합물 및 미생물의 검출을 위한 이의 용도 Download PDF

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KR20250052483A
KR20250052483A KR1020257011217A KR20257011217A KR20250052483A KR 20250052483 A KR20250052483 A KR 20250052483A KR 1020257011217 A KR1020257011217 A KR 1020257011217A KR 20257011217 A KR20257011217 A KR 20257011217A KR 20250052483 A KR20250052483 A KR 20250052483A
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alkyl
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Korean (ko)
Inventor
도론 샤밧
미갈 엘리 로스-콘포티
니르 하나냐
오리 그린
우르스 스피츠
루카스 윅
줄리안 이쎈
라파엘 보버그
리카르도 크리비우
주자나 밥야코바
춘얀 야오
Original Assignee
네미스 테크놀로지스 아게
라모트 앳 텔-아비브 유니버시티 리미티드
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Publication of KR20250052483A publication Critical patent/KR20250052483A/ko
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    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/10—Enterobacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/045—Culture media therefor
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14—Streptococcus; Staphylococcus
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/22—Testing for sterility conditions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G01N21/763—Bioluminescence
    • C—CHEMISTRY; METALLURGY
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2304/00—Chemical means of detecting microorganisms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • General Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Chemistry (AREA)
KR1020257011217A 2018-05-25 2019-05-24 디옥세탄 화합물 및 미생물의 검출을 위한 이의 용도 Pending KR20250052483A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP18174403.8 2018-05-25
EP18174403 2018-05-25
PCT/EP2019/063418 WO2019224338A1 (en) 2018-05-25 2019-05-24 Dioxetane compounds and their use for the detection of microorganisms
KR1020207037220A KR20210013620A (ko) 2018-05-25 2019-05-24 디옥세탄 화합물 및 미생물의 검출을 위한 이의 용도

Related Parent Applications (1)

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KR1020207037220A Division KR20210013620A (ko) 2018-05-25 2019-05-24 디옥세탄 화합물 및 미생물의 검출을 위한 이의 용도

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KR20250052483A true KR20250052483A (ko) 2025-04-18

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KR1020257011217A Pending KR20250052483A (ko) 2018-05-25 2019-05-24 디옥세탄 화합물 및 미생물의 검출을 위한 이의 용도
KR1020207037220A Pending KR20210013620A (ko) 2018-05-25 2019-05-24 디옥세탄 화합물 및 미생물의 검출을 위한 이의 용도

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Country Status (6)

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US (2) US11649475B2 (enExample)
EP (1) EP3802511A1 (enExample)
JP (1) JP7462574B2 (enExample)
KR (2) KR20250052483A (enExample)
CN (1) CN112204020B (enExample)
WO (1) WO2019224338A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020520981A (ja) * 2017-05-24 2020-07-16 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． プロテアーゼのイメージング／検出のための化学発光プローブ
EP4107150A4 (en) * 2020-02-19 2023-08-16 Ramot at Tel-Aviv University Ltd. CHEMILUMINESCENCE PROBES FOR TUBERCULOSIS
WO2025079067A1 (en) * 2023-10-10 2025-04-17 Ramot At Tel-Aviv University Ltd. Chemiluminescent array-based assay for rapid identification of bacteria and method of use
WO2025191551A1 (en) * 2024-03-13 2025-09-18 Ramot At Tel-Aviv University Ltd. Phenoxy-dioxetanes-based chemiluminescence probes and uses thereof
CN119409748A (zh) * 2025-01-06 2025-02-11 四川省医学科学院·四川省人民医院 一种N-乙酰-β-D-氨基葡萄糖酶的化学发光探针、试剂盒及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223402A (en) 1990-08-30 1993-06-29 Difco Laboratories Method of detecting microbes utilizing chemiluminescent compound
EP1735621A4 (en) 2004-04-14 2012-12-12 Brij P Giri NEW ULTRA-SENSITIVE CHEMIELUMINESCENSE SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES
WO2009139811A2 (en) 2008-05-15 2009-11-19 Tianxin Wang Chemiluminescent methods and reagents for analyte detection
CN102183512B (zh) 2011-02-15 2012-09-19 杭州师范大学 一种基于化学发光原理的活细胞检测方法
CN106061949A (zh) 2014-01-17 2016-10-26 小利兰·斯坦福大学理事会 用于检测表达金属‑β‑内酰胺酶的细菌的基于6,7‑反式头孢菌素的探针
EP3408349B1 (en) 2016-01-26 2021-03-31 Ramot at Tel-Aviv University Ltd. Chemiluminescent fluorophor-linked adamantylene-dioxetane probes as diagnostics or in-vivo imaging sensors
CN106279178B (zh) 2016-07-18 2019-01-18 华东理工大学 耐碳青霉烯类抗生素病菌的荧光探针及合成方法与应用
JP2020520981A (ja) 2017-05-24 2020-07-16 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． プロテアーゼのイメージング／検出のための化学発光プローブ

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Publication number Publication date
US11649475B2 (en) 2023-05-16
JP7462574B2 (ja) 2024-04-05
US20210214766A1 (en) 2021-07-15
WO2019224338A1 (en) 2019-11-28
US20230265480A1 (en) 2023-08-24
EP3802511A1 (en) 2021-04-14
CN112204020A (zh) 2021-01-08
KR20210013620A (ko) 2021-02-04
CN112204020B (zh) 2023-11-14
JP2021525273A (ja) 2021-09-24

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