KR20250030535A - 인간 면역 반응을 조정하기 위한 이미다조피리미딘의 용도 - Google Patents

인간 면역 반응을 조정하기 위한 이미다조피리미딘의 용도 Download PDF

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KR20250030535A
KR20250030535A KR1020257006482A KR20257006482A KR20250030535A KR 20250030535 A KR20250030535 A KR 20250030535A KR 1020257006482 A KR1020257006482 A KR 1020257006482A KR 20257006482 A KR20257006482 A KR 20257006482A KR 20250030535 A KR20250030535 A KR 20250030535A
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antigen
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compound
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오퍼 레비
데이비드 제이. 다울링
프란체스코 보리엘로
데이비드 에이. 스콧
스펜서 이. 브라이트만
프레데릭 페루
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칠드런'즈 메디컬 센터 코포레이션
다나-파버 캔서 인스티튜트 인크.
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KR1020257006482A 2017-11-14 2018-11-14 인간 면역 반응을 조정하기 위한 이미다조피리미딘의 용도 Pending KR20250030535A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762586137P 2017-11-14 2017-11-14
US62/586,137 2017-11-14
PCT/US2018/061135 WO2019099578A1 (en) 2017-11-14 2018-11-14 Use of imidazopyrimidine for modulating human immune response
KR1020207016958A KR102775718B1 (ko) 2017-11-14 2018-11-14 인간 면역 반응을 조정하기 위한 이미다조피리미딘의 용도

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KR1020207016958A Active KR102775718B1 (ko) 2017-11-14 2018-11-14 인간 면역 반응을 조정하기 위한 이미다조피리미딘의 용도

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US (1) US11730810B2 (cg-RX-API-DMAC7.html)
EP (1) EP3710007A4 (cg-RX-API-DMAC7.html)
JP (2) JP7382316B2 (cg-RX-API-DMAC7.html)
KR (2) KR20250030535A (cg-RX-API-DMAC7.html)
CN (1) CN111587114A (cg-RX-API-DMAC7.html)
WO (1) WO2019099578A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3710007A4 (en) * 2017-11-14 2021-12-15 Children's Medical Center Corporation USE OF IMIDAZOPYRIMIDINE TO MODULATE HUMAN IMMUNE RESPONSE
KR102740831B1 (ko) 2017-11-14 2024-12-11 칠드런'즈 메디컬 센터 코포레이션 신규 이미다조피리미딘 화합물 및 그의 용도
CA3204437A1 (en) * 2021-01-15 2022-07-21 Bali Pulendran Adjuvants to stimulate broad and persistent innate immunity against diverse antigens
WO2024151501A1 (en) * 2023-01-09 2024-07-18 The Children's Medical Center Corporation Novel imidazopyrimidine compound and uses thereof

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69524598T2 (de) 1994-06-20 2002-07-11 Takeda Chemical Industries, Ltd. Kondensierte imidazolderivate, ihre herstellung und verwendung
ES2237470T3 (es) 1999-11-10 2005-08-01 Ortho-Mcneil Pharmaceutical, Inc. 2-aril-3-(heteroaril)-imidazo(1,2-alfa)pirimidinas sustituidas; y composiciones farmaceuticas y procedimientos asociados.
JP2001302667A (ja) * 2000-04-28 2001-10-31 Bayer Ag イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
EP1294723A1 (en) * 2000-05-24 2003-03-26 MERCK SHARP & DOHME LTD. 3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
GB0128499D0 (en) 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
ES2328047T3 (es) 2004-03-19 2009-11-06 Warner-Lambert Company Llc Derivados de imidazopiridina e imidazopirimidina como agentes antibacterianos.
BRPI0513811A (pt) 2004-07-27 2008-07-15 Gilead Sciences Inc imidazo [4,5-d] pirimidinas, seus usos e processos de preparação
US20080193468A1 (en) * 2004-09-08 2008-08-14 Children's Medical Center Corporation Method for Stimulating the Immune Response of Newborns
DK1910384T3 (da) * 2005-08-04 2012-12-17 Sirtris Pharmaceuticals Inc Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
EP1955077B1 (en) 2005-12-02 2012-06-13 Sirtris Pharmaceuticals, Inc. Mass spectrometry assays for acetyltransferase/deacetylase activity
WO2008027812A2 (en) 2006-08-28 2008-03-06 Forest Laboratories Holdings Limited Imidazopyridine and imidazopyrimidine derivatives
RS54510B1 (sr) 2006-11-22 2016-06-30 Incyte Holdings Corporation Imidazotriazini i imidazopirimidini kao inhibitori kinaze
RU2364597C1 (ru) 2007-12-14 2009-08-20 Андрей Александрович Иващенко ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ Hh-СИГНАЛЬНОГО КАСКАДА, ЛЕКАРСТВЕННЫЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С АББЕРАНТНОЙ АКТИВНОСТЬЮ Hh СИГНАЛЬНОЙ СИСТЕМЫ
EP2103614A1 (en) 2008-03-18 2009-09-23 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyrimidine, imidazopyrazine and imidazopyridazine derivatives as melanocortin-4 receptor modulators
US20100168084A1 (en) * 2008-05-08 2010-07-01 Huber L Julie Therapeutic compounds and related methods of use
FR2933982A1 (fr) 2008-07-18 2010-01-22 Sanofi Aventis Nouveaux derives imidazo°1,2-a!pyrimidine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
JP5694345B2 (ja) * 2009-10-22 2015-04-01 ギリアード サイエンシーズ, インコーポレイテッド Toll様受容体の調節因子
TWI617559B (zh) 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 2-芳基咪唑并[1,2-b]嗒.2-苯基咪唑并[1,2-a]吡啶,和2-苯基咪唑并[1,2-a]吡衍生物
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
CN103570625A (zh) * 2012-07-19 2014-02-12 南京英派药业有限公司 N-(3-杂芳基芳基)-4-芳基芳基甲酰胺和类似物作为Hedgehog通路抑制剂及其应用
US9695212B2 (en) 2012-12-13 2017-07-04 Aduro Biotech, Inc. Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
JP6356160B2 (ja) 2013-02-25 2018-07-11 ザ スクリプス リサーチ インスティテュート ネオセプチン:低分子アジュバント
EP2964648B1 (en) * 2013-03-05 2016-11-16 Merck Patent GmbH 9-(aryl or heteroaryl)-2-(pyrazolyl, pyrrolidinyl or cyclopentyl)aminopurine derivatives as anticancer agents
WO2014151729A1 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
UY35400A (es) 2013-03-15 2014-10-31 Novartis Ag Compuestos y composiciones para el tratamiento de enfermedades parasitarias
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
CN103467590B (zh) 2013-09-02 2016-04-13 深圳大学 生物偶联体、制备其的嘌呤类化合物、合成方法、药用制剂以及其在免疫调节中的应用
GB201321736D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
US10821175B2 (en) * 2014-02-25 2020-11-03 Merck Sharp & Dohme Corp. Lipid nanoparticle vaccine adjuvants and antigen delivery systems
BR112016026951B1 (pt) 2014-06-25 2022-09-20 F. Hoffmann-La Roche Ag Imidazo[1,2-a]pirazin-1-il-benzamida, seu uso, e composições farmacêuticas
TW201643143A (zh) 2015-03-13 2016-12-16 國立大學法人北海道大學 抑制氧化壓迫引發的神經細胞死亡之化合物
CN107849084B (zh) * 2015-12-03 2021-09-14 葛兰素史密斯克莱知识产权发展有限公司 作为sting调节剂的环状嘌呤二核苷酸
KR102740831B1 (ko) 2017-11-14 2024-12-11 칠드런'즈 메디컬 센터 코포레이션 신규 이미다조피리미딘 화합물 및 그의 용도
EP3710007A4 (en) * 2017-11-14 2021-12-15 Children's Medical Center Corporation USE OF IMIDAZOPYRIMIDINE TO MODULATE HUMAN IMMUNE RESPONSE

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KR20200088398A (ko) 2020-07-22
JP2023175686A (ja) 2023-12-12
CN111587114A (zh) 2020-08-25
US20200282048A1 (en) 2020-09-10
WO2019099578A8 (en) 2019-06-20
US11730810B2 (en) 2023-08-22

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