KR20250023993A - L-오르니틴 페닐아세테이트의 제제 - Google Patents
L-오르니틴 페닐아세테이트의 제제 Download PDFInfo
- Publication number
- KR20250023993A KR20250023993A KR1020247042587A KR20247042587A KR20250023993A KR 20250023993 A KR20250023993 A KR 20250023993A KR 1020247042587 A KR1020247042587 A KR 1020247042587A KR 20247042587 A KR20247042587 A KR 20247042587A KR 20250023993 A KR20250023993 A KR 20250023993A
- Authority
- KR
- South Korea
- Prior art keywords
- phenylacetylglutamine
- plasma
- phenylacetate
- auc
- oral pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 165
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims description 85
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562255300P | 2015-11-13 | 2015-11-13 | |
| US62/255,300 | 2015-11-13 | ||
| US201662276754P | 2016-01-08 | 2016-01-08 | |
| US62/276,754 | 2016-01-08 | ||
| US15/133,087 US20160338982A1 (en) | 2015-04-20 | 2016-04-19 | Formulations of l-ornithine phenylacetate |
| US15/133,087 | 2016-04-19 | ||
| PCT/US2016/061678 WO2017083758A1 (en) | 2015-11-13 | 2016-11-11 | Formulation of l-ornithine phenylacetate |
| KR1020187016373A KR20180086431A (ko) | 2015-11-13 | 2016-11-11 | L-오르니틴 페닐아세테이트의 제제 |
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| CN111295187A (zh) | 2017-08-14 | 2020-06-16 | 胺细拉健康公司 | 用于治疗肝脏疾病的氨基酸组合物 |
| MA52971A (fr) | 2018-06-20 | 2021-04-28 | Axcella Health Inc | Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle |
| JP2022552016A (ja) * | 2019-10-16 | 2022-12-14 | オセラ セラピューティクス， インコーポレイテッド | 高アンモニア血症を治療するためのオルニチンフェニル酢酸塩の投与量および使用 |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
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| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
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| WO2006056794A1 (en) * | 2004-11-26 | 2006-06-01 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| DE102007009243A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
| AU2015221466B2 (en) * | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| CN104230730B (zh) * | 2009-04-03 | 2017-05-24 | 欧塞拉治疗有限公司 | L‑鸟氨酸苯乙酸盐及其制备方法 |
| NZ615091A (en) * | 2009-06-08 | 2015-03-27 | Ucl Business Plc | Treatment of portal hypertension and restoration of liver function using l-ornithine phenylacetate |
| AU2014250643B2 (en) | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| KR101888215B1 (ko) | 2010-10-06 | 2018-09-20 | 오세라 테라퓨틱스, 아이엔씨. | L-오르니틴 페닐아세테이트의 제조 방법 |
| CN102993037B (zh) * | 2012-11-20 | 2015-03-04 | 南京工业大学 | 一种l-鸟氨酸苯乙酸盐的制备方法 |
| CN103705490B (zh) * | 2013-10-31 | 2016-08-17 | 蚌埠丰原医药科技发展有限公司 | 一种门冬氨酸鸟氨酸的缓释制剂及其制备工艺 |
| NZ732632A (en) * | 2014-11-24 | 2021-07-30 | Ucl Business Ltd | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| JP2018513171A (ja) * | 2015-04-20 | 2018-05-24 | オセラ セラピューティクス， インコーポレイテッド | Ｌ−オルニチンフェニルアセテート製剤 |
| JP6990170B2 (ja) * | 2015-08-18 | 2022-01-12 | オセラ セラピューティクス， インコーポレイテッド | Ｌ－オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる筋肉喪失の治療および予防 |
| US20200206174A1 (en) * | 2015-09-25 | 2020-07-02 | Ocera Therapeutics, Inc. | Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
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| BR112018009349A8 (pt) | 2019-02-26 |
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| EP3373923A1 (en) | 2018-09-19 |
| BR112018009349A2 (pt) | 2018-11-13 |
| AU2016353350A1 (en) | 2018-05-10 |
| EP3373923A4 (en) | 2019-07-03 |
| AU2021290236A1 (en) | 2022-02-10 |
| MX2018005088A (es) | 2019-05-16 |
| JP7294807B2 (ja) | 2023-06-20 |
| MX2022001517A (es) | 2022-11-16 |
| CN108366983A (zh) | 2018-08-03 |
| RU2018113801A (ru) | 2019-12-16 |
| CN113768863A (zh) | 2021-12-10 |
| IL258630A (en) | 2018-06-28 |
| MX389926B (es) | 2025-03-20 |
| AU2016353350B2 (en) | 2021-09-23 |
| CA3004331A1 (en) | 2017-05-18 |
| WO2017083758A1 (en) | 2017-05-18 |
| KR20180086431A (ko) | 2018-07-31 |
| SG11201802987UA (en) | 2018-05-30 |
| IL258630B2 (en) | 2023-08-01 |
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