JP7294807B2 - Ｌ－オルニチンフェニルアセテート製剤 - Google Patents
Ｌ－オルニチンフェニルアセテート製剤 Download PDFInfo
- Publication number
- JP7294807B2 JP7294807B2 JP2018524369A JP2018524369A JP7294807B2 JP 7294807 B2 JP7294807 B2 JP 7294807B2 JP 2018524369 A JP2018524369 A JP 2018524369A JP 2018524369 A JP2018524369 A JP 2018524369A JP 7294807 B2 JP7294807 B2 JP 7294807B2
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- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- immediate release
- oral pharmaceutical
- release oral
- ornithine phenylacetate
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 62
- 238000009472 formulation Methods 0.000 title claims description 50
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 176
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims description 89
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| US10596136B2 (en) | 2018-06-20 | 2020-03-24 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| CN114786662A (zh) * | 2019-10-16 | 2022-07-22 | 欧塞拉治疗有限公司 | 鸟氨酸苯乙酸盐用于治疗高氨血症的剂量和用途 |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
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| JP2018513171A (ja) | 2015-04-20 | 2018-05-24 | オセラ セラピューティクス， インコーポレイテッド | Ｌ−オルニチンフェニルアセテート製剤 |
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| ES2652187T3 (es) * | 2009-04-03 | 2018-01-31 | Ocera Therapeutics, Inc. | Fenilacetato de l-ornitina y métodos para elaborar el mismo |
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| JP2012529523A (ja) | 2009-06-08 | 2012-11-22 | ユーシーエル ビジネス ピーエルシー | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
| JP2018513171A (ja) | 2015-04-20 | 2018-05-24 | オセラ セラピューティクス， インコーポレイテッド | Ｌ−オルニチンフェニルアセテート製剤 |
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| EP3373923A4 (en) | 2019-07-03 |
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| BR112018009349A8 (pt) | 2019-02-26 |
| MX2018005088A (es) | 2019-05-16 |
| RU2018113801A (ru) | 2019-12-16 |
| BR112018009349A2 (pt) | 2018-11-13 |
| JP2018533601A (ja) | 2018-11-15 |
| MX2022001517A (es) | 2022-11-16 |
| IL258630B1 (en) | 2023-04-01 |
| IL258630A (en) | 2018-06-28 |
| AU2016353350B2 (en) | 2021-09-23 |
| KR20180086431A (ko) | 2018-07-31 |
| CN113768863A (zh) | 2021-12-10 |
| JP2022058446A (ja) | 2022-04-12 |
| AU2021290236A1 (en) | 2022-02-10 |
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