JP7294807B2 - Ｌ－オルニチンフェニルアセテート製剤 - Google Patents
Ｌ－オルニチンフェニルアセテート製剤 Download PDFInfo
- Publication number
- JP7294807B2 JP7294807B2 JP2018524369A JP2018524369A JP7294807B2 JP 7294807 B2 JP7294807 B2 JP 7294807B2 JP 2018524369 A JP2018524369 A JP 2018524369A JP 2018524369 A JP2018524369 A JP 2018524369A JP 7294807 B2 JP7294807 B2 JP 7294807B2
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- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- immediate release
- oral pharmaceutical
- release oral
- ornithine phenylacetate
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 62
- 238000009472 formulation Methods 0.000 title claims description 50
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 176
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims description 89
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| MA49906A (fr) | 2017-08-14 | 2020-06-24 | Axcella Health Inc | Acides aminés à chaîne ramifiée pour le traitement d'une maladie du foie |
| EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
| KR20220110727A (ko) * | 2019-10-16 | 2022-08-09 | 오세라 테라퓨틱스, 아이엔씨. | 고암모니아혈증의 치료를 위한 오르니틴 페닐아세테이트의 투여량 및 용도 |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
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| JP2012529523A (ja) | 2009-06-08 | 2012-11-22 | ユーシーエル ビジネス ピーエルシー | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
| JP2018513171A (ja) | 2015-04-20 | 2018-05-24 | オセラ セラピューティクス， インコーポレイテッド | Ｌ−オルニチンフェニルアセテート製剤 |
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| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| PT2319581E (pt) * | 2004-11-26 | 2015-06-30 | Ucl Business Plc | Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática |
| GB0426141D0 (en) * | 2004-11-26 | 2004-12-29 | Ucl Biomedica Plc | Treatment |
| DE102007009243A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
| AU2015221466B2 (en) | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| DK3263100T3 (da) * | 2009-04-03 | 2020-05-11 | Ocera Therapeutics Inc | L-ornithinphenylacetat og fremgangsmåder til fremstilling deraf |
| AU2014250643B2 (en) | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| MX360062B (es) * | 2010-10-06 | 2018-10-22 | Ocera Therapeutics Inc | Metodos de elaboracion de fenilacetato de l-ornitina. |
| CN102993037B (zh) * | 2012-11-20 | 2015-03-04 | 南京工业大学 | 一种l-鸟氨酸苯乙酸盐的制备方法 |
| CN103705490B (zh) * | 2013-10-31 | 2016-08-17 | 蚌埠丰原医药科技发展有限公司 | 一种门冬氨酸鸟氨酸的缓释制剂及其制备工艺 |
| CN107206021B (zh) * | 2014-11-24 | 2021-09-03 | Ucl商业有限公司 | 使用降氨疗法治疗与肝星状细胞激活相关的疾病 |
| EP3337473A4 (en) * | 2015-08-18 | 2019-04-17 | Ocera Therapeutics, Inc. | TREATMENT AND PREVENTION OF MUSCLE WOUND BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE |
| WO2017053613A1 (en) * | 2015-09-25 | 2017-03-30 | Ocera Therapeutics, Inc. | Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
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| JP2012529523A (ja) | 2009-06-08 | 2012-11-22 | ユーシーエル ビジネス ピーエルシー | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
| JP2018513171A (ja) | 2015-04-20 | 2018-05-24 | オセラ セラピューティクス， インコーポレイテッド | Ｌ−オルニチンフェニルアセテート製剤 |
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| CN108366983A (zh) | 2018-08-03 |
| EP3373923A4 (en) | 2019-07-03 |
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| IL258630B1 (en) | 2023-04-01 |
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| SG11201802987UA (en) | 2018-05-30 |
| WO2017083758A1 (en) | 2017-05-18 |
| RU2018113801A (ru) | 2019-12-16 |
| AU2021290236A1 (en) | 2022-02-10 |
| MX2018005088A (es) | 2019-05-16 |
| BR112018009349A2 (pt) | 2018-11-13 |
| KR20180086431A (ko) | 2018-07-31 |
| AU2016353350B2 (en) | 2021-09-23 |
| IL258630B2 (en) | 2023-08-01 |
| EP3373923A1 (en) | 2018-09-19 |
| BR112018009349A8 (pt) | 2019-02-26 |
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