KR20240108380A - 이데베논 유도체 및 식물의 치료에서의 그의 용도 - Google Patents
이데베논 유도체 및 식물의 치료에서의 그의 용도 Download PDFInfo
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- KR20240108380A KR20240108380A KR1020247012225A KR20247012225A KR20240108380A KR 20240108380 A KR20240108380 A KR 20240108380A KR 1020247012225 A KR1020247012225 A KR 1020247012225A KR 20247012225 A KR20247012225 A KR 20247012225A KR 20240108380 A KR20240108380 A KR 20240108380A
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- South Korea
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- compound
- aryl
- dithiol
- alkyl
- Prior art date
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- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A—HUMAN NECESSITIES
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
Landscapes
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- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
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| GB2113117.2A GB2610815A (en) | 2021-09-14 | 2021-09-14 | Compounds |
| PCT/GB2022/052325 WO2023041906A1 (en) | 2021-09-14 | 2022-09-14 | Idebenone derivatives and their use in treating plants |
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| WO2025104452A1 (en) | 2023-11-17 | 2025-05-22 | Mitorx Therapeutics Ltd | Compounds for use in treatment |
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| DE1154112B (de) * | 1961-04-21 | 1963-09-12 | Bayer Ag | Verfahren zur Herstellung von Mercaptomethylnaphthochinonderivaten |
| AU2004266988B2 (en) * | 2003-08-22 | 2011-05-26 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| WO2009111576A2 (en) * | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc. | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| US8263094B2 (en) | 2008-09-23 | 2012-09-11 | Eastman Chemical Company | Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof |
| JP2016515526A (ja) * | 2013-03-15 | 2016-05-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体 |
| CN107226789B (zh) * | 2017-05-09 | 2019-11-08 | 北京大学 | 氨基二硫代甲酸酯类化合物、其制备方法以及在制备抗肿瘤药物中的用途 |
| CN110950749B (zh) * | 2018-09-26 | 2023-07-25 | 中国科学院广州生物医药与健康研究院 | Ido抑制剂及其制备方法和应用 |
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| CN118234716A (zh) | 2024-06-21 |
| JP2024535017A (ja) | 2024-09-26 |
| GB2610815A (en) | 2023-03-22 |
| MX2024003214A (es) | 2024-07-30 |
| CA3231394A1 (en) | 2023-03-23 |
| WO2023041906A1 (en) | 2023-03-23 |
| US20240400536A1 (en) | 2024-12-05 |
| AU2022347098A1 (en) | 2024-04-04 |
| GB202113117D0 (en) | 2021-10-27 |
| EP4396174A1 (en) | 2024-07-10 |
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