JP2024535017A - イデベノン誘導体及び植物の処置におけるそれらの使用 - Google Patents

イデベノン誘導体及び植物の処置におけるそれらの使用 Download PDF

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JP2024535017A
JP2024535017A JP2024516411A JP2024516411A JP2024535017A JP 2024535017 A JP2024535017 A JP 2024535017A JP 2024516411 A JP2024516411 A JP 2024516411A JP 2024516411 A JP2024516411 A JP 2024516411A JP 2024535017 A JP2024535017 A JP 2024535017A
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compound
aryl
groups
dithiol
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JP2024535017A5 (enExample
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マシュー ホワイトマン
ロベルタ トレグロッサ
マーク ウッド
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ミトアールエックス セラピューティクス リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2024516411A 2021-09-14 2022-09-14 イデベノン誘導体及び植物の処置におけるそれらの使用 Pending JP2024535017A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2113117.2 2021-09-14
GB2113117.2A GB2610815A (en) 2021-09-14 2021-09-14 Compounds
PCT/GB2022/052325 WO2023041906A1 (en) 2021-09-14 2022-09-14 Idebenone derivatives and their use in treating plants

Publications (2)

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JP2024535017A true JP2024535017A (ja) 2024-09-26
JP2024535017A5 JP2024535017A5 (enExample) 2026-01-09

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JP2024516411A Pending JP2024535017A (ja) 2021-09-14 2022-09-14 イデベノン誘導体及び植物の処置におけるそれらの使用

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US (1) US20240400536A1 (enExample)
EP (1) EP4396174A1 (enExample)
JP (1) JP2024535017A (enExample)
KR (1) KR20240108380A (enExample)
CN (1) CN118234716A (enExample)
AU (1) AU2022347098A1 (enExample)
CA (1) CA3231394A1 (enExample)
GB (1) GB2610815A (enExample)
MX (1) MX2024003214A (enExample)
WO (1) WO2023041906A1 (enExample)

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Publication number Priority date Publication date Assignee Title
WO2025104452A1 (en) 2023-11-17 2025-05-22 Mitorx Therapeutics Ltd Compounds for use in treatment

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB940536A (en) * 1961-04-21 1963-10-30 Bayer Ag New sulphur-containing naphthoquinones
JP2011513423A (ja) * 2008-03-05 2011-04-28 エジソン ファーマシューティカルズ， インコーポレイテッド 酸化ストレス疾患の処置のための２−置換−ｐ−キノン誘導体
JP2016515526A (ja) * 2013-03-15 2016-05-30 エジソン ファーマシューティカルズ， インコーポレイテッド 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体
CN107226789A (zh) * 2017-05-09 2017-10-03 北京大学 氨基二硫代甲酸酯类化合物、其制备方法以及在制备抗肿瘤药物中的用途
CN110950749A (zh) * 2018-09-26 2020-04-03 中国科学院广州生物医药与健康研究院 Ido抑制剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004266988B2 (en) * 2003-08-22 2011-05-26 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
US8263094B2 (en) 2008-09-23 2012-09-11 Eastman Chemical Company Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids and preparation thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB940536A (en) * 1961-04-21 1963-10-30 Bayer Ag New sulphur-containing naphthoquinones
JP2011513423A (ja) * 2008-03-05 2011-04-28 エジソン ファーマシューティカルズ， インコーポレイテッド 酸化ストレス疾患の処置のための２−置換−ｐ−キノン誘導体
JP2016515526A (ja) * 2013-03-15 2016-05-30 エジソン ファーマシューティカルズ， インコーポレイテッド 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体
CN107226789A (zh) * 2017-05-09 2017-10-03 北京大学 氨基二硫代甲酸酯类化合物、其制备方法以及在制备抗肿瘤药物中的用途
CN110950749A (zh) * 2018-09-26 2020-04-03 中国科学院广州生物医药与健康研究院 Ido抑制剂及其制备方法和应用

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY, vol. 25, JPN7026002164, 1986, pages 3378 - 3390, ISSN: 0005862895 *
BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 80, JPN7026002162, 2016, pages 1464 - 1469, ISSN: 0005862893 *
BOLLETTINO CHIMICO FARMACEUTICO, vol. 143, JPN7026002160, 2004, pages 299 - 307, ISSN: 0005862891 *
CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 21, JPN7026002165, 2021, pages 2258 - 2271, ISSN: 0005862896 *
CYTOMETRY, PART A, vol. 52, JPN7026002163, 2003, pages 28 - 35, ISSN: 0005862894 *
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 138, JPN7026002159, 2017, pages 343 - 352, ISSN: 0005862890 *
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 294, JPN7026002161, 2019, pages 679 - 696, ISSN: 0005862892 *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, JPN7026002158, 2013, pages 3168 - 3176, ISSN: 0005862889 *
MOLECULES, vol. Vol.22(887), JPN7026002157, 2017, pages 1 - 15, ISSN: 0005862888 *

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Publication number Publication date
KR20240108380A (ko) 2024-07-09
CN118234716A (zh) 2024-06-21
GB2610815A (en) 2023-03-22
MX2024003214A (es) 2024-07-30
CA3231394A1 (en) 2023-03-23
WO2023041906A1 (en) 2023-03-23
US20240400536A1 (en) 2024-12-05
AU2022347098A1 (en) 2024-04-04
GB202113117D0 (en) 2021-10-27
EP4396174A1 (en) 2024-07-10

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