KR20240054994A - AhR 시그널링의 조절에 유용한 화합물 - Google Patents

AhR 시그널링의 조절에 유용한 화합물 Download PDF

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Publication number
KR20240054994A
KR20240054994A KR1020247007991A KR20247007991A KR20240054994A KR 20240054994 A KR20240054994 A KR 20240054994A KR 1020247007991 A KR1020247007991 A KR 1020247007991A KR 20247007991 A KR20247007991 A KR 20247007991A KR 20240054994 A KR20240054994 A KR 20240054994A
Authority
KR
South Korea
Prior art keywords
indol
dihydro
pyrimido
oxazin
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247007991A
Other languages
English (en)
Korean (ko)
Inventor
마이클 스톡스
마크 그라함
제임스 히친
톰 매키낼리
빈첸조 칠리브라시
샌디 콤파인
다비데 스브라바티
Original Assignee
재규어 테라퓨틱스 피티이 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 재규어 테라퓨틱스 피티이 리미티드 filed Critical 재규어 테라퓨틱스 피티이 리미티드
Publication of KR20240054994A publication Critical patent/KR20240054994A/ko
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020247007991A 2021-09-02 2022-08-31 AhR 시그널링의 조절에 유용한 화합물 Pending KR20240054994A (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
SG10202109626X 2021-09-02
SG10202109626X 2021-09-02
SG10202109806R 2021-09-07
SG10202109806R 2021-09-07
SG10202250248T 2022-06-21
SG10202250248T 2022-06-21
SG10202250348V 2022-06-30
SG10202250348V 2022-06-30
SG10202250775C 2022-08-18
SG10202250775C 2022-08-18
PCT/SG2022/050633 WO2023033740A1 (en) 2021-09-02 2022-08-31 Compounds useful in modulation of ahr signalling

Publications (1)

Publication Number Publication Date
KR20240054994A true KR20240054994A (ko) 2024-04-26

Family

ID=84362966

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247007991A Pending KR20240054994A (ko) 2021-09-02 2022-08-31 AhR 시그널링의 조절에 유용한 화합물

Country Status (6)

Country Link
US (1) US20250129092A1 (https=)
EP (1) EP4396191B1 (https=)
JP (1) JP2024533046A (https=)
KR (1) KR20240054994A (https=)
CN (1) CN118076613A (https=)
WO (1) WO2023033740A1 (https=)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019012431A (es) * 2017-04-21 2020-08-03 Ikena Oncology Inc Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
WO2020050409A1 (en) * 2018-09-07 2020-03-12 Otsuka Pharmaceutical Co., Ltd. Heterocyclic compound

Also Published As

Publication number Publication date
EP4396191C0 (en) 2026-02-18
US20250129092A1 (en) 2025-04-24
EP4396191B1 (en) 2026-02-18
EP4396191A1 (en) 2024-07-10
WO2023033740A9 (en) 2023-12-28
CN118076613A (zh) 2024-05-24
JP2024533046A (ja) 2024-09-12
WO2023033740A1 (en) 2023-03-09

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KR20240054994A (ko) AhR 시그널링의 조절에 유용한 화합물

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