JP2024533046A - ＡｈＲシグナル伝達の調節に有用な化合物 - Google Patents

ＡｈＲシグナル伝達の調節に有用な化合物 Download PDF

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Publication number
JP2024533046A
JP2024533046A JP2024509097A JP2024509097A JP2024533046A JP 2024533046 A JP2024533046 A JP 2024533046A JP 2024509097 A JP2024509097 A JP 2024509097A JP 2024509097 A JP2024509097 A JP 2024509097A JP 2024533046 A JP2024533046 A JP 2024533046A
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JP
Japan
Prior art keywords
indol
oxazin
pyrimido
dihydro
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2024509097A
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English (en)
Japanese (ja)
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JP2024533046A5 (https=
Inventor
ストックス，マイケル
グラハム，マーク
ヒッチン，ジェームス
マキナリー，トム
スィリブラシ，ヴィンチェンツォ
コンペイン，サンディ
サラバティ，ダヴィデ
Original Assignee
ジャグエーエイチアール セラピューティクス ピーティーイー リミテッド
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Publication of JP2024533046A publication Critical patent/JP2024533046A/ja
Publication of JP2024533046A5 publication Critical patent/JP2024533046A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2024509097A 2021-09-02 2022-08-31 ＡｈＲシグナル伝達の調節に有用な化合物 Pending JP2024533046A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
SG10202109626X 2021-09-02
SG10202109626X 2021-09-02
SG10202109806R 2021-09-07
SG10202109806R 2021-09-07
SG10202250248T 2022-06-21
SG10202250248T 2022-06-21
SG10202250348V 2022-06-30
SG10202250348V 2022-06-30
SG10202250775C 2022-08-18
SG10202250775C 2022-08-18
PCT/SG2022/050633 WO2023033740A1 (en) 2021-09-02 2022-08-31 Compounds useful in modulation of ahr signalling

Publications (2)

Publication Number Publication Date
JP2024533046A true JP2024533046A (ja) 2024-09-12
JP2024533046A5 JP2024533046A5 (https=) 2025-09-09

Family

ID=84362966

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024509097A Pending JP2024533046A (ja) 2021-09-02 2022-08-31 ＡｈＲシグナル伝達の調節に有用な化合物

Country Status (6)

Country Link
US (1) US20250129092A1 (https=)
EP (1) EP4396191B1 (https=)
JP (1) JP2024533046A (https=)
KR (1) KR20240054994A (https=)
CN (1) CN118076613A (https=)
WO (1) WO2023033740A1 (https=)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019012431A (es) * 2017-04-21 2020-08-03 Ikena Oncology Inc Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
WO2020050409A1 (en) * 2018-09-07 2020-03-12 Otsuka Pharmaceutical Co., Ltd. Heterocyclic compound

Also Published As

Publication number Publication date
EP4396191C0 (en) 2026-02-18
US20250129092A1 (en) 2025-04-24
EP4396191B1 (en) 2026-02-18
EP4396191A1 (en) 2024-07-10
KR20240054994A (ko) 2024-04-26
WO2023033740A9 (en) 2023-12-28
CN118076613A (zh) 2024-05-24
WO2023033740A1 (en) 2023-03-09

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