CN118076613A - 可用于调节AhR信号传导的化合物 - Google Patents
可用于调节AhR信号传导的化合物 Download PDFInfo
- Publication number
- CN118076613A CN118076613A CN202280058211.3A CN202280058211A CN118076613A CN 118076613 A CN118076613 A CN 118076613A CN 202280058211 A CN202280058211 A CN 202280058211A CN 118076613 A CN118076613 A CN 118076613A
- Authority
- CN
- China
- Prior art keywords
- oxazin
- pyrimido
- dihydro
- indol
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10202109626X | 2021-09-02 | ||
| SG10202109626X | 2021-09-02 | ||
| SG10202109806R | 2021-09-07 | ||
| SG10202109806R | 2021-09-07 | ||
| SG10202250248T | 2022-06-21 | ||
| SG10202250248T | 2022-06-21 | ||
| SG10202250348V | 2022-06-30 | ||
| SG10202250348V | 2022-06-30 | ||
| SG10202250775C | 2022-08-18 | ||
| SG10202250775C | 2022-08-18 | ||
| PCT/SG2022/050633 WO2023033740A1 (en) | 2021-09-02 | 2022-08-31 | Compounds useful in modulation of ahr signalling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118076613A true CN118076613A (zh) | 2024-05-24 |
Family
ID=84362966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280058211.3A Pending CN118076613A (zh) | 2021-09-02 | 2022-08-31 | 可用于调节AhR信号传导的化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20250129092A1 (https=) |
| EP (1) | EP4396191B1 (https=) |
| JP (1) | JP2024533046A (https=) |
| KR (1) | KR20240054994A (https=) |
| CN (1) | CN118076613A (https=) |
| WO (1) | WO2023033740A1 (https=) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019012431A (es) * | 2017-04-21 | 2020-08-03 | Ikena Oncology Inc | Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos. |
| WO2020050409A1 (en) * | 2018-09-07 | 2020-03-12 | Otsuka Pharmaceutical Co., Ltd. | Heterocyclic compound |
-
2022
- 2022-08-31 CN CN202280058211.3A patent/CN118076613A/zh active Pending
- 2022-08-31 EP EP22813354.2A patent/EP4396191B1/en active Active
- 2022-08-31 JP JP2024509097A patent/JP2024533046A/ja active Pending
- 2022-08-31 WO PCT/SG2022/050633 patent/WO2023033740A1/en not_active Ceased
- 2022-08-31 KR KR1020247007991A patent/KR20240054994A/ko active Pending
- 2022-08-31 US US18/687,040 patent/US20250129092A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4396191C0 (en) | 2026-02-18 |
| US20250129092A1 (en) | 2025-04-24 |
| EP4396191B1 (en) | 2026-02-18 |
| EP4396191A1 (en) | 2024-07-10 |
| KR20240054994A (ko) | 2024-04-26 |
| WO2023033740A9 (en) | 2023-12-28 |
| JP2024533046A (ja) | 2024-09-12 |
| WO2023033740A1 (en) | 2023-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |