KR20240049583A - 캄프토테신 유도체, 이의 약학 조성물 및 이의 응용 - Google Patents

캄프토테신 유도체, 이의 약학 조성물 및 이의 응용 Download PDF

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Publication number
KR20240049583A
KR20240049583A KR1020247009078A KR20247009078A KR20240049583A KR 20240049583 A KR20240049583 A KR 20240049583A KR 1020247009078 A KR1020247009078 A KR 1020247009078A KR 20247009078 A KR20247009078 A KR 20247009078A KR 20240049583 A KR20240049583 A KR 20240049583A
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KR
South Korea
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group
reaction solution
added
reaction
compound
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KR1020247009078A
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English (en)
Korean (ko)
Inventor
젠 리
펑 탕
야위안 푸
리펑 리우
춘얀 자오
렌홍 탕
진셩 렌
Original Assignee
심시어 자이밍 파마슈티컬 컴퍼니 리미티드
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Publication of KR20240049583A publication Critical patent/KR20240049583A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020247009078A 2021-08-19 2022-08-19 캄프토테신 유도체, 이의 약학 조성물 및 이의 응용 Pending KR20240049583A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN202110955364.5 2021-08-19
CN202110955364 2021-08-19
CN202111515247 2021-12-13
CN202111515247.3 2021-12-13
CN202210515797.3 2022-05-12
CN202210515797 2022-05-12
PCT/CN2022/113499 WO2023020605A1 (zh) 2021-08-19 2022-08-19 喜树碱衍生物、其药物组合物及其应用

Publications (1)

Publication Number Publication Date
KR20240049583A true KR20240049583A (ko) 2024-04-16

Family

ID=85239565

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247009078A Pending KR20240049583A (ko) 2021-08-19 2022-08-19 캄프토테신 유도체, 이의 약학 조성물 및 이의 응용

Country Status (8)

Country Link
US (1) US20250270227A1 (https=)
EP (1) EP4389752A4 (https=)
JP (1) JP2024532768A (https=)
KR (1) KR20240049583A (https=)
CN (1) CN117769555A (https=)
AU (1) AU2022330892A1 (https=)
CA (1) CA3228345A1 (https=)
WO (1) WO2023020605A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112023018676A2 (pt) 2021-03-18 2023-10-10 Seagen Inc Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco
WO2023178289A2 (en) * 2022-03-17 2023-09-21 Seagen Inc. Camptothecin conjugates
JP2025515988A (ja) * 2022-05-13 2025-05-23 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド カンプトテシン化合物、その調製方法及びその使用
CN119630672B (zh) * 2023-02-23 2026-01-30 一线医药（杭州）有限公司 喜树碱衍生物及其偶联物以及其制备方法和医药用途
KR20240149823A (ko) * 2023-04-06 2024-10-15 주식회사 피노바이오 항암 내성 극복을 위한 신규 캄토테신 유도체 및 이를 포함하는 항체-약물 접합체
CN120858098A (zh) * 2023-05-04 2025-10-28 四川科伦博泰生物医药股份有限公司 稠环化合物及其制备方法和应用
WO2024227439A1 (zh) * 2023-05-04 2024-11-07 四川科伦博泰生物医药股份有限公司 具有靶向作用的偶联物及其制备方法和用途
WO2025153001A1 (zh) * 2024-01-17 2025-07-24 北京泰德制药股份有限公司 含有噻唑[5,4-b]吡啶结构的抗体偶联药物及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0540099B1 (en) * 1991-10-29 1996-04-17 Glaxo Wellcome Inc. Water soluble camptothecin derivatives
CN1036197C (zh) * 1992-01-28 1997-10-22 格拉克索有限公司 水溶性喜树碱衍生物
JPH1171280A (ja) * 1997-06-26 1999-03-16 Tanabe Seiyaku Co Ltd 医薬組成物
BR112020020466A2 (pt) * 2018-04-06 2021-01-12 Seattle Genetics, Inc. Conjugados de peptídeo de camptotecina
TWI851577B (zh) * 2018-06-07 2024-08-11 美商思進公司 喜樹鹼結合物
SG11202110922QA (en) 2019-04-26 2021-10-28 Immunogen Inc Camptothecin derivatives
EP4628165A3 (en) * 2021-02-05 2026-03-11 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Camptothecin compound, preparation method therefor, and application thereof
EP4257154A4 (en) * 2021-02-09 2026-04-22 Medilink Therapeutics Suzhou Co Ltd CONJUGATED WITH A BIOACTIVE SUBSTANCE, ITS PREPARATION PROCESS AND ITS USE
IL308734A (en) * 2021-05-27 2024-01-01 Zymeworks Bc Inc Camptothecin analogues, conjugates and methods of use
US20240376120A1 (en) * 2021-09-01 2024-11-14 Shanghai Best-Link Bioscience, Llc Camptothecin compound, preparation method therefor and use thereof
WO2023178289A2 (en) * 2022-03-17 2023-09-21 Seagen Inc. Camptothecin conjugates
JP2025515988A (ja) * 2022-05-13 2025-05-23 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド カンプトテシン化合物、その調製方法及びその使用

Also Published As

Publication number Publication date
CA3228345A1 (en) 2023-02-23
US20250270227A1 (en) 2025-08-28
AU2022330892A1 (en) 2024-03-21
EP4389752A4 (en) 2025-08-20
CN117769555A (zh) 2024-03-26
JP2024532768A (ja) 2024-09-10
WO2023020605A1 (zh) 2023-02-23
EP4389752A1 (en) 2024-06-26

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Date Code Title Description
PA0105 International application

Patent event date: 20240318

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application