KR20240034205A - 항EGFRviii 항체, 폴리펩타이드, 상기 폴리펩타이드를 발현하는 세포, 상기 세포를 포함하는 의약 조성물, 상기 세포의 제조 방법 및 상기 폴리펩타이드를 코딩하는 염기서열을 포함하는 폴리뉴클레오티드 또는 벡터 - Google Patents

항EGFRviii 항체, 폴리펩타이드, 상기 폴리펩타이드를 발현하는 세포, 상기 세포를 포함하는 의약 조성물, 상기 세포의 제조 방법 및 상기 폴리펩타이드를 코딩하는 염기서열을 포함하는 폴리뉴클레오티드 또는 벡터 Download PDF

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KR20240034205A
KR20240034205A KR1020247003837A KR20247003837A KR20240034205A KR 20240034205 A KR20240034205 A KR 20240034205A KR 1020247003837 A KR1020247003837 A KR 1020247003837A KR 20247003837 A KR20247003837 A KR 20247003837A KR 20240034205 A KR20240034205 A KR 20240034205A
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amino acid
cells
acid sequence
seq
cell
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Korean (ko)
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코지 타마다
유키미 사코다
케이시 아다치
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노일 이뮨 바이오테크 가부시키가이샤
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    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4204—Epidermal growth factor receptors [EGFR]
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/42—Cancer antigens
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
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    • A61K2239/11—Antigen recognition domain
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KR1020247003837A 2021-07-16 2022-07-14 항EGFRviii 항체, 폴리펩타이드, 상기 폴리펩타이드를 발현하는 세포, 상기 세포를 포함하는 의약 조성물, 상기 세포의 제조 방법 및 상기 폴리펩타이드를 코딩하는 염기서열을 포함하는 폴리뉴클레오티드 또는 벡터 Pending KR20240034205A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2021-118056 2021-07-16
JP2021118056 2021-07-16
PCT/JP2022/027735 WO2023286840A1 (ja) 2021-07-16 2022-07-14 抗ＥＧＦＲｖｉｉｉ抗体、ポリペプチド、前記ポリペプチドを発現する細胞、前記細胞を含む医薬組成物、前記細胞の製造方法、及び、前記ポリペプチドをコードする塩基配列を含むポリヌクレオチド又はベクター

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KR20240034205A true KR20240034205A (ko) 2024-03-13

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KR1020247003837A Pending KR20240034205A (ko) 2021-07-16 2022-07-14 항EGFRviii 항체, 폴리펩타이드, 상기 폴리펩타이드를 발현하는 세포, 상기 세포를 포함하는 의약 조성물, 상기 세포의 제조 방법 및 상기 폴리펩타이드를 코딩하는 염기서열을 포함하는 폴리뉴클레오티드 또는 벡터

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US (1) US20250121002A1 (https=)
EP (1) EP4372088A4 (https=)
JP (1) JPWO2023286840A1 (https=)
KR (1) KR20240034205A (https=)
CN (1) CN117795082A (https=)
AU (1) AU2022312311A1 (https=)
CA (1) CA3225682A1 (https=)
TW (1) TW202317634A (https=)
WO (1) WO2023286840A1 (https=)

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Publication number Priority date Publication date Assignee Title
US20250332195A1 (en) * 2021-07-16 2025-10-30 Noile-Immune Biotech Inc. Chimeric antigen receptor, cell expressing said receptor, pharmaceutical composition including said cell, method for producing said cell, and polynucleotide or vector including nucleotide sequence encoding said chimeric antigen receptor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2832540C (en) * 2011-04-08 2020-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer
JP6647868B2 (ja) * 2013-02-20 2020-02-14 ノバルティス アーゲー ヒト化抗ＥＧＦＲｖＩＩＩキメラ抗原受容体を用いたがんの処置
ES2857226T3 (es) * 2014-03-15 2021-09-28 Novartis Ag Receptor de antígeno quimérico regulable
WO2016016341A1 (en) * 2014-07-29 2016-02-04 Cellectis EGFRvIII SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY
TWI755547B (zh) * 2016-01-21 2022-02-21 美商輝瑞股份有限公司 靶向表皮生長因子受體變異體iii之嵌合型抗原受體
CN109219618B (zh) * 2016-01-21 2022-08-09 辉瑞大药厂 针对表皮生长因子受体变体iii和cd3的单特异性和双特异性抗体及其用途
CA3017442A1 (en) 2016-03-17 2017-09-21 Yamaguchi University Immunocompetent cell and expression vector expressing regulatory factors of immune function
CN110461881B (zh) 2017-03-27 2023-06-23 诺伊尓免疫生物科技株式会社 嵌合抗原受体
EP3753952A4 (en) * 2017-12-13 2022-04-13 XDCExplorer (Shanghai) Co., Ltd. EGFRVIII ANTIBODY AND CONJUGATE, AND METHODS FOR ITS PRODUCTION AND USE
KR101953299B1 (ko) * 2018-08-02 2019-02-28 의료법인 성광의료재단 EGFRvIII에 대한 항체 및 이의 이용

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EP4372088A4 (en) 2025-07-23
US20250121002A1 (en) 2025-04-17
EP4372088A1 (en) 2024-05-22
CN117795082A (zh) 2024-03-29
JPWO2023286840A1 (https=) 2023-01-19
CA3225682A1 (en) 2023-01-19
AU2022312311A1 (en) 2024-02-08
WO2023286840A1 (ja) 2023-01-19

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