KR20240019766A - 인터페론 유도 헬리카제 c 도메인 1(ifih1) 억제제를 이용한 건선의 치료 - Google Patents

인터페론 유도 헬리카제 c 도메인 1(ifih1) 억제제를 이용한 건선의 치료 Download PDF

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KR20240019766A
KR20240019766A KR1020237041787A KR20237041787A KR20240019766A KR 20240019766 A KR20240019766 A KR 20240019766A KR 1020237041787 A KR1020237041787 A KR 1020237041787A KR 20237041787 A KR20237041787 A KR 20237041787A KR 20240019766 A KR20240019766 A KR 20240019766A
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nucleic acid
ifih1
acid molecule
subject
trim65
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Korean (ko)
Inventor
줄리 이. 호로윗즈
마누엘 알렌 레베즈 페레이라
캐서린 시미노비치
아리스 바라스
로리 크리미안
카티아 카랄리스
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리제너론 파마슈티칼스 인코포레이티드
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Publication of KR20240019766A publication Critical patent/KR20240019766A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/04—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; involved in cellular and subcellular movement (3.6.4)
    • C12Y306/04013—RNA helicase (3.6.4.13)
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020237041787A 2021-06-10 2022-06-09 인터페론 유도 헬리카제 c 도메인 1(ifih1) 억제제를 이용한 건선의 치료 Pending KR20240019766A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163209075P 2021-06-10 2021-06-10
US63/209,075 2021-06-10
PCT/US2022/032859 WO2022261341A1 (en) 2021-06-10 2022-06-09 Treatment of psoriasis with interferon induced helicase c domain 1 (ifih1) inhibitors

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KR20240019766A true KR20240019766A (ko) 2024-02-14

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KR1020237041787A Pending KR20240019766A (ko) 2021-06-10 2022-06-09 인터페론 유도 헬리카제 c 도메인 1(ifih1) 억제제를 이용한 건선의 치료

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Country Link
US (1) US12584174B2 (https=)
EP (1) EP4352224A1 (https=)
JP (1) JP2024522148A (https=)
KR (1) KR20240019766A (https=)
CN (1) CN117441019A (https=)
AU (1) AU2022288634A1 (https=)
CA (1) CA3219620A1 (https=)
IL (1) IL308354A (https=)
MX (1) MX2023014586A (https=)
WO (1) WO2022261341A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025202219A1 (en) * 2024-03-25 2025-10-02 Institut National de la Santé et de la Recherche Médicale Mda5 inhibition as a broad defense and healthspan extending strategy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018204764A1 (en) * 2017-05-05 2018-11-08 Camp4 Therapeutics Corporation Identification and targeted modulation of gene signaling networks
BR112022006441A2 (pt) * 2019-10-04 2022-07-05 Univ Michigan Regents Métodos para determinar a capacidade de resposta à terapia antifator de necrose tumoral no tratamento da psoríase
EP3858332A1 (en) * 2020-01-31 2021-08-04 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Bottom-up assembly of synthetic extracellular vesicles

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MX2023014586A (es) 2023-12-15
US20230037582A1 (en) 2023-02-09
US12584174B2 (en) 2026-03-24
WO2022261341A1 (en) 2022-12-15
AU2022288634A9 (en) 2023-12-07
CN117441019A (zh) 2024-01-23
JP2024522148A (ja) 2024-06-11
EP4352224A1 (en) 2024-04-17
IL308354A (en) 2024-01-01
AU2022288634A1 (en) 2023-11-30
CA3219620A1 (en) 2022-12-15

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