KR20240005139A - 인간 t 세포 수용체 알파 불변 영역 유전자에 대한 특이성을 갖는 최적화된 조작된 뉴클레아제 - Google Patents
인간 t 세포 수용체 알파 불변 영역 유전자에 대한 특이성을 갖는 최적화된 조작된 뉴클레아제 Download PDFInfo
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- KR20240005139A KR20240005139A KR1020237044104A KR20237044104A KR20240005139A KR 20240005139 A KR20240005139 A KR 20240005139A KR 1020237044104 A KR1020237044104 A KR 1020237044104A KR 20237044104 A KR20237044104 A KR 20237044104A KR 20240005139 A KR20240005139 A KR 20240005139A
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862656809P | 2018-04-12 | 2018-04-12 | |
| US62/656,809 | 2018-04-12 | ||
| PCT/US2019/027019 WO2019200122A1 (en) | 2018-04-12 | 2019-04-11 | Optimized engineered nucleases having specificity for the human t cell receptor alpha constant region gene |
| KR1020207032271A KR102617818B1 (ko) | 2018-04-12 | 2019-04-11 | 인간 t 세포 수용체 알파 불변 영역 유전자에 대한 특이성을 갖는 최적화된 조작된 뉴클레아제 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207032271A Division KR102617818B1 (ko) | 2018-04-12 | 2019-04-11 | 인간 t 세포 수용체 알파 불변 영역 유전자에 대한 특이성을 갖는 최적화된 조작된 뉴클레아제 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240005139A true KR20240005139A (ko) | 2024-01-11 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237044104A Pending KR20240005139A (ko) | 2018-04-12 | 2019-04-11 | 인간 t 세포 수용체 알파 불변 영역 유전자에 대한 특이성을 갖는 최적화된 조작된 뉴클레아제 |
| KR1020207032271A Active KR102617818B1 (ko) | 2018-04-12 | 2019-04-11 | 인간 t 세포 수용체 알파 불변 영역 유전자에 대한 특이성을 갖는 최적화된 조작된 뉴클레아제 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207032271A Active KR102617818B1 (ko) | 2018-04-12 | 2019-04-11 | 인간 t 세포 수용체 알파 불변 영역 유전자에 대한 특이성을 갖는 최적화된 조작된 뉴클레아제 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11786554B2 (https=) |
| EP (2) | EP4275697A3 (https=) |
| JP (3) | JP7304888B2 (https=) |
| KR (2) | KR20240005139A (https=) |
| CN (2) | CN120249250A (https=) |
| AU (2) | AU2019252527B2 (https=) |
| CA (1) | CA3095795A1 (https=) |
| ES (1) | ES2955408T3 (https=) |
| IL (4) | IL277883B2 (https=) |
| MX (2) | MX2020010795A (https=) |
| WO (1) | WO2019200122A1 (https=) |
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| JP6816133B2 (ja) | 2015-10-05 | 2021-01-20 | プレシジョン バイオサイエンシズ,インク. | 改変ヒトt細胞受容体アルファ定常領域遺伝子を含む遺伝子改変細胞 |
| EP3359660B1 (en) | 2015-10-05 | 2019-12-04 | Precision Biosciences, Inc. | Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene |
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| EP3645038B1 (en) | 2017-06-30 | 2026-02-18 | Precision Biosciences, Inc. | Genetically-modified t cells comprising a modified intron in the t cell receptor alpha gene |
| US11786554B2 (en) * | 2018-04-12 | 2023-10-17 | Precision Biosciences, Inc. | Optimized engineered nucleases having specificity for the human T cell receptor alpha constant region gene |
| CN114026228A (zh) | 2019-05-07 | 2022-02-08 | 精密生物科学公司 | 用于识别序列的工程化大范围核酸酶的优化 |
| US20220273715A1 (en) | 2019-07-25 | 2022-09-01 | Precision Biosciences, Inc. | Compositions and methods for sequential stacking of nucleic acid sequences into a genomic locus |
| US20230183664A1 (en) | 2020-05-11 | 2023-06-15 | Precision Biosciences, Inc. | Self-limiting viral vectors encoding nucleases |
| US20250127811A1 (en) | 2021-01-28 | 2025-04-24 | Precision Biosciences, Inc. | Modulation of tgf beta signaling in genetically-modified eukaryotic cells |
| US20250064986A1 (en) | 2022-01-07 | 2025-02-27 | Precision Biosciences, Inc. | Optimized polynucleotides for protein expression |
| WO2024148167A1 (en) | 2023-01-05 | 2024-07-11 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for the human t cell receptor alpha constant region gene |
| WO2026083329A1 (en) | 2024-10-18 | 2026-04-23 | Precision Biosciences, Inc. | Methods of nuclease-initiated homology directed repair and replacement and compositions and uses thereof |
| WO2026083328A1 (en) | 2024-10-18 | 2026-04-23 | Precision Biosciences, Inc. | Base editing nucleotide sequences using homology directed repair |
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