KR20230173745A - 항-kir3dl2 작용제에 의한 치료 - Google Patents

항-kir3dl2 작용제에 의한 치료 Download PDF

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Publication number
KR20230173745A
KR20230173745A KR1020237043171A KR20237043171A KR20230173745A KR 20230173745 A KR20230173745 A KR 20230173745A KR 1020237043171 A KR1020237043171 A KR 1020237043171A KR 20237043171 A KR20237043171 A KR 20237043171A KR 20230173745 A KR20230173745 A KR 20230173745A
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KR
South Korea
Prior art keywords
kir3dl2
antibody
ser
thr
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237043171A
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English (en)
Korean (ko)
Inventor
까린 파뛰렐
엘렌 시까르
Original Assignee
이나뜨 파르마 에스.에이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이나뜨 파르마 에스.에이. filed Critical 이나뜨 파르마 에스.에이.
Publication of KR20230173745A publication Critical patent/KR20230173745A/ko
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020237043171A 2016-10-21 2017-10-19 항-kir3dl2 작용제에 의한 치료 Pending KR20230173745A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662410880P 2016-10-21 2016-10-21
US62/410,880 2016-10-21
KR1020197014069A KR20190068602A (ko) 2016-10-21 2017-10-19 항-kir3dl2 작용제에 의한 치료
PCT/EP2017/076751 WO2018073363A1 (en) 2016-10-21 2017-10-19 Treatment with anti-kir3dl2 agents

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197014069A Division KR20190068602A (ko) 2016-10-21 2017-10-19 항-kir3dl2 작용제에 의한 치료

Publications (1)

Publication Number Publication Date
KR20230173745A true KR20230173745A (ko) 2023-12-27

Family

ID=60268349

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020237043171A Pending KR20230173745A (ko) 2016-10-21 2017-10-19 항-kir3dl2 작용제에 의한 치료
KR1020197014069A Ceased KR20190068602A (ko) 2016-10-21 2017-10-19 항-kir3dl2 작용제에 의한 치료

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020197014069A Ceased KR20190068602A (ko) 2016-10-21 2017-10-19 항-kir3dl2 작용제에 의한 치료

Country Status (8)

Country Link
US (3) US20190248895A1 (https=)
EP (1) EP3529277A1 (https=)
JP (1) JP7676109B2 (https=)
KR (2) KR20230173745A (https=)
CN (1) CN109863175A (https=)
AU (1) AU2017345203B2 (https=)
CA (1) CA3037851A1 (https=)
WO (1) WO2018073363A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2682449C2 (ru) 2012-09-19 2019-03-19 Иннейт Фарма Связывающие kir3dl2 агенты
DK2958941T3 (da) 2013-02-20 2019-06-24 Innate Pharma Forbindelse, der binder specifikt til kir3dl2, til anvendelse til behandling af perifert t-cellelymfom
US10280222B2 (en) 2014-03-14 2019-05-07 Innate Pharma Humanized antibodies with increased stability
CA3125945A1 (en) * 2019-01-22 2020-07-30 Innate Pharma Treatment of t cell lymphoma
JP7716393B2 (ja) * 2019-10-04 2025-07-31 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 抗ｋｉｒ３ｄｌ３抗体およびそれらの使用

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US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
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Also Published As

Publication number Publication date
KR20190068602A (ko) 2019-06-18
EP3529277A1 (en) 2019-08-28
WO2018073363A1 (en) 2018-04-26
US20210087270A1 (en) 2021-03-25
CA3037851A1 (en) 2018-04-26
CN109863175A (zh) 2019-06-07
JP2020500161A (ja) 2020-01-09
US20240391999A1 (en) 2024-11-28
AU2017345203A1 (en) 2019-05-02
US11970535B2 (en) 2024-04-30
AU2017345203B2 (en) 2024-08-01
JP7676109B2 (ja) 2025-05-14
US20190248895A1 (en) 2019-08-15

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