KR20230159562A - 단백질 키나제 c(pkc)에서 작용하는 디테르페노이드 화합물 - Google Patents

단백질 키나제 c(pkc)에서 작용하는 디테르페노이드 화합물 Download PDF

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KR20230159562A
KR20230159562A KR1020237036087A KR20237036087A KR20230159562A KR 20230159562 A KR20230159562 A KR 20230159562A KR 1020237036087 A KR1020237036087 A KR 1020237036087A KR 20237036087 A KR20237036087 A KR 20237036087A KR 20230159562 A KR20230159562 A KR 20230159562A
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alkyl
cycloalkyl
independently
cancer
optionally substituted
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Korean (ko)
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루이홍 첸
춘 지앙
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케이-젠 테라퓨틱스, 인코포레이티드
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
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    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020237036087A 2021-03-23 2022-03-23 단백질 키나제 c(pkc)에서 작용하는 디테르페노이드 화합물 Pending KR20230159562A (ko)

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US202163164704P 2021-03-23 2021-03-23
US63/164,704 2021-03-23
PCT/US2022/021609 WO2022204327A1 (en) 2021-03-23 2022-03-23 Diterpenoid compounds that act on protein kinase c (pkc)

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EP (1) EP4313095A4 (cg-RX-API-DMAC10.html)
JP (1) JP2024512046A (cg-RX-API-DMAC10.html)
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AU (1) AU2022241774A1 (cg-RX-API-DMAC10.html)
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AU2020352641B2 (en) * 2019-09-24 2026-08-06 K-Gen Therapeutics, Inc. Diterpenoid compounds that act on protein kinase C (PKC)

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US6063814A (en) * 1997-04-14 2000-05-16 Chang; Richard L. Phorbol esters as anti-neoplastic and white blood cell elevating agents
US20070129282A1 (en) * 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
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