KR20230155422A - Egfr 및/또는 pi3k 억제제로서의 치환된 아미노벤질헤테로아릴 화합물 - Google Patents

Egfr 및/또는 pi3k 억제제로서의 치환된 아미노벤질헤테로아릴 화합물 Download PDF

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KR20230155422A
KR20230155422A KR1020237025037A KR20237025037A KR20230155422A KR 20230155422 A KR20230155422 A KR 20230155422A KR 1020237025037 A KR1020237025037 A KR 1020237025037A KR 20237025037 A KR20237025037 A KR 20237025037A KR 20230155422 A KR20230155422 A KR 20230155422A
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alkyl
compound
salt
carcinoma
cancer
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크리스토퍼 화이트헤드
주디쓰 리어폴드
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메카니스틱 테라퓨틱스 엘엘씨
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020237025037A 2020-12-22 2021-12-21 Egfr 및/또는 pi3k 억제제로서의 치환된 아미노벤질헤테로아릴 화합물 Pending KR20230155422A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063129368P 2020-12-22 2020-12-22
US63/129,368 2020-12-22
PCT/US2021/064709 WO2022140456A1 (en) 2020-12-22 2021-12-21 Substituted aminobenzyl heteroaryl compounds as egfr and/or pi3k inhibitors

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KR20230155422A true KR20230155422A (ko) 2023-11-10

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US (3) US20240239764A1 (https=)
EP (1) EP4267554A1 (https=)
JP (1) JP2024501995A (https=)
KR (1) KR20230155422A (https=)
CN (1) CN117295716A (https=)
AU (1) AU2021410726A1 (https=)
CA (1) CA3206168A1 (https=)
IL (1) IL303965A (https=)
MX (1) MX2023007550A (https=)
WO (1) WO2022140456A1 (https=)

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Publication number Priority date Publication date Assignee Title
WO2023078401A1 (en) * 2021-11-05 2023-05-11 Fochon Biosciences, Ltd. Compounds as protein kinase inhibitors
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WO2025101914A1 (en) * 2023-11-10 2025-05-15 Mekanistic Therapeutics Llc Substituted aminobenzyl heteroaryl compounds as egfr and/or pi3k inhibitors having improved therapeutic index against solid tumors

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