KR20230133294A - 화합물 또는 그 염, 및 그것들에 의해 얻어지는 항체 - Google Patents
화합물 또는 그 염, 및 그것들에 의해 얻어지는 항체 Download PDFInfo
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- KR20230133294A KR20230133294A KR1020237024074A KR20237024074A KR20230133294A KR 20230133294 A KR20230133294 A KR 20230133294A KR 1020237024074 A KR1020237024074 A KR 1020237024074A KR 20237024074 A KR20237024074 A KR 20237024074A KR 20230133294 A KR20230133294 A KR 20230133294A
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Classifications
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- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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PCT/JP2022/001358 WO2022154116A1 (ja) | 2021-01-18 | 2022-01-17 | 化合物またはその塩、およびそれらにより得られる抗体 |
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JP2016186206A (ja) | 2015-03-27 | 2016-10-27 | 義徳 川窪 | 掃除装置 |
JP2018199337A (ja) | 2018-08-23 | 2018-12-20 | ブラザー工業株式会社 | インクジェット記録装置、及びプログラム |
JP2020009165A (ja) | 2018-07-09 | 2020-01-16 | セイコーソリューションズ株式会社 | クロック調整装置及びプログラム |
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Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL106992A (en) | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Noble hydrazonic history of anthracycline and methods for their preparation |
US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
PT871490E (pt) | 1995-12-22 | 2003-07-31 | Bristol Myers Squibb Co | Ligantes de hidrazona ramificada |
EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
EP2357006B1 (en) | 2002-07-31 | 2015-09-16 | Seattle Genetics, Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
JP2006507322A (ja) | 2002-11-14 | 2006-03-02 | シンタルガ・ビーブイ | 多重自己脱離放出スペーサーとして構築されたプロドラッグ |
EP3120861B1 (en) | 2003-11-06 | 2018-08-15 | Seattle Genetics, Inc. | Intermediate for conjugate preparation comprising auristatin derivatives and a linker |
DE102004026304B3 (de) | 2004-05-28 | 2005-08-25 | Atlas Elektronik Gmbh | Prüfverfahren für ein Verfahren zur passiven Gewinnung von Zielparamentern |
JP6872181B2 (ja) | 2015-05-20 | 2021-05-19 | 国立大学法人 鹿児島大学 | IgG結合ペプチドによる抗体の特異的修飾 |
CN110637036A (zh) | 2017-04-28 | 2019-12-31 | 味之素株式会社 | 具有针对可溶性蛋白质的亲和性物质、切割性部分及反应性基团的化合物或其盐 |
WO2019240287A1 (ja) | 2018-06-14 | 2019-12-19 | 味の素株式会社 | 抗体に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩 |
EP3811978A4 (en) | 2018-06-14 | 2022-03-16 | Ajinomoto Co., Inc. | SUBSTANCE HAVING AFFINITY FOR AN ANTIBODY, AND COMPOUND OR SALT THEREOF HAVING A BIOORTHOGONAL FUNCTIONAL GROUP |
WO2020009165A1 (ja) | 2018-07-03 | 2020-01-09 | 味の素株式会社 | 修飾抗体およびその製造方法 |
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JP2020009165A (ja) | 2018-07-09 | 2020-01-16 | セイコーソリューションズ株式会社 | クロック調整装置及びプログラム |
JP2018199337A (ja) | 2018-08-23 | 2018-12-20 | ブラザー工業株式会社 | インクジェット記録装置、及びプログラム |
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