KR20230131815A - 에토포시드 토니리베이트 제제 - Google Patents
에토포시드 토니리베이트 제제 Download PDFInfo
- Publication number
- KR20230131815A KR20230131815A KR1020237009044A KR20237009044A KR20230131815A KR 20230131815 A KR20230131815 A KR 20230131815A KR 1020237009044 A KR1020237009044 A KR 1020237009044A KR 20237009044 A KR20237009044 A KR 20237009044A KR 20230131815 A KR20230131815 A KR 20230131815A
- Authority
- KR
- South Korea
- Prior art keywords
- liquid pharmaceutical
- etoposide
- infusion solution
- polysorbate
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229960005420 etoposide Drugs 0.000 title claims abstract description 89
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- FCWSQAKOPTZCOD-SQYSSJHTSA-N [4-[(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-9-yl]-2,6-dimethoxyphenyl] (2,2-dimethyl-1,3-dioxolan-4-yl)methyl carbonate Chemical compound COc1cc(cc(OC)c1OC(=O)OCC1COC(C)(C)O1)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)c2cc3OCOc3cc12 FCWSQAKOPTZCOD-SQYSSJHTSA-N 0.000 claims description 40
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
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| GBGB2012956.5A GB202012956D0 (en) | 2020-08-19 | 2020-08-19 | Etoposide toniribate formulation |
| GB2012956.5 | 2020-08-19 | ||
| GBGB2012954.0A GB202012954D0 (en) | 2020-08-19 | 2020-08-19 | Etoposide toniribate formulation |
| PCT/EP2021/073034 WO2022038226A1 (en) | 2020-08-19 | 2021-08-19 | Etoposide toniribate formulation |
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| EP4233837A1 (en) * | 2022-02-24 | 2023-08-30 | CellAct Pharma GmbH | Solid and oral etoposide toniribate compositions |
| CN116983259A (zh) * | 2023-09-27 | 2023-11-03 | 成都瑞尔医药科技有限公司 | 一种依托泊苷注射液的制备方法 |
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| JPH09507233A (ja) * | 1993-12-29 | 1997-07-22 | マトリクス ファーマスーティカル，インコーポレイティド | 細胞増殖性疾患に罹る宿主の治療方法及び治療のための組成物 |
| US6713454B1 (en) * | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
| AU2002358086B2 (en) * | 2001-12-03 | 2009-06-04 | Universitatsklinikum Charite Der Humboldt-Universitat Zu Berlin Technologie Transferstelle | Podophyllotoxins as antiproliferative agents |
| JP4020256B2 (ja) * | 2003-05-23 | 2007-12-12 | 日本化薬株式会社 | 前立腺癌の局所治療剤 |
| JP2008543789A (ja) * | 2005-06-17 | 2008-12-04 | ホスピラ オーストラリア ピーティーワイ エルティーディー | ドセタキセルの液体薬学的処方物 |
| US9889147B2 (en) * | 2010-04-16 | 2018-02-13 | Cellact Pharma Gmbh | Analogues of etoposide for the treatment of tumours |
| KR102122429B1 (ko) * | 2011-04-28 | 2020-06-12 | 온코펩타이드즈 아베 | 세포독성 디펩티드의 동결건조 제제 |
| DK2701720T3 (en) * | 2011-04-28 | 2017-10-09 | Oncopeptides Ab | Lyophilized preparation with cytotoxic dipeptides |
| GB2513299A (en) * | 2013-03-12 | 2014-10-29 | Cellact Pharma Gmbh Biomedizinzentrum | Compounds for targeting cancer stem cells |
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- 2021-08-19 CA CA3189720A patent/CA3189720A1/en active Pending
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- 2021-08-19 EP EP21765900.2A patent/EP4199933A1/en active Pending
- 2021-08-19 AU AU2021327164A patent/AU2021327164A1/en active Pending
- 2021-08-19 JP JP2023512354A patent/JP2023539154A/ja active Pending
- 2021-08-19 WO PCT/EP2021/073034 patent/WO2022038226A1/en not_active Ceased
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| US20230398069A1 (en) | 2023-12-14 |
| JP2023539154A (ja) | 2023-09-13 |
| WO2022038226A1 (en) | 2022-02-24 |
| EP4199933A1 (en) | 2023-06-28 |
| AU2021327164A1 (en) | 2023-03-16 |
| CA3189720A1 (en) | 2022-02-24 |
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