KR20230124663A - 4-아미노-3-(4-페녹시페닐)-1,3-디히드로-2h-이미다조[4,5-c]피리딘-2-온유도체 및 이의 염 - Google Patents

4-아미노-3-(4-페녹시페닐)-1,3-디히드로-2h-이미다조[4,5-c]피리딘-2-온유도체 및 이의 염 Download PDF

Info

Publication number
KR20230124663A
KR20230124663A KR1020237024852A KR20237024852A KR20230124663A KR 20230124663 A KR20230124663 A KR 20230124663A KR 1020237024852 A KR1020237024852 A KR 1020237024852A KR 20237024852 A KR20237024852 A KR 20237024852A KR 20230124663 A KR20230124663 A KR 20230124663A
Authority
KR
South Korea
Prior art keywords
formula
compound
salt
pure
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237024852A
Other languages
English (en)
Korean (ko)
Inventor
카트린 아라베이르
파트리샤 몰리너
사빈 보이스나드
다미앙 살라베리
세르쥬 페라드
세바스티앙 로이
Original Assignee
젠자임 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 젠자임 코포레이션 filed Critical 젠자임 코포레이션
Publication of KR20230124663A publication Critical patent/KR20230124663A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020237024852A 2020-12-23 2021-12-22 4-아미노-3-(4-페녹시페닐)-1,3-디히드로-2h-이미다조[4,5-c]피리딘-2-온유도체 및 이의 염 Pending KR20230124663A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063130010P 2020-12-23 2020-12-23
US63/130,010 2020-12-23
US202163245288P 2021-09-17 2021-09-17
US63/245,288 2021-09-17
PCT/US2021/064800 WO2022140511A1 (en) 2020-12-23 2021-12-22 4-amino-3-(4-phenoxyphenyl)-1,3- dihydro-2h-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof

Publications (1)

Publication Number Publication Date
KR20230124663A true KR20230124663A (ko) 2023-08-25

Family

ID=79730613

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237024852A Pending KR20230124663A (ko) 2020-12-23 2021-12-22 4-아미노-3-(4-페녹시페닐)-1,3-디히드로-2h-이미다조[4,5-c]피리딘-2-온유도체 및 이의 염

Country Status (12)

Country Link
US (1) US12624030B2 (enExample)
EP (1) EP4267572A1 (enExample)
JP (1) JP2024501247A (enExample)
KR (1) KR20230124663A (enExample)
CN (1) CN116710452B (enExample)
AU (1) AU2021409575B2 (enExample)
CA (1) CA3206176A1 (enExample)
CO (1) CO2023009491A2 (enExample)
IL (1) IL303834A (enExample)
MX (1) MX2023007641A (enExample)
TW (1) TW202241887A (enExample)
WO (1) WO2022140511A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3168146A1 (en) 2020-01-20 2021-07-29 Genzyme Corporation Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)
CA3201936A1 (en) 2020-12-10 2022-06-16 Minhua Chen Crystal form of tolebrutinib and preparation method thereof
IL303834A (en) 2020-12-23 2023-08-01 Genzyme Corp 4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-C]pyridin-2-one derivatives and their salts
EP4540229A1 (en) * 2022-06-14 2025-04-23 Principia Biopharma Inc. Methods of making tolebrutinib
US20260022123A1 (en) * 2022-06-22 2026-01-22 Principia Biopharma Inc. Methods of Making Modified BTK Inhibitors
AU2024214470A1 (en) 2023-02-01 2025-09-11 Principia Biopharma Inc. Methods of diagnosing and treating multiple sclerosis by detecting a biomarker in the cerebrospinal fluid

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3760984A (en) 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means
US3952741A (en) 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
WO2003037890A2 (en) 2001-11-01 2003-05-08 Icagen, Inc. Piperidines
CA2485641C (en) 2002-06-06 2010-12-14 Eisai Co., Ltd. Novel condensed imidazole derivatives
US20060045822A1 (en) 2004-09-01 2006-03-02 Board Of Regents, The University Of Texas System Plasma polymerization for encapsulating particles
AU2005284835A1 (en) 2004-09-14 2006-03-23 Novartis Vaccines And Diagnostics Inc. Imidazoquinoline compounds
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US8846697B2 (en) 2006-05-31 2014-09-30 The Regents Of The University Of California Purine analogs
EP2529621B1 (en) 2006-09-22 2016-10-05 Pharmacyclics LLC Inhibitors of bruton's tyrosine kinase
TW200911803A (en) 2007-07-16 2009-03-16 Organon Nv 6-phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives
UY32138A (es) 2008-09-25 2010-04-30 Boehringer Ingelheim Int Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables
US7741330B1 (en) 2009-10-12 2010-06-22 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
US8940725B2 (en) 2010-05-31 2015-01-27 Ono Pharmaceutical Co., Ltd. Purinone derivative
AU2012255860C1 (en) 2011-05-17 2015-12-10 Principia Biopharma Inc. Tyrosine kinase inhibitors
MX2013013331A (es) 2011-05-17 2014-10-17 Principia Biopharma Inc Derivados de azaindol como inhibidores de tirosina-cinasas.
US9073947B2 (en) 2011-06-10 2015-07-07 Merck Patent Gmbh Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
BR112014012727B1 (pt) 2011-11-29 2022-10-25 Ono Pharmaceutical Co., Ltd Cloridrato de 6-amino-9-[(3r)-1-(2-butinoil)-3-pirrolidinil]-7-(4-fenoxifenil)-7,9-di-hidro-8h-puri- 8-ona e composição farmacêutica
US8501724B1 (en) 2012-01-31 2013-08-06 Pharmacyclics, Inc. Purinone compounds as kinase inhibitors
MA37711A1 (fr) 2012-06-04 2017-05-31 Pharmacyclics Inc Formes cristallines d'un inhibiteur de tyrosine kinase de bruton
JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
CN104487441B (zh) 2012-06-18 2018-06-01 普林斯匹亚生物制药公司 有用于治疗癌症和自身免疫性疾病的可逆的共价吡咯并嘧啶或吡唑并嘧啶
SMT201900344T1 (it) 2012-09-10 2019-07-11 Principia Biopharma Inc Composti di pirazolopirimidina come inibitori di chinasi
CN102942567B (zh) 2012-11-09 2017-02-08 诸城市浩天药业有限公司 吡咯并喹啉醌的二钠盐结晶
KR20150084923A (ko) 2012-11-15 2015-07-22 파마시클릭스, 인코포레이티드 키나제 억제제로서의 피롤로피리미딘 화합물
US20140142099A1 (en) 2012-11-20 2014-05-22 Principia Biopharma Inc. Purinone Derivatives as Tyrosine Kinase Inhibitors
WO2014100065A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
ME03000B (me) 2012-12-21 2018-10-20 Plexxikon Inc Jedinjenja i metode modulacije kinaze i povezane indikacije
US9305578B1 (en) * 2013-08-01 2016-04-05 Seagate Technology Llc Magnetic element with reduced shield-to-shield spacing
SG11201605417QA (en) 2014-02-03 2016-08-30 Cadila Healthcare Ltd Heterocyclic compounds
CN107001362A (zh) 2014-10-06 2017-08-01 默克专利有限公司 用作btk抑制剂的杂芳基化合物及其用途
JP2016094368A (ja) 2014-11-14 2016-05-26 大日本住友製薬株式会社 ベンズイミダゾール化合物の新規結晶、及びその製造方法
WO2016086358A1 (en) 2014-12-02 2016-06-09 Merck Sharp & Dohme Corp. Hydroxymethyl piperidine orexin receptor antagonists
KR20170105021A (ko) 2015-01-28 2017-09-18 아스테라스 세이야쿠 가부시키가이샤 피라진카르복사마이드 화합물의 제조 방법 및 그 합성 중간체
EP3912979B1 (en) 2015-06-03 2026-03-25 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN105753863B (zh) 2015-09-11 2018-07-31 东莞市真兴贝特医药技术有限公司 氧代二氢咪唑并吡啶类化合物及其应用
US10358446B2 (en) 2015-10-14 2019-07-23 Zibo Biopolar Changsheng Pharmaceutical Co., Ltd. Bruton's tyrosine kinase inhibitors
KR102780243B1 (ko) 2015-11-17 2025-03-14 메르크 파텐트 게엠베하 Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물을 사용하여 다발성 경화증을 치료하는 방법
EP3327134A1 (en) 2016-11-28 2018-05-30 Carsten Korth Method and biomarkers for in vitro diagnosis of mental disorders
US20210113568A1 (en) 2018-04-27 2021-04-22 Ono Pharmaceutical Co., Ltd. PREVENTIVE AND/OR THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASE COMPRISING COMPOUND HAVING Btk INHIBITORY ACTIVITY AS ACTIVE INGREDIENT
CA3168146A1 (en) 2020-01-20 2021-07-29 Genzyme Corporation Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)
CN115867346B (zh) 2020-06-02 2025-03-14 Gb005股份有限公司 激酶抑制剂
WO2022081512A1 (en) 2020-10-12 2022-04-21 Synubi Pharmaceuticals Llc Compositions and methods of treatment of neuroinflammatory diseases with bruton's tyrosine kinase inhibitors
CA3201936A1 (en) 2020-12-10 2022-06-16 Minhua Chen Crystal form of tolebrutinib and preparation method thereof
IL303834A (en) 2020-12-23 2023-08-01 Genzyme Corp 4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-C]pyridin-2-one derivatives and their salts
CN117295735B (zh) 2021-04-23 2026-05-12 杭州领业医药科技有限公司 Tolebrutinib晶型、无定型及其制备方法和用途
CN117412749A (zh) 2021-05-21 2024-01-16 杭州领业医药科技有限公司 Tolebrutinib盐及其晶型、其制备方法、其药物组合物和用途
WO2022257845A1 (zh) 2021-06-11 2022-12-15 苏州科睿思制药有限公司 Tolebrutinib的晶型及其制备方法和用途
IL310975A (en) 2021-09-03 2024-04-01 Novartis Ag LOU064 for the treatment of multiple sclerosis
CA3241687A1 (en) 2021-12-21 2023-06-29 Tim Owens Crystalline forms of (r)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1h-imidazo[4,5-c]pyridin-2(3h)-one and salts thereof
CN119212708A (zh) 2022-05-13 2024-12-27 普林斯匹亚生物制药公司 用于髓鞘少突胶质细胞糖蛋白抗体疾病(mogad)的治疗性酪氨酸激酶抑制剂
EP4540229A1 (en) 2022-06-14 2025-04-23 Principia Biopharma Inc. Methods of making tolebrutinib
US20260022123A1 (en) 2022-06-22 2026-01-22 Principia Biopharma Inc. Methods of Making Modified BTK Inhibitors
CA3260159A1 (en) 2022-06-30 2024-01-04 Principia Biopharma Inc. Therapeutic Tyrosine Kinase Inhibitors for the Treatment of Multiple Sclerosis and Myasthenia Gravis
US20240173313A1 (en) 2022-10-11 2024-05-30 Genzyme Corporation Therapeutic tyrosine kinase inhibitors for multiple sclerosis
US20240238267A1 (en) 2022-12-20 2024-07-18 Genzyme Corporation Drug formulations of (r)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1h-imidazo[4,5-c]pyridin-2(3h)-one
AU2024214470A1 (en) 2023-02-01 2025-09-11 Principia Biopharma Inc. Methods of diagnosing and treating multiple sclerosis by detecting a biomarker in the cerebrospinal fluid
US20250282777A1 (en) 2024-03-06 2025-09-11 Principia Biopharma Inc. Methods of Making Tolebrutinib
WO2026050513A1 (en) 2024-08-30 2026-03-05 Principia Biopharma Inc. Tolebrutinib for multiple sclerosis
US20260060974A1 (en) 2024-08-30 2026-03-05 Principia Biopharma Inc. Therapeutic tyrosine kinase inhibitors for multiple sclerosis

Also Published As

Publication number Publication date
CN116710452A (zh) 2023-09-05
MX2023007641A (es) 2023-07-07
AU2021409575B2 (en) 2026-06-04
AU2021409575A1 (en) 2023-08-10
US20240051955A1 (en) 2024-02-15
US12624030B2 (en) 2026-05-12
EP4267572A1 (en) 2023-11-01
CN116710452B (zh) 2026-06-05
IL303834A (en) 2023-08-01
CO2023009491A2 (es) 2023-07-31
WO2022140511A1 (en) 2022-06-30
JP2024501247A (ja) 2024-01-11
TW202241887A (zh) 2022-11-01
CA3206176A1 (en) 2022-06-30

Similar Documents

Publication Publication Date Title
US12624030B2 (en) 4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof
TWI820276B (zh) 經取代之3-((3-胺基苯基)胺基)哌啶-2,6-二酮化合物、其組合物及使用彼等之治療方法
EP2935249B1 (en) Autotaxin inhibitors
EA025276B1 (ru) (2S,3S)-3-((2-(5-ФТОР-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-ИЛ)-5-ФТОРПИРИМИДИН-4-ИЛ)АМИНО)БИЦИКЛО[2,2,2]ОКТАН-2-КАРБОНОВАЯ КИСЛОТА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ВКЛЮЧАЮЩАЯ ЕЁ, И СПОСОБЫ ПРИМЕНЕНИЯ УКАЗАННОГО СОЕДИНЕНИЯ
US9187415B2 (en) Sulfonamides as HIV protease inhibitors
TWI797111B (zh) 雙重magl及faah抑制劑
US20210171544A1 (en) Heterocyclic Compound as a Protein Kinase Inhibitor
EP4100008B1 (en) Pyrrolo [2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss
JP6739516B2 (ja) 呼吸器合胞体ウイルス阻害剤
CA3219506A1 (en) Substituted fused bicyclic macrocyclic compounds and related methods of treatment
US20170015637A1 (en) Novel heteroaryl butanoic acid derivatives
CN104203914A (zh) 作为lsd1抑制剂的(杂)芳基环丙胺化合物
TW202204338A (zh) 半胱胺酸蛋白酶抑制劑及其使用方法
CN106795137B (zh) 氮杂环丁烷基氧基苯基吡咯烷化合物
KR20240128987A (ko) Flt3의 억제제로서의 피라진 화합물
US20250353824A1 (en) 3-phenylpropylamine derivative
JP2021520388A (ja) 抗マラリア性ヘキサヒドロピリミジン類似体
JP7833486B2 (ja) 置換されるカルバメート大環状化合物および関連のある治療方法
KR20240069728A (ko) 질환의 치료를 위한 퀴나졸린 화합물
US11858919B2 (en) HDAC1,2 inhibitors
WO2017175185A1 (en) Heteroaryl butanoic acid derivatives as lta4h inhibitors
CN109422753A (zh) 一类具有抑制并降解酪氨酸蛋白激酶jak1或jak2活性的化合物
CN109476643B (zh) 作为jak抑制剂的吡唑基氨基苯并咪唑衍生物
JP7680371B2 (ja) Ａｂｈｄ１２阻害剤並びにその作製及び使用方法
CN109422751A (zh) 一类具有降解酪氨酸蛋白激酶jak3活性的化合物

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

N231 Notification of change of applicant
PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R18 Changes to party contact information recorded

Free format text: ST27 STATUS EVENT CODE: A-3-3-R10-R18-OTH-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

D21 Rejection of application intended

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D21-EXM-PE0902 (AS PROVIDED BY THE NATIONAL OFFICE)

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902