AU2021409575B2 - 4-amino-3-(4-phenoxyphenyl)-1,3- dihydro-2h-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof - Google Patents

4-amino-3-(4-phenoxyphenyl)-1,3- dihydro-2h-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof

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Publication number
AU2021409575B2
AU2021409575B2 AU2021409575A AU2021409575A AU2021409575B2 AU 2021409575 B2 AU2021409575 B2 AU 2021409575B2 AU 2021409575 A AU2021409575 A AU 2021409575A AU 2021409575 A AU2021409575 A AU 2021409575A AU 2021409575 B2 AU2021409575 B2 AU 2021409575B2
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AU
Australia
Prior art keywords
compound
formula
salt
imidazo
phenoxyphenyl
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AU2021409575A
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AU2021409575A1 (en
Inventor
Catherine ARABEYRE
Sabine BOISNARD
Patricia MOLINER
Serge Perard
Sebastien Roy
Damien SALLABERRY
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Principia Biopharma Inc
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Principia Biopharma Inc
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Assigned to PRINCIPIA BIOPHARMA INC. reassignment PRINCIPIA BIOPHARMA INC. Request for Assignment Assignors: GENZYME CORPORATION
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2021409575A 2020-12-23 2021-12-22 4-amino-3-(4-phenoxyphenyl)-1,3- dihydro-2h-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof Active AU2021409575B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063130010P 2020-12-23 2020-12-23
US63/130,010 2020-12-23
US202163245288P 2021-09-17 2021-09-17
US63/245,288 2021-09-17
PCT/US2021/064800 WO2022140511A1 (en) 2020-12-23 2021-12-22 4-amino-3-(4-phenoxyphenyl)-1,3- dihydro-2h-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof

Publications (2)

Publication Number Publication Date
AU2021409575A1 AU2021409575A1 (en) 2023-08-10
AU2021409575B2 true AU2021409575B2 (en) 2026-06-04

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AU2021409575A Active AU2021409575B2 (en) 2020-12-23 2021-12-22 4-amino-3-(4-phenoxyphenyl)-1,3- dihydro-2h-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof

Country Status (12)

Country Link
US (1) US12624030B2 (enExample)
EP (1) EP4267572A1 (enExample)
JP (1) JP2024501247A (enExample)
KR (1) KR20230124663A (enExample)
CN (1) CN116710452B (enExample)
AU (1) AU2021409575B2 (enExample)
CA (1) CA3206176A1 (enExample)
CO (1) CO2023009491A2 (enExample)
IL (1) IL303834A (enExample)
MX (1) MX2023007641A (enExample)
TW (1) TW202241887A (enExample)
WO (1) WO2022140511A1 (enExample)

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CA3168146A1 (en) 2020-01-20 2021-07-29 Genzyme Corporation Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)
CA3201936A1 (en) 2020-12-10 2022-06-16 Minhua Chen Crystal form of tolebrutinib and preparation method thereof
IL303834A (en) 2020-12-23 2023-08-01 Genzyme Corp 4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-C]pyridin-2-one derivatives and their salts
EP4540229A1 (en) * 2022-06-14 2025-04-23 Principia Biopharma Inc. Methods of making tolebrutinib
US20260022123A1 (en) * 2022-06-22 2026-01-22 Principia Biopharma Inc. Methods of Making Modified BTK Inhibitors
AU2024214470A1 (en) 2023-02-01 2025-09-11 Principia Biopharma Inc. Methods of diagnosing and treating multiple sclerosis by detecting a biomarker in the cerebrospinal fluid

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Also Published As

Publication number Publication date
CN116710452A (zh) 2023-09-05
MX2023007641A (es) 2023-07-07
AU2021409575A1 (en) 2023-08-10
US20240051955A1 (en) 2024-02-15
KR20230124663A (ko) 2023-08-25
US12624030B2 (en) 2026-05-12
EP4267572A1 (en) 2023-11-01
CN116710452B (zh) 2026-06-05
IL303834A (en) 2023-08-01
CO2023009491A2 (es) 2023-07-31
WO2022140511A1 (en) 2022-06-30
JP2024501247A (ja) 2024-01-11
TW202241887A (zh) 2022-11-01
CA3206176A1 (en) 2022-06-30

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