JP2024501247A - ４－アミノ－３－（４－フェノキシフェニル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オン誘導体およびその塩 - Google Patents

４－アミノ－３－（４－フェノキシフェニル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オン誘導体およびその塩 Download PDF

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Publication number
JP2024501247A
JP2024501247A JP2023537962A JP2023537962A JP2024501247A JP 2024501247 A JP2024501247 A JP 2024501247A JP 2023537962 A JP2023537962 A JP 2023537962A JP 2023537962 A JP2023537962 A JP 2023537962A JP 2024501247 A JP2024501247 A JP 2024501247A
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compound
formula
salt
pure
amino
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Japanese (ja)
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JP2024501247A5 (enExample
Inventor
カトリーヌ・アラベーレ
パトリシア・モリナー
サビーヌ・ボワナール
ダミアン・サッラベリー
セルジュ・ペラード
セバスチャン・ロイ
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Genzyme Corp
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Genzyme Corp
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Publication of JP2024501247A5 publication Critical patent/JP2024501247A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2023537962A 2020-12-23 2021-12-22 ４－アミノ－３－（４－フェノキシフェニル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オン誘導体およびその塩 Pending JP2024501247A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063130010P 2020-12-23 2020-12-23
US63/130,010 2020-12-23
US202163245288P 2021-09-17 2021-09-17
US63/245,288 2021-09-17
PCT/US2021/064800 WO2022140511A1 (en) 2020-12-23 2021-12-22 4-amino-3-(4-phenoxyphenyl)-1,3- dihydro-2h-imidazo[4,5-c]pyridin-2-one derivatives and salts thereof

Related Child Applications (1)

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JP2026084568A Division JP2026133576A (ja) 2020-12-23 2026-05-20 ４－アミノ－３－（４－フェノキシフェニル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オン誘導体およびその塩

Publications (2)

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JP2024501247A true JP2024501247A (ja) 2024-01-11
JP2024501247A5 JP2024501247A5 (enExample) 2025-01-06

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JP2023537962A Pending JP2024501247A (ja) 2020-12-23 2021-12-22 ４－アミノ－３－（４－フェノキシフェニル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オン誘導体およびその塩

Country Status (12)

Country Link
US (1) US12624030B2 (enExample)
EP (1) EP4267572A1 (enExample)
JP (1) JP2024501247A (enExample)
KR (1) KR20230124663A (enExample)
CN (1) CN116710452B (enExample)
AU (1) AU2021409575B2 (enExample)
CA (1) CA3206176A1 (enExample)
CO (1) CO2023009491A2 (enExample)
IL (1) IL303834A (enExample)
MX (1) MX2023007641A (enExample)
TW (1) TW202241887A (enExample)
WO (1) WO2022140511A1 (enExample)

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CA3168146A1 (en) 2020-01-20 2021-07-29 Genzyme Corporation Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)
CA3201936A1 (en) 2020-12-10 2022-06-16 Minhua Chen Crystal form of tolebrutinib and preparation method thereof
IL303834A (en) 2020-12-23 2023-08-01 Genzyme Corp 4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-C]pyridin-2-one derivatives and their salts
EP4540229A1 (en) * 2022-06-14 2025-04-23 Principia Biopharma Inc. Methods of making tolebrutinib
US20260022123A1 (en) * 2022-06-22 2026-01-22 Principia Biopharma Inc. Methods of Making Modified BTK Inhibitors
AU2024214470A1 (en) 2023-02-01 2025-09-11 Principia Biopharma Inc. Methods of diagnosing and treating multiple sclerosis by detecting a biomarker in the cerebrospinal fluid

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Also Published As

Publication number Publication date
CN116710452A (zh) 2023-09-05
MX2023007641A (es) 2023-07-07
AU2021409575B2 (en) 2026-06-04
AU2021409575A1 (en) 2023-08-10
US20240051955A1 (en) 2024-02-15
KR20230124663A (ko) 2023-08-25
US12624030B2 (en) 2026-05-12
EP4267572A1 (en) 2023-11-01
CN116710452B (zh) 2026-06-05
IL303834A (en) 2023-08-01
CO2023009491A2 (es) 2023-07-31
WO2022140511A1 (en) 2022-06-30
TW202241887A (zh) 2022-11-01
CA3206176A1 (en) 2022-06-30

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