KR20230115350A - B 세포 림프구들의 스크리닝 방법 - Google Patents

B 세포 림프구들의 스크리닝 방법 Download PDF

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Publication number
KR20230115350A
KR20230115350A KR1020237025138A KR20237025138A KR20230115350A KR 20230115350 A KR20230115350 A KR 20230115350A KR 1020237025138 A KR1020237025138 A KR 1020237025138A KR 20237025138 A KR20237025138 A KR 20237025138A KR 20230115350 A KR20230115350 A KR 20230115350A
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South Korea
Prior art keywords
cells
interest
antibody
isolation
antigen
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Korean (ko)
Inventor
민하 박
제이슨 씨 브릭스
제이슨 엠 맥퀸
라비 케이 라메나니
디나카르 하리하라수드한 치라
카이 더블유 제토
에이드리언 티 히가
마크 피 화이트
랜덜 디 주니어 로우
샤오화 왕
케빈 티 채프먼
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버클리 라잇츠, 인크.
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Publication of KR20230115350A publication Critical patent/KR20230115350A/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/289—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • G01N33/5052—Cells of the immune system involving B-cells
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    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
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    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
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  • Biotechnology (AREA)
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  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Clinical Laboratory Science (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Fluid Mechanics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
KR1020237025138A 2016-10-23 2017-10-23 B 세포 림프구들의 스크리닝 방법 Withdrawn KR20230115350A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662411690P 2016-10-23 2016-10-23
US62/411,690 2016-10-23
US201662412092P 2016-10-24 2016-10-24
US62/412,092 2016-10-24
PCT/US2017/057926 WO2018076024A2 (en) 2016-10-23 2017-10-23 Methods for screening b cell lymphocytes
KR1020197014780A KR102560201B1 (ko) 2016-10-23 2017-10-23 B 세포 림프구들의 스크리닝 방법

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