KR20230074637A - 클라우딘 발현 암 질환을 치료하기 위한 클라우딘6 또는 클라우딘18.2 및 cd3에 결합하는 이중특이적 3가 항체 - Google Patents

클라우딘 발현 암 질환을 치료하기 위한 클라우딘6 또는 클라우딘18.2 및 cd3에 결합하는 이중특이적 3가 항체 Download PDF

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KR20230074637A
KR20230074637A KR1020237017307A KR20237017307A KR20230074637A KR 20230074637 A KR20230074637 A KR 20230074637A KR 1020237017307 A KR1020237017307 A KR 1020237017307A KR 20237017307 A KR20237017307 A KR 20237017307A KR 20230074637 A KR20230074637 A KR 20230074637A
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amino acid
cancer
fragment
acid sequence
cell
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우르 사힌
크리스티안 슈타들러
레일라 피셔
아르네 젠드레츠키
오즈렘 튀게시
파브리스 리 갈
마리아 크로이츠베르그
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비온테크 에스이
아스테라스 세이야쿠 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020237017307A 2016-09-23 2017-09-20 클라우딘 발현 암 질환을 치료하기 위한 클라우딘6 또는 클라우딘18.2 및 cd3에 결합하는 이중특이적 3가 항체 Ceased KR20230074637A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EPPCT/EP2016/072688 2016-09-23
PCT/EP2016/072688 WO2018054484A1 (en) 2016-09-23 2016-09-23 Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
KR1020197008288A KR102537091B1 (ko) 2016-09-23 2017-09-20 클라우딘 발현 암 질환을 치료하기 위한 클라우딘6 또는 클라우딘18.2 및 cd3에 결합하는 이중특이적 3가 항체
PCT/EP2017/073773 WO2018054973A1 (en) 2016-09-23 2017-09-20 Bispecific trivalent antibodies binding to claudin6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases

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KR1020197008288A Division KR102537091B1 (ko) 2016-09-23 2017-09-20 클라우딘 발현 암 질환을 치료하기 위한 클라우딘6 또는 클라우딘18.2 및 cd3에 결합하는 이중특이적 3가 항체

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KR1020237017307A Ceased KR20230074637A (ko) 2016-09-23 2017-09-20 클라우딘 발현 암 질환을 치료하기 위한 클라우딘6 또는 클라우딘18.2 및 cd3에 결합하는 이중특이적 3가 항체
KR1020197008288A Active KR102537091B1 (ko) 2016-09-23 2017-09-20 클라우딘 발현 암 질환을 치료하기 위한 클라우딘6 또는 클라우딘18.2 및 cd3에 결합하는 이중특이적 3가 항체

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US (2) US11787862B2 (enExample)
EP (2) EP3515939A1 (enExample)
JP (2) JP7055794B2 (enExample)
KR (2) KR20230074637A (enExample)
CN (2) CN110023336B (enExample)
AU (3) AU2017331331B2 (enExample)
BR (1) BR112019002168A2 (enExample)
CA (1) CA3034186A1 (enExample)
IL (3) IL264233B (enExample)
MX (2) MX2019003350A (enExample)
NZ (1) NZ750132A (enExample)
SG (1) SG11201901899PA (enExample)
WO (2) WO2018054484A1 (enExample)
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