CN110023336B - 用于治疗表达密蛋白之癌症疾病的与密蛋白6或密蛋白18.2和cd3结合的双特异性三价抗体 - Google Patents

用于治疗表达密蛋白之癌症疾病的与密蛋白6或密蛋白18.2和cd3结合的双特异性三价抗体 Download PDF

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CN110023336B
CN110023336B CN201780056781.8A CN201780056781A CN110023336B CN 110023336 B CN110023336 B CN 110023336B CN 201780056781 A CN201780056781 A CN 201780056781A CN 110023336 B CN110023336 B CN 110023336B
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cancer
amino acid
binding
cell
fragment
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CN110023336A (zh
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乌尔·沙欣
克里斯蒂亚娜·斯塔德勒
莱伊拉·菲舍尔
阿尔内·詹德雷茨基
厄兹莱姆·图雷奇
法布里斯·莱加尔
玛丽亚·克罗伊茨贝格
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Debiotech SA
Astellas Pharma Inc
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Astellas Pharma Inc
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    • A—HUMAN NECESSITIES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/00—Immunoglobulins specific features
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CN201780056781.8A 2016-09-23 2017-09-20 用于治疗表达密蛋白之癌症疾病的与密蛋白6或密蛋白18.2和cd3结合的双特异性三价抗体 Active CN110023336B (zh)

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CN202410521871.1A CN118388656A (zh) 2016-09-23 2017-09-20 用于治疗表达密蛋白之癌症疾病的与密蛋白6或密蛋白18.2和cd3结合的双特异性三价抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2016/072688 2016-09-23
PCT/EP2016/072688 WO2018054484A1 (en) 2016-09-23 2016-09-23 Bispecific trivalent antibodies binding to claudin 6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases
PCT/EP2017/073773 WO2018054973A1 (en) 2016-09-23 2017-09-20 Bispecific trivalent antibodies binding to claudin6 or claudin18.2 and cd3 for treatment of claudin expressing cancer diseases

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CN202410521871.1A Division CN118388656A (zh) 2016-09-23 2017-09-20 用于治疗表达密蛋白之癌症疾病的与密蛋白6或密蛋白18.2和cd3结合的双特异性三价抗体

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CN110023336B true CN110023336B (zh) 2024-05-17

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CN202410521871.1A Pending CN118388656A (zh) 2016-09-23 2017-09-20 用于治疗表达密蛋白之癌症疾病的与密蛋白6或密蛋白18.2和cd3结合的双特异性三价抗体

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US (2) US11787862B2 (enExample)
EP (2) EP3515939A1 (enExample)
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KR (2) KR20230074637A (enExample)
CN (2) CN110023336B (enExample)
AU (3) AU2017331331B2 (enExample)
BR (1) BR112019002168A2 (enExample)
CA (1) CA3034186A1 (enExample)
IL (3) IL264233B (enExample)
MX (2) MX2019003350A (enExample)
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