KR20230060183A - Essence composition comprising culture extract of Water (and) Opuntia Humifusa Leaf and manufacturing the same and Cosmetic Essence using the same - Google Patents

Abstract

The present invention relates to an essence composition containing an aqueous extract of Opuntia humifusa stems, a producing method thereof, and a cosmetic essence using the same. More specifically, provided is the essence composition containing an aqueous extract of Opuntia humifusa stems composed of 0.1-10 parts by weight of an aqueous extract of Opuntia humifusa stems, 0.4-4 parts by weight of hyaluronic acid, 0.04-0.4 parts by weight of adenosine, 0.0002-0.002 parts by weight of lysine, and 91.6-99.15 parts by weight of purified water. According to the producing method of the aqueous extract of Opuntia humifusa stems of the present invention, essence is produced from the aqueous extract of Opuntia humifusa stems which has antioxidant and skin inflammation alleviating effects by adjusting the viscosity of Opuntia humifusa and extracting a large amount of active ingredients from Opuntia humifusa. Accordingly, the essence which is effective in improving skin brightness and moisturization and alleviating wrinkles can be easily used by various age groups.

Description

Essence composition containing a water-soluble extract of Astragalus stem, manufacturing method thereof, and cosmetic essence using the same

The present invention relates to an essence composition containing a water-soluble extract of the stem of cinnamon plant, a method for manufacturing the same, and a cosmetic essence using the same, and more particularly, by adjusting the viscosity of cinnamon plant and extracting a large amount of active ingredients of cinnamon plant, thereby providing antioxidant and skin Essence composition containing water-soluble extract of Cheonnyeoncho stem that can be easily used by various age groups effective in improving skin brightness, wrinkles, and moisturizing by preparing essence with water-soluble extract of Cheonnyeoncho stem obtained by processing Cheonnyeoncho with efficacy of improving inflammation and manufacturing thereof It relates to a method and a cosmetic essence using the same.

Due to environmental changes, particulate matter is frequently generated. It has been reported that fine dust particles can reach pores, thereby stimulating the dermal layer of the skin to generate active oxygen, eventually causing serious problems in the skin, further aggravating atopic symptoms. In response to this, fine dust protection cosmetics are growing in popularity day by day. In addition, the use of functional essences and creams that supply moisture and nutrients to the skin in a sufficiently short time and can whiten / improve wrinkles is increasing.

Existing cosmetics with a lot of oil are prone to sticking to fine dust and pollutants in the air, which can cause irritation, so essences with enhanced ingredients, fabrics, and moisturizing time are popular. In particular, essence can be used very easily by those in their 20s to 50s, and it plays a big role in exports. In particular, through essence, consumers expect moisturizing power, whitening, and anti-wrinkle efficacy.

Cheonnyeoncho (Opuntia humifusa) is a cactus family plant and is called Opuntioideae, Opuntia. It is a native cactus, and its shape resembles a palm, so it is also called a palm cactus. Stems, fruits, roots, and flowers, excluding the thorns, have excellent commercial value because they contain nutrients and pigments, and can be commercialized by taking advantage of each characteristic. In particular, Cheonnyeoncho contains various nutrients important to the human body, such as phenolic substances, flavonoids, dietary fiber, vitamin C, calcium, minerals and amino acids, complex polysaccharides, etc. Among them, dietary fiber and calcium are contained in a large amount compared to other plants. .

Studies related to Cheonnyeoncho have been conducted on the antioxidant effect of Cheonnyeoncho cactus, the antioxidant activity of the hot water extract of the stem of Cheonnyeoncho, the effect of preventing liver damage from carbon tetrachloride, the anti-atherosclerosis effect and the improvement of aerobic exercise capacity, the antibacterial activity of the stem and fruit extract of Cheonnyeoncho, and the effect on cancer cells and breast cancer cells. Growth inhibitory effects have been reported. However, pectin, a high-molecular dietary fiber, is the main component of the fruit of cheonnyeoncho, and has a viscosity composed of arabinose, galactose, xylose, galacturonic acid, and rhamnose. It is known as a high-quality food.

When water is added during extraction from the raw material or powder of Cheonnyeoncho, there is a problem of high viscosity such as injeolmi, and in order to avoid this, when simply boiling the raw material, mucous active ingredients such as pectin cannot be used properly. On the other hand, due to high viscosity, it is difficult to use the fruit itself as a food material, so it is mostly used as a dry powder. On the other hand, in order to solve the problem of high viscosity, a fermentation technology using radiation or enzymes has been introduced. The technique of lowering the viscosity through fermentation is complicated and expensive in the extraction process and formulation.

Korean Registered Patent Publication No. 1445776 Korean Patent Publication No. 2012-0010687 Korean Registered Patent Publication No. 2227915

An object of the present invention is to provide an essence composition containing a water-soluble extract of the stem of Thousand prickly pear, which can solve the problem of viscosity of Thousand prickly pear, a manufacturing method thereof, and a cosmetic essence using the same.

In addition, the present invention is to increase the utilization of active ingredients of cheonnyeoncho by adjusting the viscosity of cheonnyeoncho extract, and to provide an essence composition containing a water-soluble extract of cheonnyeoncho stem with increased skin permeability, a manufacturing method thereof, and a cosmetic essence using the same to be

In order to achieve the above object, the present invention is a cheonnyeoncho (Opuntia humifusa) stem water-soluble extract 0.1 to 10 parts by weight, hyaluronic acid 0.4 to 4 parts by weight, adenosine 0.04 to 0.4 parts by weight, lysine 0.0002 to 0.002 parts by weight, purified water 91.6 to 99.15 parts by weight Provided is an essence composition containing the water-soluble extract of the stem of Cheonnyeoncho.

The essence composition is butylene glycol, niacinamide, 1,2-hexanediol, PEG-32, betaine, castor seed oil, xanthan gum, panthenol, PEG-60 hydrogenated castor oil, caprylyl glycol Lycol, Raw Sweet Blueberry Extract, Tomato Extract, Grapefruit Extract, Green Tea Extract, Ethylhexyl Glycerin, Xylityl Glucoside, Adenosine, Disodium EDTA, Anhydroxylitol, Xylitol, Glucose, Sodium Hyaluronate, Yam Root It may contain a water-soluble extract of the stem of Cheonnyeoncho, which is composed of an extract and a spice.

The present invention comprises the steps of washing and drying the stems of the washed cheonnyeoncho (Opuntia humifusa) and then pulverizing them into small pieces; Microwave treatment of the pulverized cheonnyeoncho; Cooling the microwave-irradiated pulverized Cheonnyeoncho at room temperature and secondary pulverization; Mixing distilled water with the pulverized Cheonnyeoncho and centrifuging to prepare an extract of Cheonnyeoncho; And freeze-drying the cheonnyeoncho extract to prepare a cheonnyeoncho powder; It is possible to provide a method for producing an essence composition containing a cheonnyeoncho stem water-soluble extract comprising a.

Another object of the present invention is to provide an essence containing a water-soluble extract of the stem of Cheonnyeoncho.

According to the manufacturing method of cheonnyeoncho stem water-soluble extract according to the present invention, the viscosity of cheonnyeoncho is adjusted, a large amount of active ingredients of cheonnyeoncho are extracted, and cheonnyeoncho, which has antioxidant and skin inflammation improvement effects, has the advantage of being able to be used by processing into cosmetics. there is.

In addition, by preparing the essence with the water-soluble extract of the stem of perennial plant according to the present invention, there is an advantage that the essence effective for improving skin brightness, wrinkles and moisturizing can be easily used in various age groups.

1 is a graph showing the results of toxicity evaluation on cells of the Cheonnyeoncho extract according to the present invention in HaCaT cells.
Figure 2 is a graph showing the anthropometric results of the skin brightness of the Cheonnyeoncho extract according to the present invention.
Figure 3 is a graph showing the skin brightness improvement rate of the test group of the Cheonnyeoncho extract according to the present invention,
Figure 4 is a graph showing the control skin brightness measurement results of the Cheonnyeoncho extract according to the present invention,
Figure 5 is a graph showing the control skin brightness improvement rate of the Cheonnyeoncho extract according to the present invention,
Figure 6 is a graph comparing the change in skin brightness of the Cheonnyeoncho extract according to the present invention,
7 is a graph showing the results of measuring the wrinkle roughness of the test group of the Cheonnyeoncho extract according to the present invention;
Figure 8 is a graph showing the improvement rate of the roughness of wrinkles around the eyes of the test group of the Cheonnyeoncho extract according to the present invention,
Figure 9 is a graph showing the results of measuring the wrinkle roughness of the control group of the Cheonnyeoncho extract according to the present invention,
10 is a graph showing the improvement rate of wrinkle roughness in the control group of the Cheonnyeoncho extract according to the present invention;
11 is a graph comparing the change in roughness of wrinkles around the eyes of the Cheonnyeoncho extract according to the present invention;
Figure 12 is a graph showing the skin moisturizing measurement results of the Cheonnyeoncho extract according to the present invention,
13 is a graph showing the skin moisturizing improvement rate of the Cheonnyeoncho extract according to the present invention.

It should be noted that in the following description, only parts necessary for understanding the embodiments of the present invention are described, and descriptions of other parts will be omitted without disturbing the gist of the present invention.

The terms or words used in this specification and claims described below should not be construed as being limited to ordinary or dictionary meanings, and the inventors have appropriately used the concept of terms to describe their inventions in the best way. It should be interpreted as a meaning and concept consistent with the technical spirit of the present invention based on the principle that it can be defined in the following way. Therefore, the embodiments described in this specification and the configurations shown in the drawings are only preferred embodiments of the present invention, and do not represent all of the technical spirit of the present invention, so various equivalents that can replace them at the time of the present application. It should be understood that there may be variations and variations.

The present invention relates to an essence composition containing a water-soluble extract of the stem of Azalea, a manufacturing method thereof, and a cosmetic essence using the same.

Cheonnyeoncho (Opuntiahumifusa, Eastern prickly pear) is a cactus that can overwinter in the inland among Opuntia sp cacti native to Korea, and is distinguished from Baeknyeoncho, a cactus native to Jeju Island. The cheonnyeoncho is also called a palm cactus because the shape of the stem is similar to that of the palm. Cheonnyeoncho is a fleshy perennial plant, that is, a perennial flowering plant, and its stem is fleshy like a common cactus, and has several segments that are constricted like nodes. They are also classified according to their shape. The tibia has a tracheid duct, a vascular bundle near the epidermis, and the leaves on the new shoot are needle-like and fall off after they are fully grown as flesh. Cotyledons are lanceolate or triangular, and have the same flesh, with different perianths and bracts. In general, it is known that the cheonnyeoncho can reduce its own moisture to less than half, can overwinter without freezing even at minus 20 ° C, and can maintain vitality. Research on cheonnyeoncho has been conducted mainly on stems and fruits, especially stems, and as a result of these studies, cheonnyeoncho pulp and stems are sold as food.

The Cheonnyeoncho may preferably use the leaves, stems, fruits, and roots of Cheonnyeoncho, and the present invention uses the stem of Cheonnyeoncho.

The composition for essence according to the present invention is composed of 0.1 to 10 parts by weight of water-soluble extract of Opuntia humifusa stem, 0.4 to 4 parts by weight of hyaluronic acid, 0.04 to 0.4 parts by weight of adenosine, 0.0002 to 0.002 parts by weight of lysine, and 91.6 to 99.15 parts by weight of purified water It contains the water-soluble extract of the stem of cheonnyeoncho.

The essence composition is butylene glycol, niacinamide, 1,2-hexanediol, PEG-32, betaine, castor seed oil, xanthan gum, panthenol, PEG-60 hydrogenated castor oil, caprylyl glycol Lycol, Raw Sweet Blueberry Extract, Tomato Extract, Grapefruit Extract, Green Tea Extract, Ethylhexyl Glycerin, Xylityl Glucoside, Adenosine, Disodium EDTA, Anhydroxylitol, Xylitol, Glucose, Sodium Hyaluronate, Yam Root It contains a water-soluble extract of the stem of cheonnyeoncho, which is formulated by further including an extract and a flavoring agent.

The Cheonnyeoncho extract may be prepared according to a conventional method known in the art, that is, a conventional method for preparing a plant extract. For example, it may be prepared by methods such as cold extraction, warm extraction, thermal extraction, ultrasonic extraction, steam distillation, supercritical fluid extraction, subcritical fluid extraction, or microwave treatment. In order to carry out the extraction method, a conventional extractor, ultrasonic crusher, or fractionator may be used.

The present invention comprises the steps of washing and drying the stems of the washed cheonnyeoncho (Opuntia humifusa) and then pulverizing them into small pieces; Microwave treatment of the pulverized cheonnyeoncho; Cooling the microwave-irradiated pulverized Cheonnyeoncho at room temperature and secondary pulverization; Mixing distilled water with the pulverized Cheonnyeoncho and centrifuging to prepare an extract of Cheonnyeoncho; And freeze-drying the cheonnyeoncho extract to prepare a cheonnyeoncho powder; Extract the water-soluble extract of the stem of Cheonnyeoncho by a manufacturing method comprising a.

Since the hyaluronic acid used in the actual composition uses a 0.5% aqueous solution, the composition ratio in the above composition ratio is the composition ratio set based on 100% hyaluronic acid. In addition, liposomalized adenosine is used for adenosine to prevent precipitation.

Adenosine, along with retinol, retinyl palmitate, and polyethoxylated retinamide, is a wrinkle improvement notice ingredient from the Food and Drug Administration. This substance is an essential component of APT, which is essential for the activity of living things, and is easily absorbed into cells and synthesized in vivo. has been

Adenosine promotes DNA synthesis of skin fibroblasts, increases protein synthesis, and serves to increase cell size. Increases nucleic acid synthesis and activates protein metabolism to help maintain anti-tension of dead or degraded skin cells, improve cell function, and expand cell size to improve wrinkles due to destruction and aging of dermal cells It also gives vitality to the skin and enhances skin elasticity. It also has the advantage of high safety and plays a role in promoting collagen synthesis.

In the present invention, as well as adenosine, the stem extract of Cheonnyeoncho is included, and has a synergistic effect on wrinkle improvement.

Lysine plays an important role in maintaining the nitrogen balance in the body. It is a kind of essential amino acid and cannot be synthesized in the body, so it must be consumed through food or supplements. In particular, lysine is classified as a limiting amino acid among essential amino acids because its food content is very low.

It is abundant in animal foods, but lacking in foods other than soybeans, so Koreans, whose staple food is rice, are likely to be deficient in lysine, especially those who do not eat a lot of soybeans.

As for lysine's body function, it is an essential material for the recovery of growth tissues and all protein components such as enzymes and hormones. It also has the effect of preventing and improving osteoporosis. Lysine is needed to transport minerals to the bone. In addition, lysine inhibits the growth of viruses such as colds and herpes simplex because it inhibits the growth of the herpes virus.

Hyaluronic acid is a linear polymer in which B-D-N-acetylglucosamine and B-D-glucuronic acid are alternately bonded, and is a polysaccharide having a molecular weight of 50,000 to 10,000,000 Da or higher. Hyaluronic acid is a basic substance of biological connective tissue, mainly mammalian skin, synovial fluid of joints, vitreous humor of eyes, umbilical cord, serum, and cock's comb. It is distributed on the back and is also known to exist in the capsules of streptococci and bacilli. Common methods for obtaining hyaluronic acid include extracting from chicken combs, umbilical cords, etc., culturing streptococci and bacilli, and then extracting and refining them.

Although natural hyaluronic acid is polydisperse in proportion to its molecular weight, it is known to exhibit excellent biocompatibility when transplanted or injected into a living body regardless of its origin because it has no interspecies specificity and no tissue or organ specificity. However, when hyaluronic acid is applied naturally to the body, it is easily decomposed by an enzyme called hyaluronic acid present in the body, so the half-life in the living tissue is about 0.5 to 3 days, so the residence time in the body is relatively short, so it is used as a medical material. There are limits to what you can do. Hyaluronic acid is a major component of the dermal connective tissue matrix and exists in the form of a viscoelastic liquid that surrounds collagen and elastin fibers. Unlike collagen, the chemical structure of all species is the same, so it does not cause an immune response.

The hydrophilic nature of hyaluronic acid attracts and retains water within the extracellular matrix space, influencing tissue volume and pressure. In the case of aged skin, the amount of hyaluronic acid decreases, resulting in a loss of moisture, which eventually breaks down the collagen and elastin fibers that are characteristic of aged skin.

The composition containing the active ingredient of the present invention exhibits functions such as improving skin elasticity and anti-aging, and thus can be used in various cosmetics. The essence of the present invention may contain one or more components selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high-molecular peptides, high-molecular polysaccharides, sphingolipids, and seaweed extracts.

Any water-soluble vitamin can be used as long as it can be formulated into cosmetics, but preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H, etc. salts (thiamin hydrochloride, sodium ascorbate, etc.) or derivatives (sodium ascorbic acid-2-phosphate, magnesium salt of ascorbic acid-2-phosphate, etc.) included Water-soluble vitamins can be obtained by conventional methods such as a microbial transformation method, a purification method from a microbial culture, an enzymatic method, or a chemical synthesis method.

Any useful vitamin may be used as long as it can be formulated into cosmetics, but preferably vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (d1-alpha tocopherol, d-alpha tocopherol, d-alpha tocopherol), etc. are mentioned. , their derivatives (ascorbine palmitate, ascorbine stearate, ascorbine dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol nicotinate, vitamin E, DL-pantothenyl alcohol, D-pantothenyl alcohol, pantothenylethyl ether, etc.) and the like are also included in the useful vitamins used in the present invention. The useful vitamins can be obtained by conventional methods such as microbial transformation, purification from microbial culture, enzymatic or chemical synthesis.

Any polymeric peptide may be used as long as it can be formulated into cosmetics, but preferably collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, keratin and the like are mentioned. Polymer peptides can be purified and obtained by conventional methods such as a purification method from a culture medium of microorganisms, an enzyme method, or a chemical synthesis method, or can be used after being purified from natural products such as pig or cow dermis or silkworm silk fibers.

Any polymeric polysaccharide may be used as long as it can be incorporated into cosmetics, but hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfate or a salt thereof (sodium salt or the like) is preferable. For example, chondroitin sulfate or a salt thereof can be used after being purified from mammals or fish.

In addition to the above essential components, the essence of the present invention may contain other components normally formulated in cosmetic products, if necessary. Other ingredients that may be added include fats and oils, humectants, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, A blood circulation accelerator, a cooling agent, an antiperspirant, purified water, etc. are mentioned. Examples of the oil and fat component include ester oils, hydrocarbon oils, silicone oils, fluorine oils, animal fats and vegetable oils.

As ester-based fats and oils, triglyceryl 2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearate isocetyl, stearic acid Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoalkyl neopentanoate, tri(capryl, capric acid) glyceryl, trimethylolpropane tri2-ethylhexanoate, trimethylolpropane triisostearate, pentaelislitol tetra2-ethylhexanoate , Cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinooleate, isostea laurate Lil, isotridecyl myristate, isocetyl palmitate, octyl stearate, isocetyl stearate, isocetyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, 2-ethylhexanoate Aryl, 2-ethyl stearyl hexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprate, di(caprylic, capric acid) propylene glycol, propylene glycol dicaprylate, dicap Neopentyl glycol prinate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isostea octanoate Lil, octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleate, polyglycerin isostearate , triisocetyl citrate, triisoalkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, horse Diisostearyl acid, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate , cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phyteryl isostearate, physteryl oleate, 12-stealoylisocetyl hydroxystearate, 12-stealo and esters such as stearyl ylhydroxystearate and isostearyl 12-stealoylhydroxystearate.

Animal or vegetable oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, birdflower oil, soybean oil, corn oil, rapeseed oil, algae oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil , cottonseed oil, palm oil, kukui nut oil, wheat germ oil, rice germ oil, shea butter, moonshine colostrum, marker damian nut oil, meadowsweet oil, egg yolk oil, beef tallow, horse oil, mink oil, orange raffia oil, jojoba oil , animal or plant fats and oils such as candelilla wax, carnaba wax, liquid lanolin, and hydrogenated castor oil.

Examples of the moisturizer include water-soluble low-molecular moisturizers, fat-soluble molecular moisturizers, water-soluble polymers, and oil-soluble polymers.

Examples of water-soluble low-molecular moisturizers include serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene Glycol (polymerization degree n = 2 or more), polyglycerol B (polymerization degree n = 2 or more), lactic acid, lactate, etc. are mentioned.

Cholesterol, cholesterol ester, etc. are mentioned as a fat-soluble low-molecular moisturizer.

Examples of water-soluble polymers include carboxyvinyl polymer, polyaspartate, tragacanth, xanthan gum, methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, water-soluble chitin, chitosan, dextrin, and the like. can

Examples of the fat-soluble polymers include polyvinylpyrrolidone and eicosene copolymers, polyvinylpyrrolidone and hexadecene copolymers, nitrocellulose, dextrin fatty acid esters, and high-molecular silicones. Examples of the emollient agent include long-chain acyl glutamic acid cholesteryl ester, hydroxystearic acid cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid, and lanolin fatty acid cholesteryl ester.

Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants.

Nonionic surfactants include self-emulsifying glycerin monostearate, propylene glycol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, POE (polyoxyethylene) sorbitan fatty acid esters, POE sorbitan fatty acid esters, POE Glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hydrogenated castor oil, POE castor oil, POE and POP (polyoxyethylene and polyoxypropylene) copolymer, POE and POP alkyl ether, polyether modified silicone, lauric acid alkanolamides, alkylamine oxides, hydrogenated soybean phospholipids, and the like.

Anionic surfactants include fatty acid soaps, alpha-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, POE alkyl ether sulfates, alkyl amide sulfates, alkyl phosphates, POE alkyl phosphates, alkyl amides. Phosphates, alkyloylalkyl taurine salts, N-acylamino acid salts, POE alkyl ether carboxylates, alkyl sulfosuccinates, sodium alkyl sulfoacetates, acylated hydrolyzed collagen peptide salts, perfluoroalkyl phosphate esters, and the like. there is.

As the cationic surfactant, alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, chloride Benzalkonium, diethylaminoethyl stearate, dimethylaminopropyl stearate, quaternary ammonium salts of lanolin derivatives, and the like. Amphoteric surfactants include carboxybetaine type, amidebetaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amideamine type, etc. An amphoteric surfactant etc. are mentioned.

As organic and inorganic pigments, silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium-coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, aluminum oxide inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine blue, chromium oxide, chromium hydroxide, calamine and complexes thereof; polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenolic resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene and styrene copolymers, organic pigments such as silk powder, cellulose, CI pigment yellow and CI pigment orange, and composite pigments of these inorganic pigments and organic pigments.

Examples of the organic powder include metal soaps such as calcium stearate; Alkyl phosphate metal salts, such as zinc sodium cetylrate, zinc laurylate, and calcium laurylate; polyvalent metal salts of acyl amino acids such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroyl glycine calcium; polyvalent metal salts of amide sulfonic acids such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N-epsilon-lauroyl-L-lysine, N-epsilon-palmitoylizine, N-alpha-paritoylolnithine, N-alpha-lauroylarginine, N-alpha-hardened beef fatty acid acylarginine, etc. -acyl basic amino acids; N-acyl polypeptides such as N-lauroyl glycyl glycine; alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene and styrene copolymers, tetrafluoroethylene, and the like.

Examples of UV absorbers include para-aminobenzoic acid, ethyl para-aminobenzoate, amyl para-aminobenzoate, octyl para-aminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicylate, butylphenyl salicylate, homomenthyl salicylate, and benzyl cinnamate. , paramethoxycinnamic acid-2-ethoxyethyl, paramethoxycinnamic acid octyl, diparamethoxycinnamic acid mono-2-ethylhexane glyceryl, paramethoxycinnamic acid isopropyl, diisopropyl and diisopropylcinnamic acid ester mixture, Urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone disulfonic acid sodium, dihydroxybenzoate Phenone, tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)- 1,3,5-triazine, 2-(2-hydroxy-5-methylphenyl)benzotriazole, etc. are mentioned.

Bactericides include hinokitiol, triclosan, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zincophylthione, benzalkonium chloride, photosensitizer So No. 301, mononitroguacol sodium, undecyrenic acid, etc. are mentioned.

Examples of antioxidants include butylhydroxyanisole, propyl gallic acid, and elisorbic acid.

Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, fumaric acid, sodium fumalate, succinic acid, sodium succinate, sodium hydroxide, and sodium monohydrogenphosphate.

Examples of alcohol include higher alcohols such as cetyl alcohol.

In addition, the blending components that may be added other than these are not limited thereto, and any of the above components can be blended within a range not impairing the objects and effects of the present invention.

The essence of the present invention may take the form of a solution, emulsion, viscous mixture or the like.

Ingredients included in the essence of the present invention may include ingredients commonly used in essence as active ingredients, and include, for example, stabilizers, solubilizers, vitamins, pigments, and conventional auxiliary agents such as flavoring agents and carriers. .

The essence of the present invention can be prepared in any formulation commonly produced in the art, and examples thereof include emulsion, cream, lotion, pack, foundation, lotion, beauty essence, hair cosmetics, and the like.

Essence according to the present invention contains a thousand prickly pear extract as an active ingredient, and may additionally include functional substances for antioxidant activity and skin inflammation improvement, or substances such as excipients and diluents for improving physical properties. The functional material or material for improving physical properties may be added within the range of maintaining the effect of the present invention.

For example, when the formulation of the present invention is a spray, lactose, talc, silica, aluminum hydroxide, and calcium silicate may be used as carrier components. In particular, when the formulation of the present invention is a spray, additionally chlorofluorohydrocarbon , propellants such as propane/butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solvating agent, or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, 1,3 -It may be a fatty acid ester of butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

A functional essence with antioxidant activity and skin cell regeneration ability containing the ethyl acetate fraction of the methanol extract of Opintia humifusa stems with antioxidant activity and skin fibroblast regeneration ability as an active ingredient, using the methanol extract of the stems of Opintia humifusa The ethyl acetate fraction is remarkably superior in antioxidant activity and skin fibroblast regeneration ability compared to those using other solvents or other parts, and thus has excellent antioxidant function. 1 is a graph showing the results of toxicity evaluation on cells of the Cheonnyeoncho extract according to the present invention in HaCaT cells. As shown in FIG. 1, it was confirmed that the survival rate was higher as well as the reduction in toxicity during the evaluation of cytotoxicity.

The essence of the present invention has excellent moisturizing power and excellent skin soothing effect.

However, since it is not possible to improve the viscosity of cheonnyeoncho itself, it is possible to adjust the viscosity through nanoization by irradiating microwaves in order to extract the active ingredient through the stem extract of cheonnyeoncho and apply it to cosmetics. Through this, the delivery rate of the skin through the extraction of abundant active ingredients of cheonnyeoncho itself, formulation of cosmetics, and nanoparticles is improved.

Another embodiment of the present invention provides an essence containing the Cheonnyeoncho extract of the present invention.

This is the result of a human application test on the improvement of skin brightness, wrinkles, and moisturizing of the essence containing the water-soluble extract of the stem of Astragalus persimmon according to the present invention. The above test site was the face, and a human application test was conducted on 21 healthy adult men and women aged 20 to 60 years old.

First, skin brightness and wrinkles were evaluated before product use, after 4 weeks of product use, after 8 weeks of product use, and after 12 weeks of product use, respectively. Skin moisturizing was evaluated before and after product use. As a measuring method, the measuring devices were Corneometer (Courage+Khazaka electronic GmbH, Germany), Spectrophotomter (Konica Minolta), and PRIMOS CR (CANFIELD), and the measurement results and questionnaire evaluation results of the devices were analyzed.

Skin brightness was measured at the same location on the face using a spectrophotometer (CM-26D), and changes were compared and evaluated before product use, after 4 weeks of product use, after 8 weeks of product use, and after 12 weeks of product use. and the control group were compared and compared between groups. The improvement rate was calculated as follows.

*n: 4,8,12

It was analyzed using SPSSS statistics of the data solution, and the test results were subjected to statistical analysis after the normality test was performed. As a result of the analysis, when the significance probability p<0.05 in the 95% confidence interval, it was judged that there was an improvement effect by using the test product. did For statistical analysis, paired samples t-test was used when the parametric method was used, and Wilcoxon signed rank test was used when the non-parametric method was used. Independent samples t-test was used when the parametric method was used. In the case of using a non-parametric method, it was analyzed using the Mann-Whitney U test.

In the before-and-after comparison of skin brightness, the skin brightness (L*value) measurement results of the test group were 59.55 A.U. before product use, 60.22 A.U. after 4 weeks of product use, 59.94 A.U. after 8 weeks of product use, and 12 after product use, as shown in FIG. After a week, the measured value increased at a statistically significant level to 60.22 A.U., and as shown in Figure 3, the skin brightness improvement rate in the test group was 1.50% after 4 weeks of product use, 0.96% after 8 weeks of product use, and 0.96% after 8 weeks of product use, compared to before product use. After 12 weeks, an improvement rate of 1.39% was shown (p<0.05).

As a result of measuring skin brightness (L*value) of the control group, as shown in FIG. 4, 58.65 A.U. before product use, 59.86 A.U. after 4 weeks of product use, 58.70 A.U. after 8 weeks of product use, and 58.79 A.U. after 12 weeks of product use. The measured value increased at a statistically significant level only after 2 weeks (p<0.05), and as shown in Figure 5, the skin brightness improvement rate in the control group was 239% after 4 weeks of product use, 0.10% after 8 weeks of product use, compared to before product use. After 12 weeks of using the product, an improvement rate of 0.28% was shown.

In the comparison of skin brightness between the test group and the control group, the test group showed a statistically significant increase in skin brightness after 4 weeks of product use, 8 weeks of product use, and 12 weeks of product use compared to before product use (p <0.05), the control group showed a statistically significant increase in skin brightness only after 4 weeks of product use compared to before product use (p<0.05).

Figure 6 shows the comparison results of skin brightness change (Δ) after 12 weeks of product use compared to before product use in the test group and control group. As shown in FIG. 6, the change amount (Δ) of the test group was 082, and the change amount (Δ) of the control group was 016, showing a statistically significant difference (p<0.05).

Next, the results of the human application test of the roughness of wrinkles around the eyes are shown.

The roughness of the same location on the face was measured using Primos CR (CANFIELD), and the changes in roughness were compared and evaluated before product use, after 4 weeks of use, after 8 weeks of product use, and after 12 weeks of product use, and the test group and control group were compared. and compared between groups

The improvement rate was calculated as follows.

*n: 4,8,12

Comparing before and after use of the essence according to the present invention, as a result of measuring the wrinkle roughness (Ra) of the test group, 19.529 A.U. before product use, 18.465 A.U. after 4 weeks of product use, 16.528 A.U. after 8 weeks of product use, After 12 weeks of product use, the measured value decreased to a statistically significant level after 8 weeks and 12 weeks of product use, with 16.342 A.U. after 12 weeks of product use. 3.02%, 13.20% after 8 weeks of product use, and 15.04% after 12 weeks of product use (p<0.05).

On the other hand, as a result of measuring the wrinkle roughness (Ra) of the control group in FIG. 9, 19.194 A.U. before product use, 18.6858 A.U. after 4 weeks of product use, 17.952 A.U. after 8 weeks of product use, and 17.11 A.U. after 12 weeks of product use, statistically significant after 12 weeks of product use. , the measured value decreased to a significant level, and looking at the improvement rate of the wrinkle roughness of the control group shown in FIG. 10, 1.38% after 4 weeks of product use, 4.29% after 8 weeks of product use, and 8.82% after 12 weeks of product use compared to before product use showed an improvement rate (p<0.05).

In the group comparison between the test group and the control group of the roughness of the wrinkles around the eyes, the test group showed a statistically significant reduction in the roughness of the wrinkles around the eyes after 8 weeks and 12 weeks of product use compared to before product use (p<0.05), The control group showed a statistically significant reduction in the roughness of wrinkles around the eyes only after 12 weeks of product use compared to before product use (p<0.05).

As a result of comparing the change in roughness (Δ) of the test group and the control group after using the product compared to before using the product, as shown in FIG. However, there was no statistical significance in the test group compared to the control group (p>0.05).

For skin moisturizing, the moisture content of the skin at the same location on the face was measured using a Corneometer, and the change in moisture content before and after product use was compared and evaluated.

The improvement rate was calculated as follows.

In the skin moisturizing improvement test, as a result of measuring the skin moisture content of the test group as a result of comparison before and after, as shown in FIG. 12, 35.1 A.U. before product use and 84.9 A.U. immediately after product use. The measured value increased at a statistically significant level, and the skin moisturizing improvement rate shown in FIG. 13 showed an improvement rate of 147.58% immediately after using the product compared to before using the product (p <0.05).

From the results of the human body application test, it was confirmed that the essence of the present invention helps improve skin brightness, wrinkles, and moisturizing.

Claims (4)

Opuntia humifusa stem water-soluble extract 0.1 ~ 10 parts by weight, hyaluronic acid 0.4 ~ 4 parts by weight, adenosine 0.04 ~ 0.4 parts by weight, lysine 0.0002 ~ 0.002 parts by weight, Essence composition containing Opuntia humifusa stem water-soluble extract composed of the remaining amount of purified water . According to claim 1,
Butylene Glycol, Niacinamide, 1,2-Hexanediol, PEG-32, Betaine, Castor Seed Oil, Xanthan Gum, Panthenol, PEG-60 Hydrogenated Castor Oil, Caprylyl Glycol, Raw Sweet blueberry extract, tomato extract, grapefruit extract, green tea extract, ethylhexylglycerin, xylityl glucoside, adenosine, disodium EDTA, anhydroxylitol, xylitol, glucose, sodium hyaluronate, yam root extract, fragrance Essence composition containing a water-soluble extract of cheonnyeoncho stem further comprising. Washing and drying the stems of the washed Opuntia humifusa and grinding them into small pieces;
Microwave treatment of the pulverized cheonnyeoncho;
Cooling the microwave-irradiated pulverized Cheonnyeoncho at room temperature and secondary pulverization;
Mixing distilled water with the pulverized Cheonnyeoncho and centrifuging to prepare an extract of Cheonnyeoncho; and
Freezing the cheonnyeoncho extract to prepare a cheonnyeoncho powder;
A method for producing an essence composition containing a water-soluble extract of Cheonnyeoncho stem comprising a. Essence containing the water-soluble extract of the stem of Cheonnyeoncho according to claim 1.

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