KR20230042032A - Brm 분해의 항체 접합 화학 유도제 및 이의 방법 - Google Patents

Brm 분해의 항체 접합 화학 유도제 및 이의 방법 Download PDF

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Publication number
KR20230042032A
KR20230042032A KR1020237003871A KR20237003871A KR20230042032A KR 20230042032 A KR20230042032 A KR 20230042032A KR 1020237003871 A KR1020237003871 A KR 1020237003871A KR 20237003871 A KR20237003871 A KR 20237003871A KR 20230042032 A KR20230042032 A KR 20230042032A
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South Korea
Prior art keywords
conjugate
antibody
cide
brm
e3lb
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Pending
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KR1020237003871A
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English (en)
Korean (ko)
Inventor
피터 스코트 드라고비치
섬머 에이. 베이커 도크리
토마스 하든 필로우
동루 장
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제넨테크, 인크.
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Publication of KR20230042032A publication Critical patent/KR20230042032A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020237003871A 2020-07-21 2021-07-20 Brm 분해의 항체 접합 화학 유도제 및 이의 방법 Pending KR20230042032A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063054757P 2020-07-21 2020-07-21
US63/054,757 2020-07-21
PCT/US2021/042280 WO2022020288A1 (en) 2020-07-21 2021-07-20 Antibody-conjugated chemical inducers of degradation of brm and methods thereof

Publications (1)

Publication Number Publication Date
KR20230042032A true KR20230042032A (ko) 2023-03-27

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KR1020237003871A Pending KR20230042032A (ko) 2020-07-21 2021-07-20 Brm 분해의 항체 접합 화학 유도제 및 이의 방법

Country Status (18)

Country Link
US (1) US20230330249A1 (enExample)
EP (1) EP4185328A1 (enExample)
JP (1) JP2023535409A (enExample)
KR (1) KR20230042032A (enExample)
CN (1) CN116249556A (enExample)
AR (1) AR123019A1 (enExample)
AU (1) AU2021312225A1 (enExample)
BR (1) BR112023001143A2 (enExample)
CA (1) CA3188649A1 (enExample)
CL (2) CL2023000193A1 (enExample)
CO (1) CO2023000679A2 (enExample)
CR (1) CR20230017A (enExample)
IL (1) IL299860A (enExample)
MX (1) MX2023000888A (enExample)
PE (1) PE20231104A1 (enExample)
PH (1) PH12023550129A1 (enExample)
TW (1) TW202216215A (enExample)
WO (1) WO2022020288A1 (enExample)

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US12606568B2 (en) 2020-12-09 2026-04-21 Kymera Therapeutics, Inc. SMARCA degraders and uses thereof
JP2024533990A (ja) * 2021-08-09 2024-09-18 ジェネンテック， インコーポレイテッド Ｂｒｍの調節に使用するためのフェノール誘導体
AR128331A1 (es) * 2022-01-26 2024-04-17 Genentech Inc Inductores químicos de degradación conjugados con anticuerpos y métodos de estos
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WO2023216009A1 (zh) * 2022-05-07 2023-11-16 哈尔滨工业大学 一种小分子—纳米抗体偶联物临近效应的snacip诱导剂及其制备方法与应用
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WO2026076250A1 (en) * 2024-10-03 2026-04-09 Genentech, Inc. Lipid nanoparticles for delivery to the cns from systemic administration

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TW202216215A (zh) 2022-05-01
CA3188649A1 (en) 2022-01-27
JP2023535409A (ja) 2023-08-17
CR20230017A (es) 2023-02-17
CO2023000679A2 (es) 2023-01-26
MX2023000888A (es) 2023-02-22
CL2023003166A1 (es) 2024-05-03
EP4185328A1 (en) 2023-05-31
IL299860A (en) 2023-03-01
US20230330249A1 (en) 2023-10-19
BR112023001143A2 (pt) 2023-02-14
AR123019A1 (es) 2022-10-26
PH12023550129A1 (en) 2024-06-24
WO2022020288A1 (en) 2022-01-27
AU2021312225A1 (en) 2023-02-16
CN116249556A (zh) 2023-06-09
PE20231104A1 (es) 2023-07-19
CL2023000193A1 (es) 2023-07-28

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Patent event code: PA02012R01D

Patent event date: 20240719

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