KR20230013266A - 올리고뉴클레오티드 - Google Patents
올리고뉴클레오티드 Download PDFInfo
- Publication number
- KR20230013266A KR20230013266A KR1020227044467A KR20227044467A KR20230013266A KR 20230013266 A KR20230013266 A KR 20230013266A KR 1020227044467 A KR1020227044467 A KR 1020227044467A KR 20227044467 A KR20227044467 A KR 20227044467A KR 20230013266 A KR20230013266 A KR 20230013266A
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- oligonucleotide
- bases
- modified
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12N2310/11—Antisense
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- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/17—Immunomodulatory nucleic acids
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2020901606 | 2020-05-19 | ||
| AU2020901606A AU2020901606A0 (en) | 2020-05-19 | Oligonucleotides | |
| PCT/AU2021/050469 WO2021232099A1 (en) | 2020-05-19 | 2021-05-19 | Oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230013266A true KR20230013266A (ko) | 2023-01-26 |
Family
ID=78708815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227044467A Pending KR20230013266A (ko) | 2020-05-19 | 2021-05-19 | 올리고뉴클레오티드 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20230348903A1 (https=) |
| EP (1) | EP4153751A4 (https=) |
| JP (1) | JP2023526090A (https=) |
| KR (1) | KR20230013266A (https=) |
| CN (1) | CN115916978A (https=) |
| AU (1) | AU2021276730A1 (https=) |
| BR (1) | BR112022023310A2 (https=) |
| CA (1) | CA3171986A1 (https=) |
| MX (1) | MX2022014495A (https=) |
| WO (1) | WO2021232099A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115916978A (zh) | 2020-05-19 | 2023-04-04 | 哈德森医学研究所 | 寡核苷酸 |
| US20240384268A1 (en) * | 2021-04-08 | 2024-11-21 | Hudson Institute of Medical Research | Oligonucleotides |
| CN118460654B (zh) * | 2024-07-10 | 2025-02-14 | 凯莱英医药集团(天津)股份有限公司 | 一种Givosiran的制备方法 |
| CN119592567B (zh) * | 2024-12-10 | 2025-12-02 | 浙江大学 | 基于肿瘤剪接转换治疗的反义寡核苷酸及其应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6320041B1 (en) | 2001-04-13 | 2001-11-20 | Trilink Biotechnologies, Inc. | Pre-activated carbonyl linkers for the modification of oligonucleotides |
| US8153141B2 (en) | 2002-04-04 | 2012-04-10 | Coley Pharmaceutical Gmbh | Immunostimulatory G, U-containing oligoribonucleotides |
| US20050239733A1 (en) | 2003-10-31 | 2005-10-27 | Coley Pharmaceutical Gmbh | Sequence requirements for inhibitory oligonucleotides |
| WO2005097993A2 (en) * | 2004-02-19 | 2005-10-20 | Coley Pharmaceutical Group, Inc. | Immunostimulatory viral rna oligonucleotides |
| WO2006063152A2 (en) * | 2004-12-08 | 2006-06-15 | 3M Innovative Properties Company | Immunostimulatory combinations and methods |
| EP1819365B1 (en) | 2004-12-09 | 2014-07-02 | Alnylam Pharmaceuticals Inc. | Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs |
| CN101160401A (zh) * | 2005-02-24 | 2008-04-09 | 科勒制药集团公司 | 免疫刺激寡核苷酸 |
| EP1764107A1 (en) * | 2005-09-14 | 2007-03-21 | Gunther Hartmann | Compositions comprising immunostimulatory RNA oligonucleotides and methods for producing said RNA oligonucleotides |
| US8076068B2 (en) | 2005-09-14 | 2011-12-13 | Gunther Hartmann | Method for determining immunostimulatory activity of RNA oligonucleotides |
| KR20080059595A (ko) * | 2005-09-27 | 2008-06-30 | 콜리 파마슈티칼 게엠베하 | 어댑터 올리고뉴클레오티드를 사용하는 tlr-매개 면역반응의 조절 |
| PL1957647T3 (pl) * | 2005-11-25 | 2015-07-31 | Zoetis Belgium S A | Oligorybonukleotydy immunostymulujące |
| CN101331229B (zh) * | 2005-11-25 | 2012-08-29 | 科勒制药股份公司 | 免疫刺激性寡核糖核苷酸 |
| EP2021008B1 (en) * | 2006-04-07 | 2015-12-02 | Idera Pharmaceuticals, Inc. | Stabilized immune modulatory rna (simra) compounds for tlr7 and tlr8 |
| AU2007268075C1 (en) | 2006-06-01 | 2013-03-07 | Trilink Biotechnologies | Chemically modified oligonucleotide primers for nucleic acid amplification |
| AU2007280690C1 (en) * | 2006-07-31 | 2012-08-23 | Curevac Gmbh | Nucleic acid of formula (I): GIXmGn, or (II): CIXmCn, in particular as an immune-stimulating agent/adjuvant |
| EP3342415B1 (en) * | 2006-08-08 | 2022-01-26 | Rheinische Friedrich-Wilhelms-Universität Bonn | Structure and use of 5' phosphate oligonucleotides |
| WO2008019486A1 (en) | 2006-08-16 | 2008-02-21 | Protiva Biotherapeutics, Inc. | Nucleic acid modulation of toll-like receptor-mediated immune stimulation |
| CA2692161C (en) * | 2007-07-09 | 2015-09-29 | Idera Pharmaceuticals, Inc. | Stabilized immune modulatory rna (simra) compounds |
| JP5753382B2 (ja) * | 2007-11-06 | 2015-07-22 | アディウティーダ ファーマシューティカルズ ゲーエムベーハー | 修飾されたオリゴリン酸基を含有する免疫賦活オリゴリボヌクレオチドアナログ |
| US20100047188A1 (en) * | 2008-08-04 | 2010-02-25 | Idera Pharmaceuticals, Inc. | Modulation of toll-like receptor 8 expression by antisense oligonucleotides |
| US9631227B2 (en) | 2009-07-06 | 2017-04-25 | Trilink Biotechnologies, Inc. | Chemically modified ligase cofactors, donors and acceptors |
| EP3191591A1 (en) * | 2014-09-12 | 2017-07-19 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting complement component c5 and methods of use thereof |
| WO2016205323A1 (en) * | 2015-06-18 | 2016-12-22 | Alnylam Pharmaceuticals, Inc. | Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof |
| ES2964690T3 (es) | 2015-09-21 | 2024-04-09 | Trilink Biotechnologies Llc | Método para sintetizar ARN con caperuza 5' |
| WO2017100587A1 (en) * | 2015-12-09 | 2017-06-15 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting programmed cell death 1 ligand 1 (pd-l1) and methods of use thereof |
| WO2018184003A1 (en) | 2017-03-31 | 2018-10-04 | Dana-Farber Cancer Institute, Inc. | Modulating dsrna editing, sensing, and metabolism to increase tumor immunity and improve the efficacy of cancer immunotherapy and/or modulators of intratumoral interferon |
| US11603532B2 (en) * | 2017-06-02 | 2023-03-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| CN115916978A (zh) | 2020-05-19 | 2023-04-04 | 哈德森医学研究所 | 寡核苷酸 |
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2021
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- 2021-05-19 EP EP21807588.5A patent/EP4153751A4/en active Pending
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- 2021-05-19 US US17/926,383 patent/US20230348903A1/en not_active Abandoned
- 2021-05-19 BR BR112022023310A patent/BR112022023310A2/pt unknown
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|---|---|
| US20240287510A1 (en) | 2024-08-29 |
| EP4153751A1 (en) | 2023-03-29 |
| CN115916978A (zh) | 2023-04-04 |
| EP4153751A4 (en) | 2025-12-17 |
| AU2021276730A1 (en) | 2023-01-05 |
| WO2021232099A1 (en) | 2021-11-25 |
| US12448622B2 (en) | 2025-10-21 |
| BR112022023310A2 (pt) | 2023-01-24 |
| CA3171986A1 (en) | 2021-11-25 |
| US20230348903A1 (en) | 2023-11-02 |
| MX2022014495A (es) | 2023-03-10 |
| JP2023526090A (ja) | 2023-06-20 |
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