KR20230010593A - MARC1 유전자를 표적으로 하는 RNAi 제제 및 이의 용도 - Google Patents
MARC1 유전자를 표적으로 하는 RNAi 제제 및 이의 용도 Download PDFInfo
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- KR20230010593A KR20230010593A KR1020220084498A KR20220084498A KR20230010593A KR 20230010593 A KR20230010593 A KR 20230010593A KR 1020220084498 A KR1020220084498 A KR 1020220084498A KR 20220084498 A KR20220084498 A KR 20220084498A KR 20230010593 A KR20230010593 A KR 20230010593A
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- rnai agent
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020210089864 | 2021-07-08 | ||
| KR20210089864 | 2021-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20230010593A true KR20230010593A (ko) | 2023-01-19 |
Family
ID=84801791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020220084498A Pending KR20230010593A (ko) | 2021-07-08 | 2022-07-08 | MARC1 유전자를 표적으로 하는 RNAi 제제 및 이의 용도 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250179498A1 (enExample) |
| EP (1) | EP4368717A1 (enExample) |
| JP (1) | JP7853399B2 (enExample) |
| KR (1) | KR20230010593A (enExample) |
| CN (1) | CN117677697A (enExample) |
| AU (1) | AU2022308807B2 (enExample) |
| CA (1) | CA3225054A1 (enExample) |
| WO (1) | WO2023282704A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024186171A1 (ko) * | 2023-03-08 | 2024-09-12 | 올릭스 주식회사 | 비만의 예방 또는 치료용 RNAi 제제 및 이를 이용한 병용 요법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR090905A1 (es) * | 2012-05-02 | 2014-12-17 | Merck Sharp & Dohme | Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica |
| EA038792B1 (ru) * | 2013-05-22 | 2021-10-20 | Элнилэм Фармасьютикалз, Инк. | КОМПОЗИЦИИ НА ОСНОВЕ RNAi Serpina1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| US10835581B2 (en) * | 2017-11-28 | 2020-11-17 | University of Pittsburgh—of the Commonwealth System of Higher Education | Method of treating insulin resistance |
| WO2020123410A1 (en) * | 2018-12-10 | 2020-06-18 | Amgen Inc. | CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF |
| WO2020154567A1 (en) * | 2019-01-25 | 2020-07-30 | Viscient Biosciences, Inc. | Compositions and methods for the diagnosis and treatment of diseases of the liver |
| US12215382B2 (en) * | 2019-03-01 | 2025-02-04 | The General Hospital Corporation | Liver protective MARC variants and uses thereof |
| US20230183707A1 (en) * | 2020-05-21 | 2023-06-15 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting marc1 gene expression |
| KR20230046319A (ko) * | 2020-08-13 | 2023-04-05 | 암젠 인크 | MARC1 발현을 억제하기 위한 RNAi 작제물 및 방법 |
| EP4347820A1 (en) * | 2021-05-28 | 2024-04-10 | Novo Nordisk A/S | Compositions and methods for inhibiting mitochondria amidoxime reducing component 1 (marc1) expression |
-
2022
- 2022-07-08 CA CA3225054A patent/CA3225054A1/en active Pending
- 2022-07-08 WO PCT/KR2022/009984 patent/WO2023282704A1/ko not_active Ceased
- 2022-07-08 CN CN202280048413.XA patent/CN117677697A/zh active Pending
- 2022-07-08 EP EP22838056.4A patent/EP4368717A1/en active Pending
- 2022-07-08 US US18/577,278 patent/US20250179498A1/en active Pending
- 2022-07-08 AU AU2022308807A patent/AU2022308807B2/en active Active
- 2022-07-08 JP JP2024500173A patent/JP7853399B2/ja active Active
- 2022-07-08 KR KR1020220084498A patent/KR20230010593A/ko active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024186171A1 (ko) * | 2023-03-08 | 2024-09-12 | 올릭스 주식회사 | 비만의 예방 또는 치료용 RNAi 제제 및 이를 이용한 병용 요법 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3225054A1 (en) | 2023-02-12 |
| EP4368717A1 (en) | 2024-05-15 |
| US20250179498A1 (en) | 2025-06-05 |
| CN117677697A (zh) | 2024-03-08 |
| JP7853399B2 (ja) | 2026-04-28 |
| AU2022308807B2 (en) | 2026-02-12 |
| WO2023282704A1 (ko) | 2023-01-12 |
| JP2024525078A (ja) | 2024-07-09 |
| AU2022308807A1 (en) | 2024-02-01 |
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