KR20220166879A - 펩티드 접합된 입자 - Google Patents

펩티드 접합된 입자 Download PDF

Info

Publication number
KR20220166879A
KR20220166879A KR1020227042654A KR20227042654A KR20220166879A KR 20220166879 A KR20220166879 A KR 20220166879A KR 1020227042654 A KR1020227042654 A KR 1020227042654A KR 20227042654 A KR20227042654 A KR 20227042654A KR 20220166879 A KR20220166879 A KR 20220166879A
Authority
KR
South Korea
Prior art keywords
particles
plg
mice
antigen
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020227042654A
Other languages
English (en)
Korean (ko)
Inventor
로니 디. 쉬아
스테펜 디. 밀러
조나탄 운 텍 얍
다니엘 알. 게츠
데릭 맥카티
Original Assignee
노쓰웨스턴유니버시티
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 노쓰웨스턴유니버시티 filed Critical 노쓰웨스턴유니버시티
Priority to KR1020257011901A priority Critical patent/KR20250052503A/ko
Publication of KR20220166879A publication Critical patent/KR20220166879A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A61K47/6937—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol the polymer being PLGA, PLA or polyglycolic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
KR1020227042654A 2012-06-21 2013-06-21 펩티드 접합된 입자 Ceased KR20220166879A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257011901A KR20250052503A (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261662687P 2012-06-21 2012-06-21
US61/662,687 2012-06-21
KR1020217023650A KR20210096312A (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자
PCT/US2013/047079 WO2013192532A2 (en) 2012-06-21 2013-06-21 Peptide conjugated particles

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020217023650A Division KR20210096312A (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257011901A Division KR20250052503A (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자

Publications (1)

Publication Number Publication Date
KR20220166879A true KR20220166879A (ko) 2022-12-19

Family

ID=49769721

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020227042654A Ceased KR20220166879A (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자
KR1020217023650A Ceased KR20210096312A (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자
KR1020207021560A Active KR102283760B1 (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자
KR1020257011901A Pending KR20250052503A (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자
KR1020157001460A Active KR102139267B1 (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020217023650A Ceased KR20210096312A (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자
KR1020207021560A Active KR102283760B1 (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자
KR1020257011901A Pending KR20250052503A (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자
KR1020157001460A Active KR102139267B1 (ko) 2012-06-21 2013-06-21 펩티드 접합된 입자

Country Status (19)

Country Link
US (5) US10201596B2 (enExample)
EP (2) EP3607973A1 (enExample)
JP (5) JP6557140B2 (enExample)
KR (5) KR20220166879A (enExample)
CN (2) CN104684578B (enExample)
AU (5) AU2013278056B2 (enExample)
BR (1) BR112014032207B1 (enExample)
CA (2) CA2876495C (enExample)
DK (1) DK2863942T3 (enExample)
ES (1) ES2738481T3 (enExample)
HR (1) HRP20191178T1 (enExample)
IL (3) IL236191B (enExample)
MX (1) MX363889B (enExample)
PL (1) PL2863942T3 (enExample)
PT (1) PT2863942T (enExample)
RU (1) RU2669346C2 (enExample)
TR (1) TR201909998T4 (enExample)
WO (1) WO2013192532A2 (enExample)
ZA (1) ZA201409305B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101819688B1 (ko) 2010-11-12 2018-01-17 코어 파마슈티칼스 디벨롭먼트 컴퍼니 변형된 면역-조절 입자
EP2841098A4 (en) 2012-04-23 2016-03-02 Allertein Therapeutics Llc NANOPARTICLES FOR THE TREATMENT OF ALLERGIES
KR20220166879A (ko) 2012-06-21 2022-12-19 노쓰웨스턴유니버시티 펩티드 접합된 입자
EP2928500B1 (en) 2012-12-04 2019-03-06 Phosphorex Inc. Microparticles and nanoparticles having negative surface charges
IL303425A (en) 2013-03-13 2023-08-01 Cour Pharmaceuticals Dev Company Secondary vaccine particles for the treatment of inflammation
EP3760223A1 (en) 2013-04-03 2021-01-06 N-Fold Llc Nanoparticle composition for desensitizing a subject to peanut allergens
MX372849B (es) 2013-08-13 2020-07-06 Univ Northwestern Partículas conjugadas con péptidos.
US11510996B2 (en) * 2015-12-23 2022-11-29 Cour Pharmaceuticals Development Company Inc. Covalent polymer-antigen conjugated particles
CA3009799A1 (en) * 2016-01-04 2017-07-13 Cour Pharmaceuticals Development Company Inc. Particles encapsulating fusion proteins containing linked epitopes
GB2550586A (en) 2016-05-23 2017-11-29 A-Fax Ltd Racking protection device
US20210115378A1 (en) * 2018-05-09 2021-04-22 Yale University Compositions and systems for ex vivo cell modulation and methods of use thereof
WO2019217780A1 (en) * 2018-05-11 2019-11-14 Phosphorex, Inc. Microparticles and nanoparticles having negative surface charges
WO2020028909A1 (en) * 2018-08-03 2020-02-06 Brown University Oral formulations with increased uptake
US20220031632A1 (en) * 2020-05-14 2022-02-03 Op-T Llc Nanoparticle compositions and uses thereof
US20230287334A1 (en) * 2020-07-14 2023-09-14 Corning Incorporated Rapidly dissolving cell culture media powder and methods of making the same
IL312097A (en) 2021-10-21 2024-06-01 Cour Pharmaceuticals Dev Company Inc Treatment of primary biliary cirrhosis (PBC) with tolerable nanoparticles
CA3263470A1 (en) 2022-07-29 2024-02-01 Repertoire Immune Medicines, Inc. T-LYMPHOCYTE EPITOPES ASSOCIATED WITH TYPE 1 DIABETES
WO2024243410A1 (en) 2023-05-23 2024-11-28 Cour Pharmaceuticals Development Company Inc. Preparation of tolerizing nanoparticles for the treatment of primary biliary cholangitis
TW202500576A (zh) 2023-05-25 2025-01-01 美商庫爾製藥發展公司股份有限公司 以免疫耐受性(tolerizing)奈米粒子治療1型糖尿病(t1d)
WO2025072849A1 (en) 2023-09-29 2025-04-03 Repertoire Immune Medicines, Inc. Mhc-presentable peptides associated with type 1 diabetes

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565696A (en) * 1983-08-03 1986-01-21 The Regents Of The University Of California Production of immunogens by antigen conjugation to liposomes
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
JP3712260B2 (ja) 1992-02-28 2005-11-02 オートイミューン インク 自己免疫疾患のバイスタンダー抑制
FR2695563B1 (fr) 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
US6004763A (en) 1992-09-11 1999-12-21 Institut Pasteur Antigen-carrying microparticles and their use in the induction of humoral or cellular responses
JPH06157592A (ja) 1992-11-24 1994-06-03 Hitachi Chem Co Ltd ペプチドもしくはその誘導体、それらとタンパク質との結合体、及びこれらを免疫源とする抗エンドセリン−１抗体の製造方法
AU674584B2 (en) 1993-06-02 1997-01-02 Tvw Telethon Institute For Child Health Research Cryptic peptides for use in inducing immunologic tolerance
US5804201A (en) 1996-03-11 1998-09-08 The Rockefeller University Immunomodulatory peptides of vespid antigen 5
DE69818052T2 (de) 1997-03-31 2004-07-08 The Regents Of The University Of Michigan, Ann Arbor Offenporige bioabbaubare matrize
US7427602B1 (en) 1998-05-13 2008-09-23 The Regents Of The University Of Michigan Sustained DNA delivery from structural matrices
JP3926626B2 (ja) 1999-08-18 2007-06-06 キム・ホヨン 免疫学的寛容−誘導物質
WO2001094944A2 (en) 2000-06-02 2001-12-13 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
EP1311549A2 (en) 2000-08-22 2003-05-21 Micromet AG Composition for the elimination of autoreactive b-cells
US7029697B2 (en) 2001-02-14 2006-04-18 Northwestern University Controlled surface-associated delivery of genes and oligonucleotides
US6890556B1 (en) 2001-02-14 2005-05-10 Northwestern University Controlled surface-associated delivery of genes and oligonucleotides
NZ532274A (en) * 2001-10-03 2006-02-24 Chiron Corp Adjuvanted meningococcus compositions
EP1458361A4 (en) 2001-11-20 2007-04-25 Advanced Inhalation Res Inc COMPOSITIONS FOR DISTRIBUTING PRODUCTS WITH LASTING EFFECT
DE60335350D1 (de) 2002-03-19 2011-01-27 Powderject Res Ltd Adjuvantien für dns impstoffe basierend auf imidazochinoline
CA2483917C (en) 2002-05-02 2013-07-30 President And Fellows Of Harvard College Formulations limiting spread of pulmonary infections
DE60334474D1 (de) 2002-07-12 2010-11-18 Univ Johns Hopkins Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren
US7465463B2 (en) 2002-09-04 2008-12-16 Polyheal, Ltd. Compositions comprising microspheres with anti-inflammatory properties for healing of ocular tissues
US20060189554A1 (en) * 2002-09-24 2006-08-24 Russell Mumper Nanoparticle-Based vaccine delivery system containing adjuvant
WO2005000272A1 (en) 2003-06-04 2005-01-06 Isis Pharmaceuticals, Inc. Long-circulating liposomal compositions
WO2005015160A2 (en) 2003-08-07 2005-02-17 The Children's Hospital Of Philadelphia Functionalized polymeric colloids
WO2005019429A2 (en) 2003-08-22 2005-03-03 Potentia Pharmaceuticals, Inc. Compositions and methods for enhancing phagocytosis or phagocyte activity
US9149440B2 (en) 2003-09-02 2015-10-06 University Of South Florida Nanoparticles for drug-delivery
CA2545276C (en) 2003-11-05 2016-05-31 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer
EP1547581A1 (en) * 2003-12-23 2005-06-29 Vectron Therapeutics AG Liposomal vaccine for the treatment of human hematological malignancies
ES2246695B1 (es) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
US7846466B2 (en) 2004-06-10 2010-12-07 Northwestern University Biodegradable scaffolds and uses thereof
EP1768692B8 (en) 2004-07-01 2015-06-17 Yale University Targeted and high density drug loaded polymeric materials
JP2006248978A (ja) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
US20110182805A1 (en) 2005-06-17 2011-07-28 Desimone Joseph M Nanoparticle fabrication methods, systems, and materials
WO2007003327A1 (en) 2005-07-01 2007-01-11 Roche Diagnostics Gmbh Carboxylated latex particles
WO2007008755A2 (en) 2005-07-08 2007-01-18 The Board Of Regents, The University Of Texas System Surface functionalization of polymeric materials
GB0514262D0 (en) 2005-07-12 2005-08-17 Renovo Ltd Promotion of epithelial regeneration
US20070041934A1 (en) 2005-08-12 2007-02-22 Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
WO2007087341A2 (en) 2006-01-25 2007-08-02 The Board Of Trustees Of The University Of Illinois Tolerogenic biodegradable artificial antigen presenting system
US20090304726A1 (en) 2006-02-15 2009-12-10 Ramot At Tel Aviv University Ltd. Viral display vehicles for treating multiple sclerosis
JP2009527572A (ja) * 2006-02-24 2009-07-30 ノバルティス アーゲー 免疫原性組成物に使用するための生分解性ポリマーおよびカチオン性多糖を含むミクロ粒子
EP2061446A2 (en) 2006-07-28 2009-05-27 University Court of the University of Edinburgh Use of cdk inhibitors for the treatment of granulocyte mediated disorders
EP2077821B1 (en) 2006-10-12 2019-08-14 The University Of Queensland Compositions and methods for modulating immune responses
US20090214474A1 (en) 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
AU2007336297B2 (en) 2006-12-18 2013-09-05 Colorobbia Italia S.P.A. Magnetic nanoparticles for the application in hyperthermia, preparation thereof and use in constructs having a pharmacological application
EP3269384A1 (en) 2007-03-07 2018-01-17 Uti Limited Partnership Compositions and methods for the prevention and treatment of autoimmune conditions
US20080311140A1 (en) 2007-05-29 2008-12-18 Baylor College Of Medicine Antigen specific immunosuppression by dendritic cell therapy
CN101918028B (zh) * 2007-09-18 2015-01-07 莱戈赛特医药股份有限公司 赋予针对诺如病毒的保护性免疫应答的疫苗
EP2620157A3 (en) * 2007-10-12 2013-10-16 Massachusetts Institute of Technology Vaccine nanotechnology
WO2009049365A1 (en) 2007-10-15 2009-04-23 Cooperative Research Centre For Asthma A method of prophylaxis and agents for use therein
WO2009052561A1 (en) 2007-10-22 2009-04-30 The Walter And Eliza Hall Institute Of Medical Research Compositions and methods for manipulating an immune response
EP2057998A1 (en) 2007-10-31 2009-05-13 Universitätsklinikum Hamburg-Eppendorf Use of modified cells for the treatment of multiple sclerosis
US20090123509A1 (en) 2007-11-08 2009-05-14 Cory Berkland Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds
US20090238879A1 (en) 2008-01-24 2009-09-24 Northwestern University Delivery scaffolds and related methods of use
WO2009131712A2 (en) 2008-04-25 2009-10-29 Duke University Medical Center Regulatory b cells and their uses
US20110206773A1 (en) 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
EP2123261A1 (en) 2008-05-20 2009-11-25 Stallergenes S.A. Mucoadhesive particulate formulation for inducing antigen-specific immune tolerance
US8323696B2 (en) 2008-08-29 2012-12-04 Ecole Polytechnique Federale De Lausanne Nanoparticles for immunotherapy
US9149441B2 (en) 2008-09-29 2015-10-06 The Corporation Of Mercer University Nanospheres encapsulating bioactive material and method for formulation of nanospheres
AU2009298112B2 (en) 2008-10-02 2015-11-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Administration of an adsorbent polymer for treatment of systemic inflammation
MX346450B (es) 2008-11-30 2017-03-17 Immusant Inc * Composiciones y métodos para el tratamiento de la enfermedad celíaca.
EP2376115A4 (en) 2008-12-11 2013-07-03 Univ Alberta METHOD AND SYSTEM FOR INDUCING IMMUNOLOGICAL TOLERANCE IN RESELLERS
JP2012515722A (ja) 2009-01-20 2012-07-12 ノースウェスタン ユニバーシティ 抗原特異的寛容の誘導のための組成物および方法
EP2255831A1 (en) 2009-05-25 2010-12-01 Institut Pasteur Liposome based diepitope constructs
JP6282395B2 (ja) 2009-05-27 2018-02-21 セレクタ バイオサイエンシーズ インコーポレーテッドＳｅｌｅｃｔａ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 異なる放出速度の構成要素を有するナノキャリア
WO2011031441A1 (en) 2009-08-28 2011-03-17 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Therapy with a chimeric molecule and a pro-apoptotic agent
US20110135744A1 (en) 2009-12-03 2011-06-09 The Regents Of The University Of California Nanoparticle Based Therapy for Dispersing Mucin
US20130209564A1 (en) 2010-02-22 2013-08-15 Shyam M. Rele Polysaccharide Particle Vaccines
US8207290B2 (en) 2010-03-26 2012-06-26 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
WO2011133617A1 (en) * 2010-04-23 2011-10-27 The Board Of Trustees Of The University Of Illinois Nano-hybrid delivery system for sequential utilization of passive and active targeting
US9408906B2 (en) 2010-06-04 2016-08-09 Flow Pharma, Inc. Peptide particle formulation
WO2011150573A1 (en) * 2010-06-04 2011-12-08 Tongji University Copolymer of pyrene and pyrrole and method of producing the copolymer
US20130209463A1 (en) 2010-06-30 2013-08-15 Compugen Ltd. Polypeptides and uses thereof as a drug for treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders
WO2012018380A2 (en) 2010-07-31 2012-02-09 The Scripps Research Institute Compositions and methods for inducing immune tolerance
US10131875B2 (en) 2010-08-04 2018-11-20 Duke University Regulatory B cells and their uses
KR101819688B1 (ko) 2010-11-12 2018-01-17 코어 파마슈티칼스 디벨롭먼트 컴퍼니 변형된 면역-조절 입자
SG190798A1 (en) * 2010-11-24 2013-07-31 Univ Nanyang Tech Method for coating particles with calcium phosphate and particles, microparticles and nanoparticles formed thereof
US10064406B2 (en) 2011-01-06 2018-09-04 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
US20130266625A1 (en) 2011-01-24 2013-10-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Nanoparticles based on poly (lactic glycolic) acid for cosmetic applications
CN103501812A (zh) 2011-04-29 2014-01-08 西莱克塔生物科技公司 用于过敏症治疗的致耐受性合成纳米载体
US20130039954A1 (en) 2011-07-29 2013-02-14 Selecta Biosciences, Inc. Control of antibody responses to synthetic nanocarriers
US20130058902A1 (en) 2011-09-06 2013-03-07 Selecta Biosciences, Inc. Dendritic cell subsets for generating induced tolerogenic dendritic cells and related compositions and methods
HK1204970A1 (en) 2012-01-31 2015-12-11 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
KR20220166879A (ko) 2012-06-21 2022-12-19 노쓰웨스턴유니버시티 펩티드 접합된 입자
IL303425A (en) 2013-03-13 2023-08-01 Cour Pharmaceuticals Dev Company Secondary vaccine particles for the treatment of inflammation
MX372849B (es) 2013-08-13 2020-07-06 Univ Northwestern Partículas conjugadas con péptidos.

Also Published As

Publication number Publication date
CA2876495C (en) 2023-10-17
MX2014015843A (es) 2016-05-05
KR20210096312A (ko) 2021-08-04
WO2013192532A3 (en) 2015-04-02
DK2863942T3 (da) 2019-07-15
ES2738481T3 (es) 2020-01-23
KR20150032869A (ko) 2015-03-30
BR112014032207A2 (pt) 2017-08-01
JP2025163048A (ja) 2025-10-28
AU2018236881A1 (en) 2018-10-25
AU2020244453B2 (en) 2025-02-20
KR20200091506A (ko) 2020-07-30
CN110064049B (zh) 2024-02-09
PL2863942T3 (pl) 2019-12-31
US20250009858A1 (en) 2025-01-09
ZA201409305B (en) 2019-08-28
HRP20191178T1 (hr) 2019-10-04
KR102283760B1 (ko) 2021-08-03
CA2876495A1 (en) 2013-12-27
CN110064049A (zh) 2019-07-30
JP7210306B2 (ja) 2023-01-23
CA3211102A1 (en) 2013-12-27
EP2863942B1 (en) 2019-04-10
IL236191B (en) 2019-05-30
JP2021165273A (ja) 2021-10-14
MX363889B (es) 2019-04-05
AU2013278056A1 (en) 2015-01-22
IL236191A0 (en) 2015-01-29
IL290884A (en) 2022-04-01
EP2863942A2 (en) 2015-04-29
JP6557140B2 (ja) 2019-08-07
JP2015522569A (ja) 2015-08-06
EP3607973A1 (en) 2020-02-12
BR112014032207B1 (pt) 2021-07-27
AU2020203884A1 (en) 2020-07-02
AU2013278056B2 (en) 2018-07-05
PT2863942T (pt) 2019-07-17
US20150209293A1 (en) 2015-07-30
EP2863942A4 (en) 2016-04-27
US20190262441A1 (en) 2019-08-29
CN104684578B (zh) 2019-04-19
US20200330569A1 (en) 2020-10-22
RU2669346C2 (ru) 2018-10-10
JP2023153869A (ja) 2023-10-18
US10201596B2 (en) 2019-02-12
US20240082371A1 (en) 2024-03-14
JP2019142844A (ja) 2019-08-29
CN104684578A (zh) 2015-06-03
RU2015101758A (ru) 2016-08-20
IL290884B1 (en) 2025-12-01
US11413337B2 (en) 2022-08-16
AU2020244453A1 (en) 2020-10-29
JP7491869B2 (ja) 2024-05-28
HK1209039A1 (en) 2016-03-24
KR20250052503A (ko) 2025-04-18
WO2013192532A2 (en) 2013-12-27
US11826407B2 (en) 2023-11-28
AU2025203403A1 (en) 2025-05-29
KR102139267B1 (ko) 2020-07-31
IL266880B (en) 2022-04-01
TR201909998T4 (tr) 2019-07-22
IL266880A (en) 2019-07-31
AU2018236881B2 (en) 2020-07-02

Similar Documents

Publication Publication Date Title
JP7408604B2 (ja) ペプチドコンジュゲート粒子
US20250009858A1 (en) Peptide Conjugated Particles
HK40023216A (en) Peptide conjugated particles
RU2813163C2 (ru) Частицы, конъюгированные с пептидом
HK1209039B (en) Peptide conjugated particles

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20221205

Application number text: 1020217023650

Filing date: 20210726

PG1501 Laying open of application
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20230111

Patent event code: PE09021S01D

PE0601 Decision on rejection of patent

Patent event date: 20240624

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

AMND Amendment
PX0901 Re-examination

Patent event code: PX09012R01I

Patent event date: 20241021

Comment text: Amendment to Specification, etc.

PX0601 Decision of rejection after re-examination

Comment text: Decision to Refuse Application

Patent event code: PX06014S01D

Patent event date: 20241114

Comment text: Decision to Refuse Application

Patent event code: PX06011S01I

Patent event date: 20241114

X601 Decision of rejection after re-examination