KR20220127859A - Ccr5 양성 전이성 암 치료를 위한 ccr5 결합제 - Google Patents

Ccr5 양성 전이성 암 치료를 위한 ccr5 결합제 Download PDF

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KR20220127859A
KR20220127859A KR1020227027622A KR20227027622A KR20220127859A KR 20220127859 A KR20220127859 A KR 20220127859A KR 1020227027622 A KR1020227027622 A KR 1020227027622A KR 20227027622 A KR20227027622 A KR 20227027622A KR 20220127859 A KR20220127859 A KR 20220127859A
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cancer
ccr5
antibody
seq
ser
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스코트 켈리
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사이토딘 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020227027622A 2020-01-13 2021-01-13 Ccr5 양성 전이성 암 치료를 위한 ccr5 결합제 Pending KR20220127859A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202062960613P 2020-01-13 2020-01-13
US62/960,613 2020-01-13
US202062968954P 2020-01-31 2020-01-31
US62/968,954 2020-01-31
US202062977023P 2020-02-14 2020-02-14
US62/977,023 2020-02-14
PCT/US2021/013289 WO2021146323A1 (en) 2020-01-13 2021-01-13 Ccr5 binding agent for treatment of ccr5 positive metastatic breast cancer

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Publication Number Publication Date
KR20220127859A true KR20220127859A (ko) 2022-09-20

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Application Number Title Priority Date Filing Date
KR1020227027622A Pending KR20220127859A (ko) 2020-01-13 2021-01-13 Ccr5 양성 전이성 암 치료를 위한 ccr5 결합제

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Country Link
US (1) US20210214448A1 (https=)
EP (1) EP4090675A4 (https=)
JP (1) JP2023511277A (https=)
KR (1) KR20220127859A (https=)
CN (1) CN115003691A (https=)
AU (1) AU2021207851A1 (https=)
BR (1) BR112022012821A2 (https=)
CA (1) CA3163060A1 (https=)
IL (1) IL294113A (https=)
MX (1) MX2022008632A (https=)
WO (1) WO2021146323A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021019405A2 (pt) * 2019-04-01 2021-11-30 Cytodyn Inc Agentes anti-ccr5 e métodos de tratamento que bloqueiam a metástase do câncer ou aumentam a morte celular induzida pela quimioterapia prejudicial ao dna

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US7122185B2 (en) * 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
NZ534947A (en) * 2002-02-22 2008-03-28 Progenics Pharm Inc Anti-CCR5 antibody that binds to CCR5 on the surface of a human cell.
WO2007113648A2 (en) * 2006-04-05 2007-10-11 Pfizer Products Inc. Ctla4 antibody combination therapy
JP6518585B2 (ja) * 2012-05-14 2019-05-22 リチャード ジー． ペステル がんの治療のためのｃｃｒ５の修飾薬の使用
CN106413751A (zh) * 2014-05-21 2017-02-15 辉瑞大药厂 用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合
WO2016073380A1 (en) * 2014-11-03 2016-05-12 Genentech, Inc. Method and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment
CN107847514A (zh) * 2015-06-23 2018-03-27 西托戴恩股份有限公司 炎症、癌症、自身免疫和其它病症中ccl5配体结合ccr5受体的抑制作用和ccr5/ccl5轴信号传导的改变
KR20190003958A (ko) * 2016-04-15 2019-01-10 제넨테크, 인크. 암의 치료 및 모니터링 방법
WO2018085513A1 (en) * 2016-11-04 2018-05-11 Genentech, Inc. Treatment of her2-positive breast cancer
CN111886249A (zh) * 2017-09-18 2020-11-03 西托戴恩股份有限公司 用于鉴定和治疗适合长期抗-ccr5剂治疗的hiv-1感染患者亚群的筛选方法
EP3773676A4 (en) * 2018-04-03 2022-05-18 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and an antigen associated with tumors, mdscs and/or tams
CN112639137A (zh) * 2018-07-02 2021-04-09 茵赛德斯有限公司 用于检测癌症相关细胞群体、进行转移性癌症筛查及治疗的方法
BR112021019405A2 (pt) * 2019-04-01 2021-11-30 Cytodyn Inc Agentes anti-ccr5 e métodos de tratamento que bloqueiam a metástase do câncer ou aumentam a morte celular induzida pela quimioterapia prejudicial ao dna

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CN115003691A (zh) 2022-09-02
WO2021146323A9 (en) 2021-08-26
CA3163060A1 (en) 2021-07-22
AU2021207851A1 (en) 2022-07-14
EP4090675A4 (en) 2024-02-21
BR112022012821A2 (pt) 2022-12-13
JP2023511277A (ja) 2023-03-17
EP4090675A1 (en) 2022-11-23
IL294113A (en) 2022-08-01
WO2021146323A1 (en) 2021-07-22
US20210214448A1 (en) 2021-07-15
MX2022008632A (es) 2022-08-08

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