CN115003691A - 用于治疗ccr5阳性转移癌的ccr5结合剂 - Google Patents

用于治疗ccr5阳性转移癌的ccr5结合剂 Download PDF

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Publication number
CN115003691A
CN115003691A CN202180008905.1A CN202180008905A CN115003691A CN 115003691 A CN115003691 A CN 115003691A CN 202180008905 A CN202180008905 A CN 202180008905A CN 115003691 A CN115003691 A CN 115003691A
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cancer
ccr5
antibody
seq
ser
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Chinese (zh)
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S·凯利
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Cytodyn Inc
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Cytodyn Inc
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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CN202180008905.1A 2020-01-13 2021-01-13 用于治疗ccr5阳性转移癌的ccr5结合剂 Pending CN115003691A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202062960613P 2020-01-13 2020-01-13
US62/960,613 2020-01-13
US202062968954P 2020-01-31 2020-01-31
US62/968,954 2020-01-31
US202062977023P 2020-02-14 2020-02-14
US62/977,023 2020-02-14
PCT/US2021/013289 WO2021146323A1 (en) 2020-01-13 2021-01-13 Ccr5 binding agent for treatment of ccr5 positive metastatic breast cancer

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CN115003691A true CN115003691A (zh) 2022-09-02

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CN202180008905.1A Pending CN115003691A (zh) 2020-01-13 2021-01-13 用于治疗ccr5阳性转移癌的ccr5结合剂

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US (1) US20210214448A1 (https=)
EP (1) EP4090675A4 (https=)
JP (1) JP2023511277A (https=)
KR (1) KR20220127859A (https=)
CN (1) CN115003691A (https=)
AU (1) AU2021207851A1 (https=)
BR (1) BR112022012821A2 (https=)
CA (1) CA3163060A1 (https=)
IL (1) IL294113A (https=)
MX (1) MX2022008632A (https=)
WO (1) WO2021146323A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021019405A2 (pt) * 2019-04-01 2021-11-30 Cytodyn Inc Agentes anti-ccr5 e métodos de tratamento que bloqueiam a metástase do câncer ou aumentam a morte celular induzida pela quimioterapia prejudicial ao dna

Citations (7)

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CN106413751A (zh) * 2014-05-21 2017-02-15 辉瑞大药厂 用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合
CN107109484A (zh) * 2014-11-03 2017-08-29 豪夫迈·罗氏有限公司 用于ox40激动剂治疗的功效预测和评估的方法和生物标志物
CN107847514A (zh) * 2015-06-23 2018-03-27 西托戴恩股份有限公司 炎症、癌症、自身免疫和其它病症中ccl5配体结合ccr5受体的抑制作用和ccr5/ccl5轴信号传导的改变
CN109154613A (zh) * 2016-04-15 2019-01-04 豪夫迈·罗氏有限公司 用于监测和治疗癌症的方法
WO2019195409A1 (en) * 2018-04-03 2019-10-10 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and an antigen associated with tumors, mdscs and/or tams
CN110505880A (zh) * 2016-11-04 2019-11-26 基因泰克公司 Her2阳性乳腺癌的治疗
WO2020009988A1 (en) * 2018-07-02 2020-01-09 Incelldx, Inc. Methods for detecting cancer-related cell populations, screening for metastatic cancer and treatments thereof

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US7122185B2 (en) * 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
NZ534947A (en) * 2002-02-22 2008-03-28 Progenics Pharm Inc Anti-CCR5 antibody that binds to CCR5 on the surface of a human cell.
WO2007113648A2 (en) * 2006-04-05 2007-10-11 Pfizer Products Inc. Ctla4 antibody combination therapy
JP6518585B2 (ja) * 2012-05-14 2019-05-22 リチャード ジー． ペステル がんの治療のためのｃｃｒ５の修飾薬の使用
CN111886249A (zh) * 2017-09-18 2020-11-03 西托戴恩股份有限公司 用于鉴定和治疗适合长期抗-ccr5剂治疗的hiv-1感染患者亚群的筛选方法
BR112021019405A2 (pt) * 2019-04-01 2021-11-30 Cytodyn Inc Agentes anti-ccr5 e métodos de tratamento que bloqueiam a metástase do câncer ou aumentam a morte celular induzida pela quimioterapia prejudicial ao dna

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106413751A (zh) * 2014-05-21 2017-02-15 辉瑞大药厂 用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合
CN107109484A (zh) * 2014-11-03 2017-08-29 豪夫迈·罗氏有限公司 用于ox40激动剂治疗的功效预测和评估的方法和生物标志物
CN107847514A (zh) * 2015-06-23 2018-03-27 西托戴恩股份有限公司 炎症、癌症、自身免疫和其它病症中ccl5配体结合ccr5受体的抑制作用和ccr5/ccl5轴信号传导的改变
CN109154613A (zh) * 2016-04-15 2019-01-04 豪夫迈·罗氏有限公司 用于监测和治疗癌症的方法
CN110505880A (zh) * 2016-11-04 2019-11-26 基因泰克公司 Her2阳性乳腺癌的治疗
WO2019195409A1 (en) * 2018-04-03 2019-10-10 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and an antigen associated with tumors, mdscs and/or tams
WO2020009988A1 (en) * 2018-07-02 2020-01-09 Incelldx, Inc. Methods for detecting cancer-related cell populations, screening for metastatic cancer and treatments thereof

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KR20220127859A (ko) 2022-09-20
WO2021146323A9 (en) 2021-08-26
CA3163060A1 (en) 2021-07-22
AU2021207851A1 (en) 2022-07-14
EP4090675A4 (en) 2024-02-21
BR112022012821A2 (pt) 2022-12-13
JP2023511277A (ja) 2023-03-17
EP4090675A1 (en) 2022-11-23
IL294113A (en) 2022-08-01
WO2021146323A1 (en) 2021-07-22
US20210214448A1 (en) 2021-07-15
MX2022008632A (es) 2022-08-08

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