KR20220122615A - Ｔ 세포 요법 및 (ｓ)-3-[4-(4-모르폴린-4-일메틸-벤질옥시)-1-옥소-1,3-디하이드로-이소인돌-2-일]-피페리딘-2,6-디온의 병용 - Google Patents

Ｔ 세포 요법 및 (ｓ)-3-[4-(4-모르폴린-4-일메틸-벤질옥시)-1-옥소-1,3-디하이드로-이소인돌-2-일]-피페리딘-2,6-디온의 병용 Download PDF

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KR20220122615A
KR20220122615A KR1020227018962A KR20227018962A KR20220122615A KR 20220122615 A KR20220122615 A KR 20220122615A KR 1020227018962 A KR1020227018962 A KR 1020227018962A KR 20227018962 A KR20227018962 A KR 20227018962A KR 20220122615 A KR20220122615 A KR 20220122615A
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administration
cells
compound
subject
cell
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마이클 포츠
젠스 하스칼
샌드린 몬트허드
마이클 푸어덴나드
팀 풀햄
짐 킨
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주노 쎄러퓨티크스 인코퍼레이티드
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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KR1020227018962A 2019-11-07 2020-11-06 Ｔ 세포 요법 및 (ｓ)-3-[4-(4-모르폴린-4-일메틸-벤질옥시)-1-옥소-1,3-디하이드로-이소인돌-2-일]-피페리딘-2,6-디온의 병용 Pending KR20220122615A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962932500P 2019-11-07 2019-11-07
US62/932,500 2019-11-07
US202063016977P 2020-04-28 2020-04-28
US63/016,977 2020-04-28
PCT/US2020/059550 WO2021092498A1 (en) 2019-11-07 2020-11-06 Combination of a t cell therapy and (s)-3-[4-(4-morpholin-4 ylmethyl-benzyloxy)-l-oxo-l,3-dihydro-isoindol-2-yl]- piperidine-2,6-dione

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KR20220122615A true KR20220122615A (ko) 2022-09-02

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KR1020227018962A Pending KR20220122615A (ko) 2019-11-07 2020-11-06 Ｔ 세포 요법 및 (ｓ)-3-[4-(4-모르폴린-4-일메틸-벤질옥시)-1-옥소-1,3-디하이드로-이소인돌-2-일]-피페리딘-2,6-디온의 병용

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US (1) US20220401483A1 (https=)
EP (1) EP4054623A1 (https=)
JP (1) JP7837864B2 (https=)
KR (1) KR20220122615A (https=)
CN (1) CN114980918A (https=)
AU (1) AU2020379043A1 (https=)
BR (1) BR112022007548A2 (https=)
IL (1) IL292667B1 (https=)
MX (1) MX2022005524A (https=)
WO (1) WO2021092498A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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EP4054623A1 (en) 2022-09-14
CN114980918A (zh) 2022-08-30
AU2020379043A8 (en) 2022-07-14
MX2022005524A (es) 2022-08-25
IL292667B1 (en) 2026-02-01
US20220401483A1 (en) 2022-12-22
JP7837864B2 (ja) 2026-03-31
AU2020379043A1 (en) 2022-06-02
JP2022554353A (ja) 2022-12-28
WO2021092498A1 (en) 2021-05-14
IL292667A (en) 2022-07-01

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St.27 status event code: A-1-2-D10-D21-exm-PE0902