KR20220119063A - 치료용 조작 세포 - Google Patents

치료용 조작 세포 Download PDF

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Publication number
KR20220119063A
KR20220119063A KR1020227023757A KR20227023757A KR20220119063A KR 20220119063 A KR20220119063 A KR 20220119063A KR 1020227023757 A KR1020227023757 A KR 1020227023757A KR 20227023757 A KR20227023757 A KR 20227023757A KR 20220119063 A KR20220119063 A KR 20220119063A
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South Korea
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cell
receptor
cells
differentiated
rna
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KR1020227023757A
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English (en)
Korean (ko)
Inventor
지. 그랜트 웰스테드
중 일 문
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에디타스 메디신, 인코포레이티드
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Publication of KR20220119063A publication Critical patent/KR20220119063A/ko
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61K2121/00—Preparations for use in therapy
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Virology (AREA)
KR1020227023757A 2019-12-18 2020-12-18 치료용 조작 세포 Pending KR20220119063A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962950063P 2019-12-18 2019-12-18
US62/950,063 2019-12-18
US202063025735P 2020-05-15 2020-05-15
US63/025,735 2020-05-15
US202063115592P 2020-11-18 2020-11-18
US63/115,592 2020-11-18
PCT/US2020/066256 WO2021127594A1 (en) 2019-12-18 2020-12-18 Engineered cells for therapy

Publications (1)

Publication Number Publication Date
KR20220119063A true KR20220119063A (ko) 2022-08-26

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ID=76478017

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Application Number Title Priority Date Filing Date
KR1020227023757A Pending KR20220119063A (ko) 2019-12-18 2020-12-18 치료용 조작 세포

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US (1) US20230053028A1 (https=)
EP (1) EP4076479A4 (https=)
JP (1) JP2023507118A (https=)
KR (1) KR20220119063A (https=)
CN (1) CN114929250A (https=)
AU (1) AU2020405203A1 (https=)
CA (1) CA3164660A1 (https=)
IL (1) IL293946A (https=)
WO (1) WO2021127594A1 (https=)

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CN120174005A (zh) 2019-02-13 2025-06-20 比姆医疗股份有限公司 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
EP4034138A4 (en) 2019-09-27 2024-07-31 Beam Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
CA3196831A1 (en) 2020-09-25 2022-03-31 Beam Therapeutics Inc. Fratricide resistant modified immune cells and methods of using the same
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
KR20230118887A (ko) 2020-12-03 2023-08-14 센츄리 쎄라퓨틱스 인코포레이티드 유전자 조작 세포 및 이의 용도
AR124414A1 (es) 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
WO2023108107A2 (en) * 2021-12-10 2023-06-15 Beam Therapeutics Inc. Modified immune cells and methods of using the same
CN117384853B (zh) * 2022-07-11 2025-12-19 士泽生物医药（苏州）有限公司 一种表达pvr的通用型细胞及其制备方法
AU2023356353A1 (en) * 2022-10-05 2025-05-08 Garuda Therapeutics, Inc. Modified hematopoietic stem cells and progenies thereof
WO2025166325A1 (en) * 2024-02-02 2025-08-07 Editas Medicine, Inc. MODIFIED GUIDE RNAs
WO2025238593A1 (en) * 2024-05-16 2025-11-20 Fondazione Istituto Italiano Di Tecnologia DESIGN OF SYNTHETIC miRNAS TO RESTORE THE CORRECT GENE DOSAGE OF GENES ASSOCIATED WITH T LYMPHOCYTE EXHAUSTION

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US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
US20030073623A1 (en) * 2001-07-30 2003-04-17 Drmanac Radoje T. Novel nucleic acid sequences obtained from various cDNA libraries
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US9233926B2 (en) * 2008-09-17 2016-01-12 Sanford-Burnham Medical Research Institute Compounds for stem cell differentiation
EP3495497B1 (en) * 2011-04-28 2021-03-24 Life Technologies Corporation Methods and compositions for multiplex pcr
KR20260004568A (ko) * 2016-04-19 2026-01-08 더 브로드 인스티튜트, 인코퍼레이티드 신규한 crispr 효소 및 시스템
AU2017347854B2 (en) * 2016-10-27 2022-12-08 Intima Bioscience, Inc. Viral methods of T cell therapy
EP3612210A4 (en) * 2017-04-19 2021-01-27 Board Of Regents, The University Of Texas System MANIPULATED ANTIGEN RECEPTORS EXPRESSING IMMUNE CELLS
BR112020006601A2 (pt) * 2017-10-02 2020-12-08 Genedit Inc. Rna guia de cpf1 modificado
WO2019089884A2 (en) * 2017-11-01 2019-05-09 Editas Medicine, Inc. Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy
KR102907245B1 (ko) * 2018-03-14 2026-01-05 에디타스 메디신, 인코포레이티드 혈색소병증 치료를 위한 시스템 및 방법
EP3790562A4 (en) * 2018-05-11 2022-01-12 The Regents of the University of California MODIFICATION OF IMMUNE CELLS TO INCREASE ACTIVITY
MX2021006208A (es) * 2018-11-28 2021-10-01 Univ Texas Edición por multiplexación del genoma de células inmunitarias para mejorar la funcionalidad y resistencia al entorno supresor.

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CN114929250A (zh) 2022-08-19
IL293946A (en) 2022-08-01
EP4076479A1 (en) 2022-10-26
CA3164660A1 (en) 2021-06-24
WO2021127594A1 (en) 2021-06-24
EP4076479A4 (en) 2024-05-22
AU2020405203A1 (en) 2022-07-14
JP2023507118A (ja) 2023-02-21
US20230053028A1 (en) 2023-02-16

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