KR20220116520A - 파타틴-유사 포스포리파제 도메인 함유 3 (PNPLA3) iRNA 조성물 및 이의 사용 방법 - Google Patents

파타틴-유사 포스포리파제 도메인 함유 3 (PNPLA3) iRNA 조성물 및 이의 사용 방법 Download PDF

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KR20220116520A
KR20220116520A KR1020227024693A KR20227024693A KR20220116520A KR 20220116520 A KR20220116520 A KR 20220116520A KR 1020227024693 A KR1020227024693 A KR 1020227024693A KR 20227024693 A KR20227024693 A KR 20227024693A KR 20220116520 A KR20220116520 A KR 20220116520A
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nucleotides
ome
strand
antisense strand
nucleotide
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프레데릭 트렘블레이
제임스 디. 맥시닌치
아담 카스토레노
마크 케이. 슐레겔
차랄람보스 카이타니스
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알닐람 파마슈티칼스 인코포레이티드
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Priority claimed from PCT/US2020/064776 external-priority patent/WO2021126734A1/en
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KR1020227024693A 2019-12-16 2020-12-14 파타틴-유사 포스포리파제 도메인 함유 3 (PNPLA3) iRNA 조성물 및 이의 사용 방법 Pending KR20220116520A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962948445P 2019-12-16 2019-12-16
US62/948,445 2019-12-16
US202063040602P 2020-06-18 2020-06-18
US63/040,602 2020-06-18
PCT/US2020/064776 WO2021126734A1 (en) 2019-12-16 2020-12-14 Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof

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KR20220116520A true KR20220116520A (ko) 2022-08-23

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US (2) US11149276B2 (https=)
EP (1) EP4077666A1 (https=)
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KR (1) KR20220116520A (https=)
CN (1) CN115176007A (https=)
AU (1) AU2020404905A1 (https=)
BR (1) BR112022011412A2 (https=)
CA (1) CA3164628A1 (https=)
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Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
CA2976445A1 (en) 2015-02-13 2016-08-18 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
EP4077666A1 (en) 2019-12-16 2022-10-26 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
AR121672A1 (es) * 2020-03-26 2022-06-29 Arrowhead Pharmaceuticals Inc AGENTES DE ARNi PARA INHIBIR LA EXPRESIÓN DE PNPLA3, COMPOSICIONES FARMACÉUTICAS DE ESTA, Y MÉTODOS DE USO
WO2024120412A1 (en) * 2022-12-07 2024-06-13 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of patatin-like phospholipase domain-containing 3 (pnpla3)
WO2025098440A1 (zh) * 2023-11-08 2025-05-15 浙江扬厉医药技术有限公司 抑制PNPLA3表达的双链siRNA以及其缀合物
WO2025242147A1 (zh) * 2024-05-21 2025-11-27 北京安龙生物医药有限公司 靶向外周髓鞘蛋白-22基因的寡核苷酸及其用途
WO2025252063A1 (zh) * 2024-06-04 2025-12-11 正大天晴药业集团股份有限公司 靶向pnpla3的双链核糖核酸

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AU2003295600A1 (en) 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
US7217807B2 (en) 2002-11-26 2007-05-15 Rosetta Genomics Ltd Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
WO2012177639A2 (en) 2011-06-22 2012-12-27 Alnylam Pharmaceuticals, Inc. Bioprocessing and bioproduction using avian cell lines
EP3730618A1 (en) 2011-11-18 2020-10-28 Alnylam Pharmaceuticals, Inc. Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases
SI3366775T2 (sl) 2011-11-18 2025-12-31 Alnylam Pharmaceuticals, Inc. Modificirana sredstva RNAI
EP2991136A1 (en) 2014-08-29 2016-03-02 Centre National De La Recherche Scientifique Method for manufacturing a miniaturized electrochemical cell
CA2976445A1 (en) * 2015-02-13 2016-08-18 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
WO2017048620A1 (en) 2015-09-14 2017-03-23 Alnylam Pharmaceuticals, Inc. Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
US10036024B2 (en) 2016-06-03 2018-07-31 Purdue Research Foundation siRNA compositions that specifically downregulate expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD)
UY38003A (es) 2017-12-12 2019-06-28 Amgen Inc Construcciones de arni para inhibir la expresión de pnpla3 y métodos de uso de las mismas
CN110384796A (zh) * 2019-07-11 2019-10-29 南京医科大学 马铃薯样磷脂酶7的应用
WO2021126734A1 (en) 2019-12-16 2021-06-24 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
EP4077666A1 (en) 2019-12-16 2022-10-26 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
EP4347823A1 (en) 2021-06-02 2024-04-10 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof

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JP7797388B2 (ja) 2026-01-13
US20210189400A1 (en) 2021-06-24
IL293860A (en) 2022-08-01
CA3164628A1 (en) 2021-06-24
AU2020404905A1 (en) 2022-06-23
EP4077666A1 (en) 2022-10-26
CO2022008105A2 (es) 2022-07-08
JP2023506258A (ja) 2023-02-15
BR112022011412A2 (pt) 2022-08-30
US12480125B2 (en) 2025-11-25
US20220348926A1 (en) 2022-11-03
US11149276B2 (en) 2021-10-19
PH12022551417A1 (en) 2023-11-20
CN115176007A (zh) 2022-10-11

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