KR20220113543A - 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법 - Google Patents

미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법 Download PDF

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KR20220113543A
KR20220113543A KR1020227026051A KR20227026051A KR20220113543A KR 20220113543 A KR20220113543 A KR 20220113543A KR 1020227026051 A KR1020227026051 A KR 1020227026051A KR 20227026051 A KR20227026051 A KR 20227026051A KR 20220113543 A KR20220113543 A KR 20220113543A
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antigen
cell
cells
tumor
dendritic cells
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Korean (ko)
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알톤 엘. 보인톤
말닉스 엘. 보쉬
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노쓰웨스트 바이오써라퓨틱스, 인크.
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Priority to KR1020237044465A priority Critical patent/KR20240005984A/ko
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KR1020227026051A 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법 Ceased KR20220113543A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237044465A KR20240005984A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74888505P 2005-12-08 2005-12-08
US60/748,885 2005-12-08
KR1020217002605A KR20210013327A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법
PCT/US2006/047083 WO2007067782A2 (en) 2005-12-08 2006-12-08 Compositions and methods for inducing the activation of immature monocytic dendritic cells

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KR1020217002605A Division KR20210013327A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법

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KR1020227026051A Ceased KR20220113543A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법
KR1020157017377A Ceased KR20150082688A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법
KR1020237044465A Ceased KR20240005984A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법
KR1020087016423A Ceased KR20080109717A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한조성물 및 방법
KR1020217002605A Ceased KR20210013327A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법
KR1020187011878A Ceased KR20180049169A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법

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KR1020157017377A Ceased KR20150082688A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법
KR1020237044465A Ceased KR20240005984A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법
KR1020087016423A Ceased KR20080109717A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한조성물 및 방법
KR1020217002605A Ceased KR20210013327A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법
KR1020187011878A Ceased KR20180049169A (ko) 2005-12-08 2006-12-08 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한 조성물 및 방법

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Country Link
US (2) US20080254537A1 (enExample)
EP (3) EP3072958A1 (enExample)
JP (7) JP5954918B2 (enExample)
KR (6) KR20220113543A (enExample)
CN (2) CN103589684A (enExample)
AR (1) AR056851A1 (enExample)
AU (1) AU2006321794A1 (enExample)
BR (1) BRPI0619499A2 (enExample)
CA (1) CA2632263C (enExample)
CR (1) CR10048A (enExample)
IL (2) IL191930A (enExample)
RU (1) RU2008122550A (enExample)
TW (1) TW200800252A (enExample)
WO (1) WO2007067782A2 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070025958A1 (en) 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
AU2002232560A1 (en) 2000-10-27 2002-05-06 Immuno-Rx, Inc Vaccine immunotherapy for immune suppressed patients
EP2276850B9 (en) * 2008-04-14 2013-10-30 IRX Therapeutics, Inc. Irx-2 modified manufacturing process
US8728806B2 (en) * 2008-12-06 2014-05-20 The Board Of Regents, The University Of Texas System Methods and compositions related to Th-1 dendritic cells
WO2010115229A1 (en) * 2009-04-09 2010-10-14 The University Of Melbourne Immunogenic composition and uses thereof
EP2429585B1 (en) 2009-05-15 2018-04-18 IRX Therapeutics, Inc. Vaccine immunotherapy
US9687537B2 (en) * 2009-07-24 2017-06-27 Rhode Island Hospital Dendritic cell vaccines for asparaginyl-β-hydroxylase expressing tumors
US20120183518A1 (en) * 2009-08-24 2012-07-19 Hong Jiang Assay for determining health of cd8+ t cells
EP2498795B1 (en) 2009-10-12 2016-12-07 The United States Of America, As Represented By The Secretary, Department of Health and Human Services Granulysin in immunotherapy
CN103097543A (zh) 2009-12-08 2013-05-08 伊尔克斯治疗有限公司 逆转朗格汉斯细胞免疫抑制的方法
WO2012065156A2 (en) * 2010-11-13 2012-05-18 University Of Florida Research Foundation, Inc. Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells
NL2009102C2 (en) * 2012-07-02 2014-01-06 Dcprime B V Method for dc-loading.
TWI503414B (zh) * 2012-07-05 2015-10-11 Fullhope Biomedical Co Ltd 一種製備專一性t細胞之配方、方法及其配方製備方法
AU2020203845C1 (en) * 2012-09-06 2022-08-11 Orbis Health Solutions, Llc Tumor lysate loaded particles
US20140065173A1 (en) 2012-09-06 2014-03-06 Orbis Health Solutions Llc Tumor lysate loaded particles
EP2931324B1 (en) 2012-12-12 2018-09-19 Orbis Health Solutions LLC Compositions and methods for tissue regeneration
CA2895280C (en) * 2012-12-18 2021-04-06 Immunicum Ab Co-differentiation of monocytes from allogeneic donors
CN112891522A (zh) * 2013-09-05 2021-06-04 奥比思健康解决方案有限责任公司 装载了肿瘤裂解物的微粒
CN103756960A (zh) * 2013-12-04 2014-04-30 深圳市合一康生物科技有限公司 一种高毒性、高增值能力的人d-cik细胞的专用试剂盒
CN103784950A (zh) * 2014-01-22 2014-05-14 北京弘润源生物技术有限公司 乳腺癌特异抗原表位多肽负载的树突状细胞疫苗制备及其试剂盒
US10166195B2 (en) 2014-03-05 2019-01-01 Orbis Health Solutions, Llc Vaccine delivery systems using yeast cell wall particles
CN103800897B (zh) * 2014-03-12 2017-03-22 李金珍 一种肿瘤特异抗原表位多肽负载的树突状细胞疫苗制备方法及其试剂盒
CN106687583B (zh) * 2014-06-23 2020-07-24 Jw可瑞基因株式会社 制备树突细胞的方法和包含所述树突细胞的组合物
WO2016145578A1 (en) * 2015-03-13 2016-09-22 Syz Cell Therapy Co. Methods of cancer treatment using activated t cells
CN108291204A (zh) * 2015-09-15 2018-07-17 西北生物治疗药物公司 涉及用于患有晚期癌症的受试者的经活化树突状细胞组合物和免疫治疗处理的方法
CN105670994A (zh) * 2016-02-28 2016-06-15 深圳爱生再生医学科技有限公司 Dc诱导剂及其应用
CN105647867A (zh) * 2016-02-28 2016-06-08 深圳爱生再生医学科技有限公司 诱导树突状细胞成熟的方法和树突状细胞
US11472856B2 (en) 2016-06-13 2022-10-18 Torque Therapeutics, Inc. Methods and compositions for promoting immune cell function
JP6854290B2 (ja) * 2016-09-01 2021-04-07 株式会社理研免疫再生医学 ナチュラルキラーt(nkt)細胞を刺激する樹状細胞の製造方法、nkt細胞を刺激する樹状細胞、nkt細胞を刺激する樹状細胞とnkt細胞とを含む細胞組成物の製造方法およびnkt細胞を刺激する樹状細胞とnkt細胞とを含む細胞組成物
EP3518942A4 (en) * 2016-09-29 2020-05-27 Hadasit Medical Research Services&Development Ltd. DENDRITIC CELL PREPARATIONS, COMPOSITIONS AND METHODS OF USE
KR20210032924A (ko) 2017-09-05 2021-03-25 토크 테라퓨틱스, 인코포레이티드 치료용 단백질 조성물 및 그의 제조 및 사용 방법
CN109957548B (zh) * 2017-12-26 2022-03-18 上海尚泰生物技术有限公司 一种基因修饰的树突状细胞疫苗
JP6881331B2 (ja) * 2018-01-29 2021-06-02 株式会社三洋物産 遊技機
JP6881333B2 (ja) * 2018-01-29 2021-06-02 株式会社三洋物産 遊技機
JP6881332B2 (ja) * 2018-01-29 2021-06-02 株式会社三洋物産 遊技機
WO2019183924A1 (en) 2018-03-30 2019-10-03 Syz Cell Therapy Co. Improved multiple antigen specific cell therapy methods
JP2021533759A (ja) * 2018-08-10 2021-12-09 ユーティレックス カンパニー リミテッド 癌抗原特異的cd8+t細胞を調製および凍結保存するための方法
CN110106145B (zh) * 2019-06-12 2021-02-12 蓝莲(杭州)生物科技有限公司 一种未成熟树突状细胞培养液及其未成熟树突状细胞的制备方法
US20230173065A1 (en) * 2020-05-15 2023-06-08 Seoul National University R&Db Foundation Composition for enhancing immune response by using activation function of dendritic cells of stromal vascular fractions isolated from adipose tissues
KR102818249B1 (ko) * 2021-11-11 2025-06-10 의료법인 명지의료재단 Kras 특이적 활성화 t 세포 유도용 항원 조성물을 이용한 항원 특이적 t 세포 유도방법
KR102753583B1 (ko) * 2021-11-11 2025-01-10 의료법인 명지의료재단 Kras 특이적 활성화 t 세포 유도용 항원 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69333433T2 (de) 1992-04-01 2004-12-02 The Rockefeller University Verfahren zur in vitro kultivierung dendritischer vorläuferzellen und deren verwendung zur immunogen herstellung
US5788963A (en) 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
US7659119B2 (en) 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
EP1007716A4 (en) * 1997-04-17 2000-06-14 Univ California USE OF LENTIVIRAL VECTORS FOR INTEGRATION INTO DENDRITIC CELLS
US6558951B1 (en) 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
AU2002326463A1 (en) 2001-07-25 2003-02-17 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
ES2766299T3 (es) * 2001-09-06 2020-06-12 Northwest Biotherapeutics Inc Composiciones y procedimientos para la activación linfocitaria de células dendríticas monocíticas y células T para generar una respuesta Th-1
ES2755552T3 (es) 2002-06-19 2020-04-22 Northwest Biotherapeutics Inc Dispositivos de filtración de flujo tangencial y métodos para el enriquecimiento de leucocitos
AT412145B (de) * 2002-09-13 2004-10-25 Forsch Krebskranke Kinder Verfahren zur herstellung eines zellulären immuntherapeutikums auf basis von il-12-freisetzenden dendritischen zellen
AU2004214896A1 (en) * 2003-02-27 2004-09-10 Northwest Biotherapeutics, Inc. Generation of dendritic cells from monocytic dendritic precursor cells with GM-CSF in the absence of additional cytokines

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