KR20220109401A - Parp7 억제제로서의 피리다진온 - Google Patents

Parp7 억제제로서의 피리다진온 Download PDF

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Publication number
KR20220109401A
KR20220109401A KR1020227018075A KR20227018075A KR20220109401A KR 20220109401 A KR20220109401 A KR 20220109401A KR 1020227018075 A KR1020227018075 A KR 1020227018075A KR 20227018075 A KR20227018075 A KR 20227018075A KR 20220109401 A KR20220109401 A KR 20220109401A
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South Korea
Prior art keywords
trifluoromethyl
alkyl
piperidin
oxy
oxo
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Korean (ko)
Inventor
니콜라스 로버트 펄
멜리사 마리 바스빈더
케빈 웨인 쿤츠
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리본 테라퓨틱스 인코포레이티드
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Publication of KR20220109401A publication Critical patent/KR20220109401A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020227018075A 2019-10-30 2020-10-29 Parp7 억제제로서의 피리다진온 Ceased KR20220109401A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962927934P 2019-10-30 2019-10-30
US62/927,934 2019-10-30
PCT/US2020/057831 WO2021087025A1 (en) 2019-10-30 2020-10-29 Pyridazinones as parp7 inhibitors

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Publication Number Publication Date
KR20220109401A true KR20220109401A (ko) 2022-08-04

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KR1020227018075A Ceased KR20220109401A (ko) 2019-10-30 2020-10-29 Parp7 억제제로서의 피리다진온

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US (2) US11691969B2 (enExample)
EP (1) EP4051384A1 (enExample)
JP (1) JP7641957B2 (enExample)
KR (1) KR20220109401A (enExample)
CN (1) CN114761086B (enExample)
AR (1) AR120338A1 (enExample)
AU (1) AU2020375821B2 (enExample)
CA (1) CA3159188A1 (enExample)
IL (1) IL292432B1 (enExample)
MX (1) MX2022005216A (enExample)
PH (1) PH12022551013A1 (enExample)
TW (1) TWI902715B (enExample)
WO (1) WO2021087025A1 (enExample)

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WO2020223229A1 (en) 2019-04-29 2020-11-05 Ribon Therapeutics, Inc. Solid forms of a parp7 inhibitor
TWI902715B (zh) 2019-10-30 2025-11-01 美商律幫治療股份有限公司 作為ｐａｒｐ７抑制劑的嗒酮
CN116157396B (zh) * 2020-11-27 2025-07-18 康百达（四川）生物医药科技有限公司 哒嗪酮衍生物及其在医药上的应用
US20240166664A1 (en) * 2021-02-03 2024-05-23 Shanghai Apeiron Therapeutics Company Limited Triheterocyclic compound, preparation method therefor, and application thereof
EP4291560A4 (en) * 2021-02-09 2025-01-15 Jacobio Pharmaceuticals Co., Ltd. TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS
WO2022188889A1 (zh) * 2021-03-12 2022-09-15 杭州英创医药科技有限公司 作为parp7抑制剂的化合物
CN117279917A (zh) * 2021-05-21 2023-12-22 成都百裕制药股份有限公司 哌嗪衍生物及其在医药上的应用
WO2022247839A1 (zh) * 2021-05-25 2022-12-01 山东轩竹医药科技有限公司 Parp7抑制剂
CN115477640A (zh) * 2021-05-31 2022-12-16 由理生物医药（上海）有限公司 作为parp7抑制剂的哒嗪酮类化合物
WO2023001247A1 (zh) * 2021-07-21 2023-01-26 南京明德新药研发有限公司 哒嗪酮类化合物
WO2023001296A1 (zh) * 2021-07-23 2023-01-26 武汉人福创新药物研发中心有限公司 作为parp7抑制剂的哒嗪酮类化合物
WO2023011629A1 (zh) * 2021-08-06 2023-02-09 成都百裕制药股份有限公司 吡咯烷酮衍生物及其在医药上的应用
WO2023020479A1 (zh) * 2021-08-16 2023-02-23 重庆华森制药股份有限公司 Parp7抑制剂及其应用
EP4423078A1 (en) 2021-10-28 2024-09-04 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
CN115745971B (zh) * 2021-12-20 2024-07-30 北京华森英诺生物科技有限公司 Parp7抑制剂及其应用
CN116444497B (zh) * 2022-01-14 2025-06-24 如东凌达生物医药科技有限公司 一类哒嗪酮类化合物、制备及其应用
CA3248911A1 (en) 2022-01-28 2023-08-03 Gilead Sciences, Inc. POLY(ADENOSINE DIPHOSPHATE-RIBOSE) POLYMERASE 7 INHIBITORS
WO2023185073A1 (zh) * 2022-04-01 2023-10-05 诺沃斯达药业(上海)有限公司 Parp7抑制剂及其用途
CN117586263B (zh) * 2022-08-09 2026-04-10 康百达（四川）生物医药科技有限公司 哌嗪衍生物及其在医药上的应用
EP4570249A4 (en) * 2022-08-09 2026-07-22 Kangbaida Sichuan Biotechnology Co Ltd USE OF A PIPERAZINE COMPOUND IN COMBINATION WITH RADIOTHERAPY FOR THE TREATMENT OF A TUMOR
TW202416984A (zh) * 2022-08-17 2024-05-01 大陸商北京加科思新藥研發有限公司 化合物i或其鹽的固體形式
CN117164524B (zh) * 2022-09-06 2026-02-03 杭州师范大学 具有parp7/hdac双靶点抑制活性的哒嗪酮衍生物及其制备方法和应用
WO2024149231A1 (en) * 2023-01-10 2024-07-18 Angel Pharmaceutical Co., Ltd. Parp7 inhibitors and uses thereof
CN118388414A (zh) * 2023-01-17 2024-07-26 中国药科大学 哒嗪酮类化合物及其制备方法、药物组合物和应用
CN121752568A (zh) * 2023-08-29 2026-03-27 康百达（四川）生物医药科技有限公司 一种哌嗪衍生物的制备工艺及其中间体

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US11293927B2 (en) 2018-04-30 2022-04-05 Ribon Therapeutics, Inc. Screening methods for PARP modulators
WO2020223229A1 (en) 2019-04-29 2020-11-05 Ribon Therapeutics, Inc. Solid forms of a parp7 inhibitor
WO2021087018A1 (en) 2019-10-30 2021-05-06 Ribon Therapeutics, Inc. Pyridazinones as parp7 inhibitors
TWI902715B (zh) 2019-10-30 2025-11-01 美商律幫治療股份有限公司 作為ｐａｒｐ７抑制劑的嗒酮
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CN114761086B (zh) 2025-07-22
EP4051384A1 (en) 2022-09-07
CN114761086A (zh) 2022-07-15
PH12022551013A1 (en) 2023-03-06
US12617782B2 (en) 2026-05-05
TWI902715B (zh) 2025-11-01
TW202128653A (zh) 2021-08-01
JP7641957B2 (ja) 2025-03-07
WO2021087025A1 (en) 2021-05-06
US11691969B2 (en) 2023-07-04
MX2022005216A (es) 2022-06-02
CA3159188A1 (en) 2021-05-06
US20240034728A1 (en) 2024-02-01
IL292432A (en) 2022-06-01
JP2023501253A (ja) 2023-01-18
IL292432B1 (en) 2026-05-01
AR120338A1 (es) 2022-02-09
AU2020375821A1 (en) 2022-06-02
AU2020375821B2 (en) 2026-03-19
US20210130342A1 (en) 2021-05-06

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