KR20220107330A - Dp 길항제 - Google Patents

Dp 길항제 Download PDF

Info

Publication number
KR20220107330A
KR20220107330A KR1020227025551A KR20227025551A KR20220107330A KR 20220107330 A KR20220107330 A KR 20220107330A KR 1020227025551 A KR1020227025551 A KR 1020227025551A KR 20227025551 A KR20227025551 A KR 20227025551A KR 20220107330 A KR20220107330 A KR 20220107330A
Authority
KR
South Korea
Prior art keywords
phenyl
chloro
halogen atom
atom
acetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020227025551A
Other languages
English (en)
Korean (ko)
Inventor
마사키 아사다
게이스케 하나다
사토노리 히구치
아츠시 나가나와
야스히로 다케다
Original Assignee
오노 야꾸힝 고교 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오노 야꾸힝 고교 가부시키가이샤 filed Critical 오노 야꾸힝 고교 가부시키가이샤
Publication of KR20220107330A publication Critical patent/KR20220107330A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Auxiliary Devices For Music (AREA)
KR1020227025551A 2018-09-20 2019-09-19 Dp 길항제 Withdrawn KR20220107330A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2018175758 2018-09-20
JPJP-P-2018-175758 2018-09-20
PCT/JP2019/036725 WO2020059790A1 (ja) 2018-09-20 2019-09-19 Ｄｐアンタゴニスト
KR1020217008017A KR102425709B1 (ko) 2018-09-20 2019-09-19 Dp 길항제

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020217008017A Division KR102425709B1 (ko) 2018-09-20 2019-09-19 Dp 길항제

Publications (1)

Publication Number Publication Date
KR20220107330A true KR20220107330A (ko) 2022-08-02

Family

ID=69888481

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020227025551A Withdrawn KR20220107330A (ko) 2018-09-20 2019-09-19 Dp 길항제
KR1020217008017A Active KR102425709B1 (ko) 2018-09-20 2019-09-19 Dp 길항제

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020217008017A Active KR102425709B1 (ko) 2018-09-20 2019-09-19 Dp 길항제

Country Status (17)

Country Link
US (3) US11319296B2 (enExample)
EP (1) EP3854781B1 (enExample)
JP (2) JP7021709B2 (enExample)
KR (2) KR20220107330A (enExample)
CN (1) CN112739680A (enExample)
AU (1) AU2019341082A1 (enExample)
BR (1) BR112021005260A2 (enExample)
CA (1) CA3113210A1 (enExample)
ES (1) ES2982217T3 (enExample)
IL (2) IL310383A (enExample)
MX (1) MX2021003131A (enExample)
NZ (1) NZ774113A (enExample)
PH (1) PH12021550549A1 (enExample)
SG (1) SG11202102566YA (enExample)
TW (2) TWI784199B (enExample)
WO (1) WO2020059790A1 (enExample)
ZA (1) ZA202101887B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11319296B2 (en) * 2018-09-20 2022-05-03 Ono Pharmaceutical Co., Ltd. DP antagonist
TW202146394A (zh) * 2020-03-19 2021-12-16 日商小野藥品工業股份有限公司 苯乙酸化合物之結晶
JP2024016311A (ja) * 2020-12-24 2024-02-07 小野薬品工業株式会社 Ｅｐ２アンタゴニスト

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003078409A1 (en) 2002-03-19 2003-09-25 Ono Pharmaceutical Co., Ltd. Carboxyoic acid compounds and drugs containing the compounds as the active ingredient
WO2005028455A1 (ja) 2003-09-17 2005-03-31 Ono Pharmaceutical Co., Ltd. カルボン酸化合物およびそれらを有効成分として含有する医薬組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994479A (en) * 1985-04-03 1991-02-19 Yamanouchi Pharmaceutical Co., Ltd. Phenylene derivatives and anti-allergic use thereof
JPS63159342A (ja) * 1985-04-03 1988-07-02 Yamanouchi Pharmaceut Co Ltd 新規カルボン酸化合物
EP1723132A1 (en) * 2004-02-12 2006-11-22 Asterand Uk Limited Ep2 receptor agonists
US7803786B2 (en) 2004-06-17 2010-09-28 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions and related methods of use
TWI410410B (zh) * 2007-08-10 2013-10-01 Ono Pharmaceutical Co Phenylacetic acid compounds
CA2849350A1 (en) 2011-09-26 2013-04-04 Grunenthal Gmbh Amine substituted methanesulfonamide derivatives as vanilloid receptor ligands
JP2020502189A (ja) 2016-12-20 2020-01-23 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ インドールアミン２，３−ジオキシゲナーゼのモジュレーター
JP6533249B2 (ja) 2017-04-21 2019-06-19 山佐株式会社 遊技機用基板ケースの取り付け構造及び遊技機
CN110785408A (zh) 2017-06-28 2020-02-11 葛兰素史克知识产权开发有限公司 吲哚胺2,3-双加氧酶的调节剂
US11319296B2 (en) 2018-09-20 2022-05-03 Ono Pharmaceutical Co., Ltd. DP antagonist

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003078409A1 (en) 2002-03-19 2003-09-25 Ono Pharmaceutical Co., Ltd. Carboxyoic acid compounds and drugs containing the compounds as the active ingredient
WO2005028455A1 (ja) 2003-09-17 2005-03-31 Ono Pharmaceutical Co., Ltd. カルボン酸化合物およびそれらを有効成分として含有する医薬組成物

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
[비특허문헌 1] 더 뉴 잉글랜드 저널 오브 메디슨(The NEW ENGLAND JOURNAL of MEDICINENE), Vol. 303, 1400-1404, 1980
[비특허문헌 10] 더 저널 오브 알레르기 앤드 클리니컬 이뮤놀로지(The Journal of Allergy and Clinical Immunology), Vol. 87, 540-548, 1991
[비특허문헌 11] 더 저널 오브 알레르기 앤드 클리니컬 이뮤놀로지(The Journal of Allergy and Clinical Immunology), Vol. 78, 458-461, 1986
[비특허문헌 12] 프로시딩스 오브 더 내셔널 아카데미 오브 사이엔시즈 오브 더 유나이티드 스테이츠 오브 아메리카(Proceedings of the National Academy of Sciences of the United States of America), Vol. 98, 11674-11679, 2001
[비특허문헌 2] 아메리칸 리뷰 오브 레스퍼레토리 디지즈(American Review of Respiratory Disease), Vol. 128, 597-602, 1983
[비특허문헌 3] 더 저널 오브 알레르기 앤드 클리니컬 이뮤놀로지(The Journal of Allergy and Clinical Immunology), Vol. 88, 33-42, 1991
[비특허문헌 4] 아카이브스 오브 오토라린골로지-헤드 앤드 넥 서저리(Archives of Otolaryngology-Head and Neck Surgery), Vol. 113, 179-83, 1987
[비특허문헌 5] 더 저널 오브 알레르기 앤드 클리니컬 이뮤놀로지(The Journal of Allergy and Clinical Immunology), Vol. 82, 869-77, 1988
[비특허문헌 6] 더 저널 오브 이뮤놀로지(The Journal of Immunology), Vol. 146, 671-676, 1991
[비특허문헌 7] 더 저널 오브 알레르기 앤드 클리니컬 이뮤놀로지(The Journal of Allergy and Clinical Immunology), Vol. 83, 905-912, 1989
[비특허문헌 8] 더 뉴 잉글랜드 저널 오브 메디슨(The NEW ENGLAND JOURNAL of MEDICINENE), Vol. 315, 800-804, 1986
[비특허문헌 9] 아메리칸 리뷰 오브 레스퍼레토리 디지즈(American Review of Respiratory Disease), Vol. 142, 126-132, 1990

Also Published As

Publication number Publication date
KR102425709B1 (ko) 2022-07-28
US20250042870A1 (en) 2025-02-06
IL281433A (en) 2021-04-29
JPWO2020059790A1 (ja) 2021-09-02
EP3854781B1 (en) 2024-05-22
WO2020059790A1 (ja) 2020-03-26
TWI784199B (zh) 2022-11-21
AU2019341082A1 (en) 2021-04-15
EP3854781A1 (en) 2021-07-28
JP2022058610A (ja) 2022-04-12
TWI822457B (zh) 2023-11-11
US20220204468A1 (en) 2022-06-30
JP7338711B2 (ja) 2023-09-05
US11319296B2 (en) 2022-05-03
MX2021003131A (es) 2021-05-14
ZA202101887B (en) 2022-10-26
JP7021709B2 (ja) 2022-02-17
TW202308986A (zh) 2023-03-01
CA3113210A1 (en) 2020-03-26
NZ774113A (en) 2024-09-27
US20220033371A1 (en) 2022-02-03
IL310383A (en) 2024-03-01
EP3854781A4 (en) 2022-02-23
TW202023535A (zh) 2020-07-01
PH12021550549A1 (en) 2022-02-14
KR20210065944A (ko) 2021-06-04
ES2982217T3 (es) 2024-10-15
CN112739680A (zh) 2021-04-30
SG11202102566YA (en) 2021-04-29
BR112021005260A2 (pt) 2021-06-15

Similar Documents

Publication Publication Date Title
JP7338711B2 (ja) Ｄｐアンタゴニスト
AU2015336458B2 (en) KCNQ2-5 channel activator
JP7750341B2 (ja) Ａｂｈｄ６アンタゴニスト
WO2020262603A1 (ja) Ｅｐ２アンタゴニスト
JP6197971B1 (ja) Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤
RU2803243C2 (ru) Антагонист dp
JP7047954B2 (ja) フェニル酢酸化合物を含有する医薬組成物
HK40051095A (en) Dp antagonist
AU2023352529A1 (en) Abhd6 antagonist
JP2024052624A (ja) Ａｂｈｄ６アンタゴニストを含有する医薬組成物

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A16-div-PA0104

St.27 status event code: A-0-1-A10-A18-div-PA0104

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

PC1202 Submission of document of withdrawal before decision of registration

St.27 status event code: N-1-6-B10-B11-nap-PC1202